656 research outputs found
DS1_JVDI_10.1177_1040638719841096 – Supplemental material for Multiplex detection of six swine viruses on an integrated centrifugal disk using loop-mediated isothermal amplification
No full textSupplemental material, DS1_JVDI_10.1177_1040638719841096 for Multiplex detection of six swine viruses on an integrated centrifugal disk using loop-mediated isothermal amplification by Xiangfen Yuan, Jizhou Lv, Xiangmei Lin, Chunyan Zhang, Junhua Deng, Caixia Wang, Xiaopan Fan, Yonggui Wang, Hui Xu and Shaoqiang Wu in Journal of Veterinary Diagnostic Investigation</p
Interaction between ephrin/Eph and BDNF in modulating hippocampal synaptic transmission and synapse formation
No full textThe hippocampus is a brain structure known to be critical for learning and memory consolidation. Abnormal development or damage to this structure is known to play a role in developmental or degenerative neurological disorders such as autism and Alzheimer's disease. In this thesis, I argue that an interaction between ephrin/Eph and BDNF signaling pathways is critical for the development of the selective connection of CA3 neurons to CA1 neurons in hippocampus. This claim was evaluated on the basis of electrophysiology evidence about the ephrin/Eph -- BDNF interaction in synaptic activity, and the effect of the interrupting Eph and BDNF signaling on the hippocampal projection specificity onto CA1 neurons by functional synapse identification via the combination of electrophysiology and immunocytochemistry.
First, I confirmed that the primary hippocampal neuronal culture can be a model for studying the specificity of synaptic connection within the hippocampal circuitry. Functional synapses were characterized by recording from pairs of cells which we subsequently identified with immunocytochemical labeling. Most connections were unidirectional, and I found that when one of the cells was a CA1 neuron (identified by labeling with the CA1 marker anti-SCIP) it was predominantly the postsynaptic member of the pair, a result consistent with in vivo connectivity. Second, ephrin-A/EphA signaling was shown to produce a transient increase in synaptic transmission and be able to inhibit the effect of subsequent BDNF application on synaptic activity. These electrophysiological experiments were suggestive of possible interaction between ephrin-A/EphA and BDNF in modulation synapse formation. Third, interruption of the endogenous EphA signaling by the kinase dominant negative EphA constructs significantly changed the natural synaptic connection selectivity in the hippocampal circuitry and dramatically increased the bi-directional connections in the culture as a consequence.
The empirical results presented in this thesis provide a valuable mechanism for hippocampal trisynaptic circuitry development and function through balancing opposite influences of various modulating factors at specific developmental phases.Ph.D.Includes bibliographical references (p. 94-112)
New Advances at the Intersection of Brain-Inspired Learning and Deep Learning in Autonomous Vehicles and Robotics
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Analysis of the Characteristics of Narrative Types in Contemporary Chinese Political Discourses: Taking Xi Jinping’s Discourses on the History of the CPC as an Example
No full textBased on the different contents, topics, and characteristics of the history of the Communist Party of China (CPC), Xi Jinping’s important discourses on the history of the CPC integrate three narrative types: philosophical narrative, historical narrative, and literary narrative. The integration of the three typical narrative types enables the important discourses on the history of the CPC to contain profound philosophical speculation, heavy historical connotation, and aesthetic and literary conception. The value and significance of exploring the narrative types of Xi Jinping’s important discourses on the history of the CPC lie in continuously strengthening the study of Marxist classic works and promoting the Sinicization of Marxism, improving the Party history narrators’ theoretical attainment and excellent traditional Chinese cultural literacy, actively participating in various forms of social practice activities, accumulating socialized discourse materials through close contact with people from different social classes, and enriching the “corpus” of discourses of the history of the CPC, thus making the narratives deeper and more concrete
The Impact of Positive Psychology-based Classroom on English Speaking Teaching and Learning of EFL College Students
No full textPositive psychology (PP) insists that a positive environment can promote intrinsic motivation and self-construction. To explore and verify whether a positive classroom environment in English speaking teaching can enhance EFL college students’ classroom engagement and boost their speaking proficiency and examine the practice of applying a PP-based positive classroom environment to spoken language teaching of EFL college students, this research takes two English classes in Z University as the research objects, employing PP as the theoretical framework to create a positive classroom environment, adopting a combination of quantitative and qualitative research methods, and conducts a comparative experiment for one semester. The research finds that speaking teaching of EFL college students based on a positive classroom environment can enhance EFL students’ classroom engagement and boost their speaking proficiency. To go a step further, this research, based on the teaching practice, summarizes the methods and strategies of creating a positive classroom environment and provides a teaching sample for reference, thus offering theoretical support and practical recommendations for speaking teaching and learning of EFL college students
Research on Design and Application of Brand Vision Inspection and Sorting System Based on Image Processing
No full textRecurrent Neural Network Language Model with Part-of-speech for Mandarin Speech Recognition
No full textRecurrent neural network language models (RNNLMs) have been successfully applied in a variety of language processing applications ranging from speech recognition to machine translation. They can fight the curse of dimensionality by learning a distributed representation (word vector). The components of these vectors measure the co-occurrence of the word with context features over a corpus. However, RNNLMs ignore the fact that the meaning of word can vary substantially in different contexts (e.g., for polysemous words). In this paper, we investigate part-of-speech information to address this issue to some extent on the basis of information about the meaning of a word they could provide. Experimental results on Mandarin speech recognition task show that a significant character error reduction of 1.18% absolute (7.72% relative) was obtained when using recurrent neural network language model with part-of-speech.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349765600118&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Computer Science, Artificial IntelligenceCPCI-S(ISTP)
The Effect of Part-of-speech on Mandarin Speech Recognition
No full textThis paper concentrates on the effect of part-of-speech on Mandarin speech recognition by incorporating it into language model and pronunciation dictionary. This work is motivated by the two benefits of part-of-speech, one is to reduce the lexical ambiguity in language model to some extent and the other is to provide some information about the pronunciation of heteronyms. The experiments conducted on two corpora, tagged manually or automatically, show that a 3% relative character error rate (CER) reduction is achieved. Moreover, we find that performance improvement is mainly due to the relationship between part-of-speech and pronunciation of heteronyms.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000331094400069&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Engineering, Electrical & ElectronicCPCI-S(ISTP)
Analysis of the Characteristics of Narrative Types in Contemporary Chinese Political Discourses: Taking XI Jinping's Discourses on the History of the CPC as an Example
No full textBased on the different contents, topics, and characteristics of the history of the Communist Party of China (CPC), Xi Jinping's important discourses on the history of the CPC integrate three narrative types: philosophical narrative, historical narrative, and literary narrative. The integration of the three typical narrative types enables the important discourses on the history of the CPC to contain profound philosophical speculation, heavy historical connotation, and aesthetic and literary conception. The value and significance of exploring the narrative types of Xi Jinping's important discourses on the history of the CPC lie in continuously strengthening the study of Marxist classic works and promoting the Sinicization of Marxism, improving the Party history narrators' theoretical attainment and excellent traditional Chinese cultural literacy, actively participating in various forms of social practice activities, accumulating socialized discourse materials through close contact with people from different social classes, and enriching the “corpus” of discourses of the history of the CPC, thus making the narratives deeper and more concrete
The Spatial Position of Xi Jinping’s Thought on Ecological Rule of Law: From the Perspective of Marxist Space Theory
No full textSpace theory is an important part of Marxism. It is the source of the continuation, inheritance, and development of the space theory of New Marxism in the second half of the 20th century. The Marxist space theory adheres to the people-centered space position, which has had an undeniable impact on the post-Marxist party’s ruling philosophy, ruling guidance, and ruling strategy. There has formed a profound, extensive, and practical ecological rule of law, namely Xi Jinping’s thoughts on the ecological rule of law, in the great practice of leading the construction of ecological civilization in China in the new era since the 18th National Congress of the Communist Party of China. The idea of Xi Jinping’s thought of the ecological rule of law adheres to the people-centered space position, attaches great importance to building high-quality ecological space for the people, practically guarantees the equal enjoyment of high-quality ecological space by the people according to law, and advocates the construction of high-quality ecological space for all mankind
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