125 research outputs found
Detection of AR-V7 mRNA in whole blood may not predict the effectiveness of novel endocrine drugs for castration-resistant prostate cancer
No full textTakumi Takeuchi, Yumiko Okuno, Mami Hattori-Kato, Masayoshi Zaitsu, Koji MikamiDepartment of Urology, Kanto Rosai Hospital, Kawasaki, JapanAbstract: A splice variant of androgen receptor (AR), AR-V7, lacks in androgen-binding portion and leads to aggressive cancer characteristics. Reverse transcription-polymerase chain reactions (PCRs) and subsequent nested PCRs for the amplification of AR-V7 and prostate-specific antigen (PSA) transcripts were done for whole blood of patients with prostate cancer and male controls. With primary reverse transcription PCRs, AR-V7 and PSA were detected in 4.5% and 4.7% of prostate cancer, respectively. With nested PCRs, AR-V7 messenger RNA (mRNA) was positive in 43.8% of castration-sensitive prostate cancer and 48.1% of castration-resistant prostate cancer (CRPC), while PSA mRNA was positive in 6.3% of castration-sensitive prostate cancer and 18.5% of CRPC. Whole-blood samples of controls showed AR-V7 mRNA expression by nested PCR. Based on multivariate analysis, expression of AR-V7 mRNA in whole blood was not significantly correlated with clinical parameters and PSA mRNA in blood, while univariate analysis showed a correlation between AR-V7 mRNA and metastasis at initial diagnosis. Detection of AR-V7 mRNA did not predict the reduction of serum PSA in patients with CRPC following abiraterone and enzalutamide administration. In conclusion, AR-V7 mRNA expression in normal hematopoietic cells may have annihilated the manifestation of aggressiveness of prostate cancer and the prediction of the effectiveness of abiraterone and enzalutamide by the assessment of AR-V7 mRNA in blood.Keywords: AR-V7, prostate cancer, castration-resistan
脂肪滴はヒト肝細胞株におけるPorphyromonas gingivalisのオートファジー・リソソームシステムを介した排除機構に影響する
No full textRecent studies have shown that infection with Porphyromonas gingivalis, a major periodontal pathogen, hastens the progression of non-alcoholic fatty liver disease (NAFLD). However, the intracellular fate of P. gingivalis in hepatocytes remains unknown. Here, using oleic-acid-induced HepG2 cells as an in vitro model for NAFLD, we found that lipid droplets increased the existence of P. gingivalis in the cells at an early phase of infection. Confocal microscopic analysis revealed that lipid droplets affected the formation of autolysosomes in infected cells. Thus, lipid droplets affect the elimination of P. gingivalis in HepG2 cells by altering the autophagy-lysosome system.長崎大学学位論文 学位記番号:博(医歯薬)甲第916号 学位授与年月日:平成29年3月21日Author: Yumi Zaitsu, Mayumi Iwatake, Keiko Sato, Takayuki TsukubaCitation: Microbes and Infection, 18(9), pp.565-571;201
Generation of a 12-fs ultraviolet optical pulse using two types of coherent molecular rotations
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東インドと隣接諸王国における珍奇なものに関する略説」 ー ライプツィッヒの外科医兼商人カスパル・シャムベルゲルの生涯と業績に関する新発見 ー
No full textEinleitung / Abriss eines abenteuerlichen Lebens / Zurück aus Ostindien – Schamberger in Leipzig / Zum Druck der Schambergerschen Erläuterung/ Struktur und Besonderheiten der drei Schildereyen / Mitbringsel aus der Fremde / Frühe Ostindien-Fahrer und ihre Bildmaterialien / Caspar Schmalkalden / Zacharias Wagener / Heinrich Muche / Johann Wilhelm Vogel / Elias Hesse / Albrecht Herport / George Meister / Andreas Cleyer / Engelbert Kaempfer / Zum Inhalt der Schambergerschen »Erläuterung« / Handel und Wandel der Niederländer in Ostindien / Früchte, Wurzeln, Nüsse / Tiere / Münzen / Ethnische Abbildungen / Sprache und Schrift / Rückblick / Text: Dreier in Untertänigkeit offerierten Schildereien kurze Erläuterung / Quellen und Literatur / Handschriftliche Quellen / Gedruckte Quellen (16.-18. Jh.) / Sekundärliteratur / Allgemeine Nachschlagewerke / RegisterThis book presents a newly discovered text of which only one copy has survived in the Dresden State Art Collections (Staatliche Kunstsammlungen Dresden, Münzkabinett). It was dedicated to the Duke of Saxony Johann Georg III. and published in 1686 as a private print under the title \u22Short explanation of the most prominent rarities in East India and the neighbouring kingdoms\u22. The author Caspar Schamberger (1623-1706) had worked in Asia for twelve years as a surgeon on VOC ships and in Dutch trading posts. He is known as the \u22father\u22 of the first fully-fledged Western-style medical school in Japan. His text describes fruits, plants, animals, ethnic groups, coins etc. from Persia to Japan including the Khoikhoi (Khoisan) in Southern Africa. This is one of the earliest Western accounts of these matters based on observations made during the late 1640s and 1650s. The extensive commentary (126 pages) gives an outline of Schamberger\u27s life presenting numerous new information on his activities after his return to Leipzig in 1658. Schamberger\u27s descriptions are analysed in detail within the context of similar accounts of nine contemporary German travellers: Caspar Schmalkalden, Zacharias Wagener, Heinrich Muche, Johann Wilhelm Vogel, Elias Hesse, Albrecht Herport, George Meister, Andreas Cleyer, Engelbert Kaempfer. Forty-six illustrations selected from Western and Japanese sources proviede the iconographic background
In situ third-order interferometric autocorrelation of a femtosecond deep-ultraviolet pulse
No full textEngelbert Kaempfers Beschäftigung mit der japanischen Sprache
No full text「西洋人からみた日本語」について様々な研究が行われてきているが、ケンペルの重要性は筆者の研究に至るまでまったく認識されていなかった。解読が不可能とされていた大英図書館蔵ケンペルのメモなどの日本関係の資料集ＳＬ３０６２に見られる彼の日本語観及び日本語研究について詳細に論じている。* ケンペルの日本語力、* ケンペルから見た日本語の一般的特徴および位置づけ、* ケンペルの日本語の発音についての観察およびそのローマ字表記、* ケンペルの日本語の単語集、* ケンペルから見た日本語の文法上の特徴、* 日本語の談話の例文及び日本語運用についての記述、* 日本語の文字について、* 文書のサンプル及びローマ字表記、* ケンペルに協力した人々、* ケンペルが入手した日本語関係の書物、* 日本語研究史におけるケンペルの位置づけFrom the publishers leaflet: "Engelbert Kaempfer was the most celebrated German explorer of the baroque period. He stayed in Japan from 1690 to 1692. His reports in Amoenitates Exoticae and in the History of Japan have shaped European views of Japan fo centuries. One can directly trace the stereotypification of the consensus society and the image of the self-contained country back to Kaempfer. This volume includes the most important essays and contributions presented at two conferences held in 1990 on the occasion of the 300th anniversary of Kaempfer's landing in Japan - a symposium held in Tokyo by the German Institute of Japanese Studies and a symposium organized bz the Engelbert-Kaempfer Society Lemgo. It considers biographical, historical, linguistic, botanic, medical and geographical aspects of Kaempfer's work. Along with articles on Kampfer's research on the Near East and India, the publication gives prominence to work by Y. Brown, W. Michel, W. Muntschik, Y. Nagasumi, P. van den Velde and others who offer new insights into Kaempfer's work on Japan and connected materials." --- Using several unpublished sources from the Kaempfer collection in the British Library this paper deals with Kaempfer's research on the Japanese language: Kaempfer's method of transliteration, his glossary and phrase samples, his notes on the writing system as well as his view on the origin of the Japanese language and its relation to the Chinese language etc. This is the first study ever on that matter.Wolfgang Michel: Engelbert Kaempfers Beschäftigung mit der japanischen Sprache. In: Detlef Haberland (ed.): Engelbert Kaempfer. Werk und Wirkung. und Boethius-Verlag, Stuttgart 1993. pp. 194-221
Engelbert Kaempfer\u27s Study of the Japanese Language
No full text* ケンペルの日本語力、* ケンペルから見た日本語の一般的特徴および位置づけ、* ケンペルの日本語の発音についての観察およびそのローマ字表記、* ケンペルの日本語の単語集、* ケンペルから見た日本語の文法上の特徴、* 日本語の談話の例文及び日本語運用についての記述、* 日本語の文字について、* 文書のサンプル及びローマ字表記、* ケンペルに協力した人々、* ケンペルが入手した日本語関係の書物、* 日本語研究史におけるケンペルの位置づけFrom the publishers leaflet: \u22Engelbert Kaempfer was the most celebrated German explorer of the baroque period. He stayed in Japan from 1690 to 1692. His reports in Amoenitates Exoticae and in the History of Japan have shaped European views of Japan fo centuries. One can directly trace the stereotypification of the consensus society and the image of the self-contained country back to Kaempfer. This volume includes the most important essays and contributions presented at two conferences held in 1990 on the occasion of the 300th anniversary of Kaempfer\u27s landing in Japan - a symposium held in Tokyo by the German Institute of Japanese Studies and a symposium organized bz the Engelbert-Kaempfer Society Lemgo. It considers biographical, historical, linguistic, botanic, medical and geographical aspects of Kaempfer\u27s work. Along with articles on Kampfer\u27s research on the Near East and India, the publication gives prominence to work by Y. Brown, W. Michel, W. Muntschik, Y. Nagasumi, P. van den Velde and others who offer new insights into Kaempfer\u27s work on Japan and connected materials.\u22 --- Using several unpublished sources from the Kaempfer collection in the British Library this paper deals with Kaempfer\u27s research on the Japanese language: Kaempfer\u27s method of transliteration, his glossary and phrase samples, his notes on the writing system as well as his view on the origin of the Japanese language and its relation to the Chinese language etc. This is the first study ever on that matter.Wolfgang Michel: Engelbert Kaempfers Beschäftigung mit der japanischen Sprache. In: Detlef Haberland (ed.): Engelbert Kaempfer. Werk und Wirkung. und Boethius-Verlag, Stuttgart 1993. pp. 194-221.「西洋人からみた日本語」について様々な研究が行われてきているが、ケンペルの重要性は筆者の研究に至るまでまったく認識されていなかった。解読が不可能とされていた大英図書館蔵ケンペルのメモなどの日本関係の資料集ＳＬ３０６２に見られる彼の日本語観及び日本語研究について詳細に論じている
Relationship between self-assessment and clinical evaluation of dental plaque and gingival condition in Japanese adolescents
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