1,115 research outputs found
Craft so long to learn
No full textSpeech delivered by George Connor, identified by the author as "one of the 2 or 3 most signifcant speeches in my career.
Craft so long to learn
No full textSpeech delivered by George Connor, identified by the author as "one of the 2 or 3 most signifcant speeches in my career.
Jere Nash Interview with Peggy Connor
No full textInterview conducted by author Jere Nash with Peggy Connor as research for Mississippi Politics: The Struggle for Power, 1976-2006. Connor was the lead plaintiff in the case Connor v. Johnson on legislative voting districts in Mississippi. Topics covered include Connor\u27s family, background, and her participation in the civil rights movement; Fannie Lou Hamer; attempting to integrate precinct meeting and registering to vote; Mississippi Freedom Democratic Party; 1964 Democratic National Convention; Connor v. Johnson lawsuit; and civil rights demonstrations in Hattiesburg, Mississippi
Cutting'aesthetic teeth' : Flannery O'Connor's habit of art
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e ExpressãoEste trabalho foi sugerido pela afirmação de Flannery O'Connor que sua "dedicação estética" nasceu através do contato com Art and Scholasticism de Jacques Maritain. O propósito foi chegar a uma interpretação do sentido da frase. Uma investigação detalhada foi feita do conteúdo de Art and Scholasticism, posteriormente contrastada com os resultados de uma pesquisa feita em seus ensaios e suas cartas, o que revelou numerosos ecos de diversos trechos constando no texto de Maritain. Três pontos principais foram escolhidos como critérios na análise do hábito artístico de O'Connor: 1) a prática de arte implica uma luta; 2) a arte somente pode ser percebida pelos sentidos; e 3) a prática de arte exige do artista a dedicação indivisa à obra nascente. O estudo conclui que, para O'Connor, o brotar da dentição estética, através da leitura de Art and Scholasticism, significou que, ao perceber na análise da natureza da arte algo com que podia concordar, ela reconheceu tanto sua própria capacidade de tornar-se uma artista literária, quanto sua vontade de assumir a tarefa de desenvolver em sua pessoa o hábito de arte
Factor structure and psychometric properties of the Connor-Davidson Resilience Scale among Chinese adolescents
No full textObjectives: Resilience refers to psychological characteristics that promote effective coping and positive adaptation in adversity. This study investigated the factor structure and psychometric properties of the Chinese version of the Connor-Davidson Resilience Scale (CD-RISC) among adolescents
The modernity of nations. A tribute to Walker Connor
No full textTo fully appreciate Walker Connor's contribution to the foundation of the contemporary study of nationalism, two main factors must be taken into account. First, the context of positivist behavioural political science within which in the late 1960s and throughout the 1970s, he articulated his critique of the concept of nation-building. In this context, Connor emerged as a critic of the limitations and the naivité of positivist modernization theory. His dissenting voice called for critical rethinking and revision of the central concepts of the theory of political development, some of which enjoyed almost doctrinal status. Second, despite his criticism of modernization theory, Connor retained a strong conviction that nations and national sentiment were the products of modernity; indeed, in his judgement, they formed the primary content of modernity. This too was a critical stance within the rising tide of nationalism studies since 1989–1990, when ideology and wishful thinking influenced to a considerable extent the interpretation of nationalism. Walker Connor's intellectual legacy should thus be understood as a heritage of critical thought that is informed by a noteworthy awareness of the moral responsibilities of scholarly analysis. © The author(s) 2018. Nations and Nationalism © ASEN/John Wiley & Sons Ltd 201
Under-City - Connor Doyle (Faculty of Arts, English Literature and Creative Writing)
No full textcreative writingCanadian poetrystudent magazinesConnor Doyle is a poet and prose writer who recently graduated from KPU with a double major in Creative Writing and English Literature. Actively engaged in the writing community, Connor is the co-founder and managing editor for Pulp magazine, a magazine operated and owned by KPU students for students
New Perspectives on the Frontier Wars. "The Australian Frontier Wars 1788–1838" by John Connor. [review]
No full textIn the aftermath of the ideological jousts between Henry Reynolds and Keith Windschuttle about the level of violence on the colonial frontier, a new book has appeared that tackles the issue from a fresh perspective. The author, John Connor, is a military historian. In this meticulously researched and highly readable book, he uses the methods of military history to examine the weapons, tactics and conduct of warfare on the Australian frontier during the first fifty years of British colonisation. Connor emerges from the fray with exciting new findings.Australia Council, La Trobe University, National Library of Australia, Holding Redlich, Arts Victori
The molecular evolution of rectal cancer
No full textColorectal cancer (CRC) is a significant health burden, with rectal cancers accounting for approximately one-third of new diagnoses. With rectal cancers presenting as a distinct subset of CRCs in both their pathology and treatment, this work aimed to use next-generation sequencing to explore the molecular evolution of rectal tumours from adenomas to advanced carcinomas undergoing treatment, before exploring a specific subset of atypical BRAF mutant CRCs which appeared enriched in cancers of the distal colon and rectum. In a cohort of five patients with multi-region whole-genome sequencing (WGS) of large rectal adenomas that had yet to progress despite their size, no clonal molecular alterations associated with invasive carcinoma were found outside of truncal mutations in APC and KRAS. However, subclonal oncogenic mutations in TP53 and MYC were found in one patient (1/5, 20%). All tumours were microsatellite stable, and polygenic clonal evolution was observed between regions. Reconstructed tumour phylogenies suggested linear selective-sweeps operated early in development, followed by a switch towards branched evolution later in development to modulate tumour fitness more subtly. Focus was next shifted towards late-stage rectal cancers undergoing the selection pressure of neoadjuvant chemoradiotherapy. Longitudinally sampled rectal carcinoma tissue, or existing sequencing data, was obtained from the RHYTHM-I and XERXES clinical trials respectively. RHYTHM-I samples underwent WGS (5 patients) and RNA-seq (9 patients), whereas existing WGS data was leveraged for XERXES (6 patients). Somatic copy-number alterations and clonal heterogeneity underwent the largest changes between the pre-treatment and first-dose timepoints, and mutation signatures associated with chemoradiotherapy were observed in some samples. Finally, a combined cohort of sequencing data for 7,478 CRCs was assembled to characterise so-called atypical (class 2 or 3) BRAF-mutant CRCs, due to their apparent enrichment in the distal colon and rectum, which contrasts the canonical BRAF V600E variant (class 1). These classes of BRAF mutation are rarer, and paradoxically have reduced (class 2) or absent (class 3) kinase activity relative to class 1. The dataset consisted of 708 class 1 (9.47%), 33 class 2 (0.44%), and 90 class 3 (1.2%) BRAF mutant CRCs. These tumours were associated with the distal colon and rectum (60.7% class 2 and 59.2% class 3), microsatellite stability (0% and 4.9% MSI), and concomitant Ras pathway mutations (27.3% and 47.7%) – many of which were atypical in CRC themselves. Patients with atypical BRAF mutations had a better prognosis than those with V600E mutations, however concomitant Ras mutation may attenuate this affect. Conditional mouse models of class 3 mutant Braf homologous to BRAF G466V, D594N, and D594G were developed for use in future work further exploring atypical BRAF. In conclusion, this work provides additional insight into the dynamic nature of molecular evolution within rectal cancers throughout development and treatment. Rectal tumours are not constrained to a single model of clonal evolution, shifting from a series of early selective-sweeps towards a more branched model of evolution later in development. For late-stage rectal carcinomas undergoing neoadjuvant chemoradiotherapy, the earliest doses appear to have the greatest effect on tumour heterogeneity, likely through the loss of highly-vulnerable subclones. This study further provides new insights into the distinct subset of atypical BRAF mutant CRCs, particularly in that they appear to amplify existing Ras signalling following a two-mutation mini-driver model of cancer evolution, in addition to exhibiting distinct clinicopathological characteristics that contrast strongly with the canonical view of BRAF mutant CRC
Patrick Edward Connor and the Military District of Utah: Civil War Military Operations in Utah and Nevada, 1862-1865
No full textTroops, requested by the federal government for the security during the Civil War of the overland mail, telegraph, and emigrant routes, were provided by California for those portions of the routes which crossed the territories of Utah and Nevada. A force, never exceeding 1,200 in strength, commanded by Patrick Edward Connor, was assigned a geographic responsibility, the Military District of Utah.
Connor\u27s California Volunteers established principal troop locations at Fort Churchill and Fort Ruby in Nevada, and at Camp Douglas and Fort Bridger in Utah Territory during mid-1862. Major actions were conducted against the Indians at the battle of Bear River and by the campaign of Spanish Fork canyon, both in early 1863. Thereafter, a series of treaties achieved peace with various Indian tribes.
Connor also utilized his troops in a variety of activities peripheral to his primary military mission. Important examples were a colonization effort at Soda Springs, continued and thorough area reconnaissance, and early efforts to develop the territorial mineral resources.
Considerations of Mormon intentions, often believed by Connor to be inimical to Union interests, occupied much of Connor\u27s time.
Many writers record a generally unfavorable impression of Connor in Utah. However, it is the view of this author that the missions assigned to the federal troops in the District of Utah during the Civil War were important and were effectively carried out
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