1,729,092 research outputs found
Supplemental Material - Ruptured Pancreaticoduodenal Artery Aneurysm in a Patient With Celiac Artery Dissection: A Case Report
No full textSupplemental Material for Ruptured Pancreaticoduodenal Artery Aneurysm in a Patient With Celiac Artery Dissection: A Case Report by Jiyoung Shin, Hyun Pyo Hong, and Young-Wook Kim in Vascular and Endovascular Surgery</p
sj-docx-1-jaf-10.1177_0148558X231170077 – Supplemental material for Customer Concentration and Income Smoothing Activities
No full textSupplemental material, sj-docx-1-jaf-10.1177_0148558X231170077 for Customer Concentration and Income Smoothing Activities by Boochun Jung, Tae Wook Kim, Sang Hyun Park and Sung Wook Yoon in Journal of Accounting, Auditing & Finance</p
Supplemental Material, Kim_Kim_Oh_et_al_Online_Supplement - Community Analysis of a Crisis Response Network
No full textSupplemental Material, Kim_Kim_Oh_et_al_Online_Supplement for Community Analysis of a Crisis Response Network by Yushim Kim, Jihong Kim, Seong Soo Oh, Sang-Wook Kim, Minyoung Ku and Jaehyuk Cha in Social Science Computer Review</p
A Novel Physics-Infused Recurrent Neural Network for Health Monitoring of Lithium-Ion Batteries
No full text1
Phospholipase C-beta 1 Hypofunction in the Pathogenesis of Schizophrenia
Full text linkSchizophrenia is a mental disorder that is characterized by various abnormal symptoms. Previous studies indicate decreased expression of phospholipase c-beta 1 (PLc-beta 1) in the brains of patients with schizophrenia. PLC-beta 1 -null (PLC-beta 1) mice exhibit multiple endophenotypes of schizophrenia. Furthermore, a study of PLC beta 1 knockdown in the medial prefrontal cortex of mice has shown a specific behavioral deficit, impaired working memory. These results support the notion that disruption of PLC-beta 1-linked signaling in the brain is strongly involved in the pathogenesis of schizophrenia. In this review, we broadly investigate recent studies regarding schizophrenia-related behaviors as well as their various clinical and biological correlates in PLC-beta 1- and knockdown mouse models. This will provide a better understanding of the pathological relevance of the altered expression of PLC p1 in the brains of patients with schizophrenia. Evidence accumulated will shed light on future in-depth studies, possibly in human subjects.1341scopu
The translational regulation of cofilin mRNA by hnRNP Q and hnRNP A1 promotes the formation of cofilin-actin rod during cerebral ischemia
No full textCerebral ischemia, caused by insufficient blood supply to the
brain, can lead to significant neurodegeneration in different parts
of the brain. Cofilin actin rods, a covalently bound aggregate of
cofilin-1 and actin, are known to induce the neurodegeneration
during cerebral ischemia by interrupting the intracellular trafficking
of the neuron. These cofilin-actin rods are formed by increased
expression of cofilin, an actin binding protein that depolymerizes
actin filament, under high oxidative stress condition. However, the
regulatory mechanism behind the expression of cofilin under the
disease condition remains unclear. Here, we found that RNA
binding protein hnRNP Q and hnRNP A1 regulate the translation of
cofilin mRNA by interacting with the internal ribosome entry site
(IRES) of cofilin mRNA. We demonstrated that hnRNP Q blocks
the interaction between cofilin mRNA and hnRNP A1, which
reduces the translational activity of cofilin mRNA. In addition, we
found that this binding pattern between hnRNP Q and hnRNP A1
changes in primary hippocampal neurons under ischemic
condition due to the re-localization of these proteins. The altered
binding pattern further increased translation activity of cofilin
mRNA. Finally, we observed the inhibition of cofilin-actin rod
formation when we modulated the expression of hnRNP Q or
hnRNP A1 in primary hippocampal neuron under ischemic
condition. Taken together, our results revealed a new translational
regulatory mechanism of cofilin mRNA, which provides insights to
the formation of cofilin-actin rod during cerebral ischemia.1
Expression of Genes Involved in Axon Guidance: How Much Have We Learned?
No full textNeuronal axons are guided to their target during the development of the brain. Axon guidance allows the formation of intricate neural circuits that control the function of the brain, and thus the behavior. As the axons travel in the brain to find their target, they encounter various axon guidance cues, which interact with the receptors on the tip of the growth cone to permit growth along different signaling pathways. Although many scientists have performed numerous studies on axon guidance signaling pathways, we still have an incomplete understanding of the axon guidance system. Lately, studies on axon guidance have shifted from studying the signal transduction pathways to studying other molecular features of axon guidance, such as the gene expression. These new studies present evidence for different molecular features that broaden our understanding of axon guidance. Hence, in this review we will introduce recent studies that illustrate different molecular features of axon guidance. In particular, we will review literature that demonstrates how axon guidance cues and receptors regulate local translation of axonal genes and how the expression of guidance cues and receptors are regulated both transcriptionally and post-transcriptionally. Moreover, we will highlight the pathological relevance of axon guidance molecules to specific diseases.11Ysciescopu
sj-pdf-1-imr-10.1177_03000605221104768 - Supplemental material for Association of bladder trabeculation and neurogenic bladder with spinal cord injury
No full textSupplemental material, sj-pdf-1-imr-10.1177_03000605221104768 for Association of bladder trabeculation and neurogenic bladder with spinal cord injury by Yu Hui Won, Da-Sol Kim, Gi-Wook Kim, Sung-Hee Park, Myoung-Hwan Ko and Jeong-Hwan Seo in Journal of International Medical Research</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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