10,523 research outputs found
Enhancing the Fed’s transparency didn’t hurt its deliberations
No full textFor more than two decades, transcripts of the US Federal Reserve’s Open Market Committee meetings have been made available to the public. But has the move to greater transparency about monetary policymaking hurt committee deliberations? In new research which examines committee meeting transcripts from 1978 to 2007, Joseph Gardner and John T. Woolley find that leadership – not transparency – had the greatest effect on how members deliberated during meetings
In Fed meetings, decision making is free – but not equal.
No full textWith its ability to influence interest rates globally, the Federal Open Market Committee (FOMC) of the US Federal Reserve is arguably one of the most important decision making bodies on the planet. But how does it come to its decisions? In new research which analyses transcripts of FOMC deliberations over nearly 30 years, Joseph Gardner and John T. Woolley find that women speak less than men for nearly their entire tenure on the FOMC. While women are free to speak, they write, they do not participate equally in FOMC deliberations, and this could be influencing policy choices
Letter from John H. Page to Carl Hayden
No full textLetter from John H. Page to Carl T. Hayden regarding his company's rights to build a railway if they choose to
John T. Hamilton, <em>France/Kafka: An Author in Theory</em>
No full textJohn T. Hamilton, France/Kafka: An Author in Theor
The auto-biography of John Britton ...
No full text"A chronological list of the literary works of John Britton": vol. 3, p. [185-192]."Essays on the merits and characteristics of William Shakspere... " (vol. 3, p. [1]-48) has special t.-p.Vol. 3 has title: Appendix to Britton's Auto-biography containing biographical, archaeological, and critical essays ... London, Printed for the subscribers to the Britton testimonial, 1850.Vol. 2 has title: A descriptive account of the literary works of John Britton ... (from 1800 to 1849) ... by T. E. Jones. London, Printed for the subscribers to the testimonial, 1849."Royal octavo ... Five hundred copies of this size are printed."Mode of access: Internet.SML By6z B77 +849b: Includes "Notice" (1 l. following vol. 1, p. [xiv]), listing the editions in which the work was published, and "Subscribers to the Britton testimonial" ([4] p. following vol. 1, p. 396).SML By6z B77 +849b: "A chronological list of the literary works of John Britton": vol. 3, p. [169-176].SML By6z B77 +849b: "Essays on the merits and characteristics of William Shakspere ... (vol. 3, p. [1]-44) has special t.-p.SML By6z B77 +849b: "The quarto copies, which have been printed after the octavos, contain some literal corrections, and a few additional paragraphs."SML By6z B77 +849b: Title of vol. 2 and vol. 3 as in octavo edition.SML By6z B77 +849b: Added engraved t.-p. in vol. 1.SML By6z B77 +849b: "Demy quarto ... Only one hundred and twenty-five copies ... are printed of this size."SML By6z B77 +849b: Another edition. 3 v. in 2 : ill. ; 29 x 23 cm.SML By6z B77 849 Copy 2: "Preparing for publication. The auto-biography of John Britton ... London, Printed for the author, 1847": 7, [1] p. bound at end of vol. 1.SML By6z B77 849 Copy 2: "Notice," listing the editions in which the work was published, inserted in vol. 1, following p. xiv.SML By6z B77 849 Copy 1: "Subscribers to the Britton memorial" ([4] p.) inserted in vol. 1, following p. xiv
Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity
No full textCTLA-4 is a crucial immune checkpoint receptor involved in the maintenance of immune homeostasis, tolerance, and tumor control. Antibodies targeting CTLA-4 have been promising treatments for numerous cancers, but the mechanistic basis of their anti-tumoral immune-boosting effects is poorly understood. Although the ctla4 gene also encodes an alternatively spliced soluble variant (sCTLA-4), preclinical/clinical evaluation of anti-CTLA-4-based immunotherapies have not considered the contribution of this isoform. Here, we explore the functional properties of sCTLA-4 and evaluate the efficacy of isoform-specific anti-sCTLA-4 antibody targeting in a murine cancer model. We show that expression of sCTLA-4 by tumor cells suppresses CD8+ T cells in vitro and accelerates growth and experimental metastasis of murine tumors in vivo. These effects were accompanied by modification of the immune infiltrate, notably restraining CD8+ T cells in a non-cytotoxic state. sCTLA-4 blockade with isoform-specific antibody reversed this restraint, enhancing intratumoral CD8+ T cell activation and cytolytic potential, correlating with therapeutic efficacy and tumor control. This previously unappreciated role of sCTLA-4 suggests that the biology and function of multi-gene products of immune checkpoint receptors need to be fully elucidated for improved mechanistic understanding of cancer immunotherapies
There and Back piece recounting author John McDonald\u27s childhood story about t
No full textThere and Back piece recounting author John McDonald\u27s childhood story about the day his thoughts of doctors changed. While at the store, a young McDonald overhears the story of the murder at the old Tingley House - allegedly committed by Dr. Chase, a local physician
Other title: Ethiopia superior
No full textPrime meridian: Cape Verde; Relief shown pictorially.; Watermark; Includes illustrations and decorative cartouche
Other title: Nova Hispania, Nova Galicia, Guatimala
No full textLatitude scale shown, but not longitude.; Relief shown pictorially.; Cartouche includes scene of European trading with Native Americans.; Cartouche is fully colored.; Compass rose in lower center.; Appears in John Ogilby"s America and Arnoldus Montanus' De nieuwe en onbekende weerel
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Pop Chronicles Interviews
No full textRecording of John Gilliland interviewing author and critic George T. Simon for the Pop Chronicles radio program series
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