551 research outputs found
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
No full textChronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD
Spectrum to distance mapping via nonlinear Airy pulses
No full textWe theoretically and experimentally study the phenomena related to self-phase modulation of Airy pulses in fibers. During nonlinear evolution, most spectral components of the Airy pulses concentrate into one or two peaks for normal and anomalous dispersion, respectively. The resulting peaks self-shift along the propagation, effectively mapping the longitudinal coordinate into the frequency domain. The frequency shift can be precisely controlled by simply acting on the spectral cubic phase structure without the need to alter the fiber length. (C) 2013 Optical Society of Americ
Specificity and definiteness in sentence and discourse structure
No full textIn this paper, I argue that this informally given list of characteristics covers only a certain subclass of specific indefinites. […] In particular, I dispute the definition of specific indefinites as "the speaker has the referent in mind" as rather confusing if one is working with a semantic theory. Furthermore, I discuss "relative specificity", it. cases in which the specific indefinite does not exhibit wide, but intermediate or narrow scope behavior. Based on such data, I argue that specificity expresses a referential dependency between introduced discourse items. Informally speaking, the specificity of the indefinite expression something [...] expresses that the reference of the expression depends on the reference of another expression, here, on the expression a monk, not the speaker
DIFFERENTIATION OF SECONDARY XYLEM AFTER GIRDLING
No full textPlant SciencesForestrySCI(E)13ARTICLE4375-383
Factorization of the two loop four-particle amplitude in superstring theory revisited
No full textWe study in detail the factorization of the newly obtained two-loop four-particle amplitude in superstring theory. In particular some missing factors from the scalar correlators are obtained correctly, in comparing with a previous study of the factorization in two-loop superstring theory. Some details for the calculation of the factorization of the kinematic factor are also presented.Physics, Particles & FieldsSCI(E)0ARTICLE6nul
Segmentação binível de imagens usando entropia difusa bidimensional e distribuição da orientação de gradiente dos pixels /
No full textDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico
Red organic light-emitting diode with non-doping DCM as emitter
No full textA new kind of non-doping red OLED was fabricated, using partially conjugated PPV as hole-transport material and non-doping DCM as emitter. The new OLED shows good performance of pure red luminescence. (c) 2005 Optical Society of America.OpticsCPCI-S(ISTP)
Tunable visual color filter using microfluidic grating
No full textAuthor name used in this publication: X. M. Zhang2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedVoR allowe
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