653 research outputs found
sj-docx-1-isp-10.1177_00207640231161301 – Supplemental material for Double stigma in mental health service use: Experience from ethnic minorities in Hong Kong
No full textSupplemental material, sj-docx-1-isp-10.1177_00207640231161301 for Double stigma in mental health service use: Experience from ethnic minorities in Hong Kong by Suen Yi Nam, Wong Yik Chun, Wong Tak Hing Michael, Chan Kit Wa Sherry, Hui Lai Ming Christy, Lee Ho Ming Edwin and Chen Yu Hai Eric in International Journal of Social Psychiatry</p
sj-docx-1-isp-10.1177_00207640231152691 – Supplemental material for Unpacking the mediating role of resilience in the relationship between ideal-actual self-discrepancy, stressful life events, depression and anxiety: Results from 1,144 young people in an epidemiological study in Hong Kong
No full textSupplemental material, sj-docx-1-isp-10.1177_00207640231152691 for Unpacking the mediating role of resilience in the relationship between ideal-actual self-discrepancy, stressful life events, depression and anxiety: Results from 1,144 young people in an epidemiological study in Hong Kong by Suen Yi Nam, Ling Cheuk Ying Crystal, Cheung Charlton, Hui Lai Ming Christy, Wong Ming Yin Stephanie, Wong Tak Hing Michael, Chan Kit Wa Sherry, Lee Ho Ming Edwin and Chen Yu Hai Eric in International Journal of Social Psychiatry</p
Supplementary_material_1 – Supplemental material for Feasibility of predictive model by clinical and laboratory parameters for risk stratification of geriatric abdominal pain
No full textSupplemental material, Supplementary_material_1 for Feasibility of predictive model by clinical and laboratory parameters for risk stratification of geriatric abdominal pain by Chun Tat Lui, Wei Ming Ching, Kwok Leung Tsui, Ho Cheung Chu, Alex To Shing Tsui, Tak Shun Au, Tai Wai Wong, Kit Ling Fan and Ling Pong Leung in Hong Kong Journal of Emergency Medicine</p
APHERP symposium session IV : Higher education, job opportunities and transgenerational inequality
No full textPresented Titles: Massification and Transnationalisation of Higher Education: Challenges for Graduate Employment and Transgenerational Inequality in China [Authors: Joshua Ka-ho Mok; Guo-guo Ke; Tian Zhen] Expanding Higher Education during Economic Downturns: Why China’s Lessons are Hard to Learn From? [Authors: Wing-kit Chan; Jiarun Li] Multiple Factors Affecting Graduate Employability: What Implications for Graduates? [Authors: Yuzhuo Cai; Yulia Shumilova] Graduate Employability and Labour Market Relevance of Norwegian Higher Education: Perspectives from Students [Author: Dian Liu
Hong Kong's competitive position in the Asia/Pacific region: perspective of multi-national corporations' telecommunication needs.
No full textby Johnathan, Wong Ho-Man, Sin Wai-Kit.Thesis (M.B.A.)--Chinese University of Hong Kong, 1992.Includes bibliographical references (leaves 79-83).ABSTRACT --- p.iiLIST OF TABLES --- p.viiiPREFACE --- p.ixCHAPTERChapter I. --- INTRODUCTION --- p.1Importance of MNCs --- p.1MNCs' Regional Headquarters Location Decisions --- p.2Business/Technology Trends and Telecommunications --- p.3Trends in the Telecommunications Industry --- p.5The Asia Pacific Era and Telecommunications --- p.6Competition with Telecommunications --- p.6Research Questions --- p.7Organization of This Paper --- p.7Chapter II. --- METHODOLOGY --- p.9Setting the Scene --- p.9Literature Review --- p.10Personal Interviews --- p.11Chapter III. --- REGIONAL HEADQUARTERS LOCATION DECISION OF MNCS --- p.16Functions of a Regional Headquarters --- p.16Profile of MNCs' Regional Headquarters in Hong Kong and Singapore --- p.17Factors in the Regional Headquarters Location Decision --- p.18Comparative Advantages of Hong Kong and Singapore --- p.20Common Strengths --- p.20Common Weaknesses --- p.21Unique Attractions and Operation Relocation Patterns --- p.21Administrative Headquarters vs Telecommunications Hub --- p.22Summary --- p.24Chapter IV. --- TELECOMMUNICATIONS NEEDS OF MNCS --- p.25General Observations --- p.25Role of Telecommunications --- p.27Applications and Use of Telecommunications Services --- p.28"Issues in Telecom Planning, Implementation, and Management" --- p.31Quality in Delivery of Telecommunications Services --- p.31Quality in Customer Service --- p.31Basic Needs --- p.32Provision of Value-Added Professional Services --- p.32One-Stop Shopping and Support --- p.33Flexibility --- p.33Availability --- p.33Capacity --- p.34Other Issues --- p.34Summary --- p.34Chapter V. --- TELECOMMUNICATIONS INFRASTRUCTURES/DEVELOPMENTS --- p.36Country Status Review --- p.36Japan --- p.37Australia --- p.37South Korea --- p.38Singapore --- p.38Hong Kong --- p.39Country Performance as Assessed by MNCs --- p.40Chapter VI. --- LOCAL INFRASTRUCTURE ISSUES --- p.44Time of Changes --- p.44Historical Background --- p.45Liberalization Trend --- p.46HKTI Franchise --- p.46External Pressure --- p.47Newcomers --- p.48Political Issue --- p.48Interview Input --- p.49Second Physical Network --- p.50Deregulated Scenario --- p.50Scheme of Control --- p.52Regulatory Framework --- p.53Chapter VII. --- RECOMMENDATIONS --- p.54Hong Kong Telecom and Hong Kong Telecom International --- p.54"Policy : Market Review, Transparency and Government Initiative" --- p.54Regulatory Bodies --- p.56Chapter VIII. --- CONCLUSION --- p.58Chapter APPENDIX A. --- Telecommunications Infrastructures and Services --- p.61Chapter APPENDIX B. --- List of Interview Subjects --- p.63Chapter APPENDIX C. --- Question Areas for MNC Interviews --- p.66Chapter APPENDIX D. --- Convergence Pattern of Interviewee Referrals --- p.68Chapter APPENDIX E. --- Cover Letter for Interview Request --- p.69Chapter APPENDIX F. --- Heenan's 16 Dimensions in the MNC Survey --- p.70Chapter APPENDIX G. --- Tables --- p.71Chapter APPENDIX H. --- Glossary of Telecommunications Terms --- p.78BIBLIOGRAPHY --- p.7
POST ARCHITECTURE : THE SHIFT FROM CLOSED AND EXQUISITE TO OPEN AND ORDINARY
No full textMaster'sMASTER OF ARCHITECTURE (M.ARCH
Hong Kong cinema 1982-2002 : the quest for identity during transition
No full textElectronic redacted version excludes material for which permission has not been granted by the rights holderThis thesis seeks to interpret the cinematic representations of Hong Kongers’ identity quest during a transitional state/stage related to the sovereignty transfer. The Handover transition considered is an ideological one, rather than the overnight polity change on the Handover day. This research approaches contemporary Hong Kong cinema on two fronts and the thesis is structured accordingly: Upon an initial review of the existing Hong Kong film scholarship in the Introduction, and its 1997-related allegorical readings, Part I sees new angles (previously undeveloped or underdeveloped) for researching Hong Kong films made during 1982-2002. Arguments are built along the ideas of Hong Kongers’ situational, diasporic consciousness, and transformed ‘Chineseness’ because Hong Kong has lacked a cultural/national centrality. This part of research is informed by the ideas of Jacques Derrida, Homi Bhabha and Stuart Hall, and the diasporic experiences of Ien Ang, Rey Chow and Ackbar Abbas. With these new research angles and references to the circumstances, Part II reads critically the text of eight Hong Kong films made during the Handover transition. In chronological order, they are Boat People (Hui, 1982), Song of the Exile (Hui, 1990), Days of Being Wild (Wong, 1990), Happy Together (Wong, 1997), Made in Hong Kong (Chan, 1997), Ordinary Heroes (Hui, 1999), Durian Durian (Chan, 2000), and Hollywood Hong Kong (Chan, 2002). They meet several criteria related to the undeveloped / underdeveloped areas in the existing Hong Kong film scholarship. Hamid Naficy’s ‘accented cinema’ paradigm gives the guidelines to the film analysis in Part II. This part shows that Hong Kongers’ self-transformation during transition is alterable, indeterminate, and interminable, due to the people’s situational, diasporic consciousness, and transformed ‘Chineseness’. This thesis thus contributes to Hong Kong cinema scholarship in interpreting films with new research angles, and generating new insights into this cinematic tradition and its wider context
Abstract 436: Folate cycle represents a new metabolic vulnerability for hepatocellular carcinoma treatment
No full textAbstract
Hepatocellular carcinoma (HCC), primary liver cancer, ranks the third most lethal cancer worldwide due to late symptom presentation and lack of promising curative therapy. Metabolic reprogramming has been recognized as a major and new hallmark of cancer in recent years. Better understanding of its underpinning molecular mechanisms favoring cancer growth will be crucial for the development of effective HCC therapeutics. The folate cycle fuels metabolic processes and the production of metabolites essential to cell growth and tumorigenesis maintenance. Through the shuttling of a single carbon unit by a folate derivative through the tetrahydrofolate (THF) backbone in the cytoplasmic and mitochondrial compartments, metabolites like NADPH - a major cellular antioxidant for redox balance, s-adenosyl methionine (SAM) - precursor of DNA and histone methylation, and pyrimidine and purine - the building blocks of DNA are produced. We found folate to be indispensable for HCC cell growth. Furthermore, methylene-THF dehydrogenase 1-like (MTHFD1L), a key enzyme facilitating the folate cycle from the mitochondria, was found to be significantly up-regulated in HCC with association to poorer clinical features for patients. Genetic inhibition of MTHFD1L by knockdown and knockout by shRNA and CRISPR-Cas9 systems, respectively, blocked NADPH production. Rapid elevation in oxidative stress induced DNA damage and cell cycle delay; ultimately inhibiting HCC proliferation. Binding of the transcription factor NRF2, a potent protector of oxidative stress, and MTHFD1L was confirmed by ChIP assay. NRF2 over-expression using the CRISPR-activating system in HCC cells further highlighted the dependent relationship between NRF2 and MTHFD1L. Metabolomics analysis showed that MTHFD1L knockdown caused a disruption to the folate cycle and accumulation of serine. Surprisingly, MTHFD1L knockdown did not reduce the levels of SAM and nucleotides. Knockdown of MTHFD1L in HCC cells significantly inhibited primary liver tumor growth and lung metastasis in orthotopic liver implantation model. Therapeutically, the administration of methotrexate, an anti-folate agent, sensitized HCC cells towards Sorafenib treatment both in vitro and vivo. The folate cycle represents a metabolic vulnerability and attractive therapeutic target for HCC. Inhibition of MTHFD1L disrupts the folate cycle and sensitizes HCC cells towards its convention treatment agent, Sorafenib in various HCC mouse models. Our investigation unravels a metabolic vulnerability in cancer which contributes to better understanding and is beneficial for the development of precise inhibitors specifically targeting associated pathways.
Citation Format: Derek Lee, Iris Ming-Jing Xu, David Kung-Chun Chiu, Robin Kit-Ho Lai, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong. Folate cycle represents a new metabolic vulnerability for hepatocellular carcinoma treatment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 436. doi:10.1158/1538-7445.AM2017-436</jats:p
CUHK electronic theses & dissertations collection
No full textTsang, Kit Man.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 125-137).Abstracts also in Chinese.Title from PDF title page (viewed on 04, November, 2016)
Avaliação da estrutura genética da população atual de Santa Catarina com diferentes marcadores moleculares para aplicação na genética forense
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2014A identificação genética humana está centrada na utilização de um conjunto de marcadores autossômicos denominado microssatélite (Short Tanden Repeats-STRs). Todavia em algumas situações, como indivíduos com alto grau de parentesco, casos de deficiência paterna, amostras biológicas degradadas ou pouca quantidade, têm-se focado na utilização de outras classes de marcadores genéticos: inserções/deleções (InDels), do cromossomo X (X-STRs), do cromossomo Y (Y-STRs) e na região hipervariável 1 do DNA mitocondrial (mtDNA-HVR1). Visando avaliar a extensão da diversidade genética da população de Santa Catarina, indivíduos não aparentados foram genotipados para os marcadores do tipo (1) InDels, incluídos no Investigator DIPplex Kit®, (2) STRs autossômicos, incluídos no Investigator HDplexTM Kit®, (3) miniSTRs, incluídos no Investigator Hexaplex ESS Kit®, (4) STRs do cromossomo X, através do Investigator Argus X-12 Kit®. Foram determinadas as frequências alélicas e heterozigoses observada e esperada (Ho e He), e a eficácia dos parâmetros forenses: Poder de Discriminação (PD), Probabilidade de Coincidência (PC), Índice de Paternidade Típico (TPI), Poder de Exclusão de Paternidade (PE) e Conteúdo da Informação Polimórfica (PIC), sendo que não foi observado nenhum desvio (pAbstract: Human genetic identification is centered on use of microsatellite markers (Short Tanden Repeats-STRs). However, in some situations as individuals with a high degree of kinship, cases of paternal disability, degraded biological samples and in low amounts of samples have been focused on the use of other markers such as: insertions/deletions (InDels), X chromosome markers (X-STRs), Y chromosome markers (Y-STRs) and hypervariable region 1 of mitochondrial DNA (HVR1-mtDNA). Thereby, to evaluate the extent of genetic diversity of the Santa Catarina population, unrelated individuals were genotyped for: (1) InDels markers, included in the DIPplex Investigator DIPplex Kit®, (2) autosomal STRs, included in the Investigator HDplexTM Kit®, (3) miniSTRs, included in the Investigator Hexaplex ESS Kit® and (4) the X chromosome STRs, through the Investigator Argus X -12 Kit®. Allele frequencies, observed and expected heterozygosity (Ho, He) were determined, and the effectiveness of forensic parameters such as Power of Discrimination (PD), Probability of Coincidence (PC), Typical Paternity Index (TPI), Paternity Exclusion Power (PE) and Polymorphic Information Content (PIC). No deviation was observed (p <0.05) for the loci analyzed, except DXS10135 and DXS1079 Investigator Argus X-12 Kit®. All loci showed a high degree of genetic polymorphism. The highest PIC was observed in SE33 (0.948) and the lowest was observed in D6S474 (0.745). Forensic parameters were calculated based on allele frequencies for the Investigator HDplexTM and Investigator Hexaplex ESS® Kits. Combined Discrimination Power (CDP) and Combined Power of Exclusion (PEC) were 0.999999999999999999997752854927 and 0.99999999978062285, respectively. Allele frequencies for the 16 analyzed STR loci were compared with those of other populations from different geographical distributions. Genetic distance (Dsw) showed proximity between the Santa Catarina population, the European populations (France, Italy) and the sampled African population. The second group consisted of populations that do not significantly participated in the formation of Brazilian identity (Japan, Mexico, Colombia) and two isolated populations of Amerindian from Brazil. Allele frequencies and the statistical parameters of the Investigator Argus X-12 Kit® were obtained and the most polymorphic marker was DXS10135 with 23 polymorphic alleles and less polymorphic marker was DXS8378 with 5 alleles. Power of discrimination in Females (PDF) was 0.9999999999999999103669, while the Power of Discrimination in Males (PDM) was 0.999999999688867. Combined Power of Exclusionfor Trios and Duos were 0.99999999867687 and 0.999999589803, respectively. Linkage Disequilibrium tests were performed for all pairs of loci and only DXS7132-DXS10074 remained significant after Bonferroni correction (p < 0.0008). Analysis of genetic distance was used and it was verified that the population of Santa Catarina had similarity with European populations (Germany, Denmark and Portugal) followed by North African populations (Morocco and Somalia) and distant from the populations of Shanghai and Greenland because these populations not participate in the formation of the Santa Catarina identity. Another objective of this project were the genetic characterization of the variability of patrilineal population of Santa Catarina through seventeen STRs located in a non-recombinant region of the Y chromosome, included in the AmpFISTR®YfilerTM Kit. After analysis, 305 haplotypes were identified and 292 of these were unique (96%). Comparing the results obtained in this study with data from Portuguese, Spanish, Italians, Germans, Africans and other Brazilian populations was observed the important contribution of Europeans from the Iberian Peninsula in the composition of the Santa Catarina population. Variability of matrilineal population of Santa Catarina was also characterized by the sequencing of the mtDNA hypervariable region 1 (mtDNA-HVR1). This technique was the standardized and implemented in the Forensic Genetics section of the Instituto Geral de Perícias do Estado de SC (IGP-SC). During the data analysis, 221 haplotypes (n = 342) were identified, these haplotypes were classified into 85 geographic subhaplogrupos. Considering the largest haplogroups, these results showed an important contribution of the European haplogroup H (32.16%). Amerindian haplogroups A, B, C and D represent 25.15% of the population in contrast to the African haplogroup L that totalize 7.02%. Besides the genetic contribution for the understanding of the history of Santa Catarina population, the realization of this thesis resulted in the implementation of new techniques in the Forensic Genetics section of the IGP-SC, including sixty new genetic markers in their analysis and the mitochondrial DNA sequencing to solve the forensic cases of high complexity
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