41 research outputs found
Medical Marijuana Education for Medical Students
No full textThis project includes a report, poster presentation, and a presentation slide deck.As the nationwide discourse on medical marijuana evolves, with 28 out of 50 states approving its use, University of Massachusetts Medical School graduates will need to be prepared to discuss medical marijuana (MMJ) with their patients. There is currently no formal medical school education on MMJ. This project set out to understand the curriculum gap and provide a learning session to interested students. The presentation was created using research done by the author during the first three years of medical school, including visits to private MMJ clinics. Utilizing a pre/post-session online assessment of a group of twenty-six students, we found that student knowledge about Massachusetts’ MMJ law improved by 29%, following a ninety-minute session. In addition, self-assessed confidence in negotiating clinical scenarios involving marijuana improved by 34%. These improvements were statistically significant, with p-values of 0.0033 and 9.5x10-16 respectively. These findings support the formal addition of a sixty- to ninety-minute session focusing on MMJ to the UMMS curriculum
Book Review: Impression Management in the Workplace: Research, Theory and Practice
No full textAuthor: ANDREW J. DUBRIN, Routledge, New York (2011), pp. 23
Book Review: Selling Destinations: Geography for The Travel Professional
No full textAuthor: Marc Mancini (Toronto: Nelson Education, 2013, 5th Edition, xii + 611 pp., paperback, ISBN 978-0-17-650008-5
An analysis of Malawi\'s publication productivity
No full textBackground: Publications productivity, the number of scientific articles published, is a measure of a country's scientific output. If measured carefully it can be a useful indicator that describes a countries' research activity. Our objective was to analyze trends in publications originating from Malawi between 1996 – 2006.
Methods: The MEDLINE/PubMed database, a registry of articles from over 5,000 scientific journals was searched for articles originating from Malawi between 1996 – 2006 by typing Malawi in the author affiliation search field. A review of abstracts was performed to determine health field and origin of first author – Malawian vs foreign.
Results: 506 articles were retrieved of which 489 were on health. 15.5% on TB, 14.5% on HIV and AIDS, 11.2% on infectious disease, 7.2% on TB and HIV, 7.2% on Malaria. 20.9% of the authors were of Malawian origin and Tropical Doctor was the journal that had the most articles originating from Malawi. The number of articles published from Malawi has grown by 106% in the past ten years.
Conclusions: Our results suggest there is growth in scientific publishing in Malawi but the main contribution is from foreign researchers residing in Malawi. More needs to be done to promote publishing by Malawian authors. Malawi Medical Journal Vol. 20 (3) 2008: pp. 90-9
Strong Factorizations of Operators with Applications to Fourier and Cesaro Transforms
No full text[EN] Consider two continuous linear operators T: X-1 (mu) -> Y-1 (nu) and S: X-2 (mu) -> Y-2 (nu) between Banach function spaces related to different sigma-finite measures mu and nu. By means of weighted norm inequalities we characterize when T can be strongly factored through S, that is, when there exist functions g and h such that T(f) = gS(hf) for all f is an element of X-1 (mu). For the case of spaces with Schauder basis, our characterization can be improved, as we show when S is, for instance, the Fourier or Cesar operator. Our aim is to study the case where the map T is besides injective. Then we say that it is a representing operator-in the sense that it allows us to represent each element of the Banach function space X (mu) by a sequence of generalized Fourier coefficients-providing a complete characterization of these maps in terms of weighted norm inequalities. We also provide some examples and applications involving recent results on the Hausdorff-Young and the Hardy-Littlewood inequalities for operators on weighted Banach function spaces.The first author gratefully acknowledge the support of the Ministerio de Economia y Competitividad (project #MTM2015-65888-C4-1-P) and the Junta de Andalucia (project FQM-7276), Spain. The second author was supported by National Science Centre, Poland, project no. 2015/17/B/ST1/00064. The third author acknowledges with thanks the support of the Ministerio de Economia y Competitividad (project MTM2016-77054-C2-1-P), Spain.Delgado Garrido, O.; Mastylo, M.; Sánchez Pérez, EA. (2019). Strong Factorizations of Operators with Applications to Fourier and Cesaro Transforms. The Michigan Mathematical Journal. 68(1):167-192. https://doi.org/10.1307/mmj/1548817532S16719268
Noncommutative resolutions and rational singularities
No full textLet k be an algebraically closed field of characteristic zero. We show that the centre of a homologically homogeneous, finitely generated k-algebra has rational singularities. In particular if a finitely generated normal commutative k-algebra has a noncommutative crepant resolution, as introduced by the second author, then it has rational singularities
The Implication of Using NVivo Software in Qualitative Data Analysis: Evidence-Based Reflections
No full textFor a long time, electronic data analysis has been associated with quantitative methods. However, Computer Assisted Qualitative Data Analysis Software (CAQDAS) are increasingly being developed. Although the CAQDAS has been there for decades, very few qualitative health researchers report using it. This may be due to the difficulties that one has to go through to master the software and the misconceptions that are associated with using CAQDAS. While the issue of mastering CAQDAS has received ample attention, little has been done to address the misconceptions associated with CAQDAS. In this paper, the author reflects on his experience of interacting with one of the popular CAQDAS (NVivo) in order to provide evidence-based implications of using the software. The key message is that unlike statistical software, the main function of CAQDAS is not to analyse data but rather to aid the analysis process, which the researcher must always remain in control of. In other words, researchers must equally know that no software can analyse qualitative data. CAQDAS are basically data management packages, which support the researcher during analysis
Bone marrow-derived mononuclear cells therapy for ischemic stroke
No full textLaboratory of Tissue Engineering and Cells Culture, Department of Neurology No 1,
Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: Nowadays, the cerebrovascular event is the second cause of death and the third cause of disability worldwide. In the last few decades, stem
cell-based approaches are widely analyzed as a potential treatment for this disease. One of these types of cells are bone marrow-derived mononuclear
cells (BMMNCs).
In this review, we analyzed 9 completed clinical trials with the use of BMMNCs in patients with ischemic stroke, which we found in the clinicaltrials.
gov and PubMed databases, using the keywords “stroke“ and “bone marrow mononuclear cells”. Our goal was to analyze the safety and efficiency of this
therapeutic approach, as well as the optimal therapeutic time window, transplantation route and cell dose used.
The best stroke phase to apply this therapy is the subacute stage. Higher numbers of CD34+ cells, derived from BMMNCs were correlated with a trend
toward a better outcome. All the clinical trials support the idea that BMMNCs transplantation is a safe therapy.
Conclusions: In conclusion the author points out that the autologous transplantation of BMMNCs is harmless and not associated with severe complications.
Although some clinical studies stated a better outcome in patients treated with BMMNCs, further clinical trials are needed to establish their therapeutic
efficienc
Stability Conditions for Slodowy Slices and Real Variations of Stability
No full textThe paper provides new examples of an explicit submanifold in
Bridgeland stabilities space of a local Calabi-Yau. More precisely, let X be the standard resolution of a transversal slice to an adjoint nilpotent orbit of a simple Lie algebra over C. An action of the affine braid group on the derived category D[superscript b] (Coh(X)) and a collection of t-structures on this category permuted by the action have been constructed in [BR] and [BM] respectively. In this note we show that the t-structures come from points in a certain connected submanifold in the space of Bridgeland
stability conditions. The submanifold is a covering of a submanifold in the
dual space to the Grothendieck group, and the affine braid group acts by deck transformations. We also propose a new variant of definition of stabilities on a triangulated category, which we call a ”real variation of stability conditions” and discuss its relation to Bridgeland’s definition. The main theorem provides an illustration of such a relation. We state a conjecture by the second author and A. Okounkov on examples of this structure arising from symplectic resolutions of singularities and its relation to equivariant quantum cohomology. We verify this conjecture in our examples
TNBC-DX genomic test in early-stage triple-negative breast cancer treated with neoadjuvant taxane-based therapy
No full textBackground: Identification of biomarkers to optimize treatment strategies for early-stage triple-negative breast cancer (TNBC) is crucial. This study presents the development and validation of TNBC-DX, a novel test aimed at predicting both short- and long-term outcomes in early-stage TNBC. The objective of this study was to evaluate the association between TNBC-DX and efficacy outcomes [pathologic complete response (pCR), distant disease-free survival (DDFS) or event-free survival (EFS), and overall survival (OS)] in the validation cohorts. Methods: Information from 1259 patients with early-stage TNBC (SCAN-B, CALGB-40603, and BrighTNess) was used to establish the TNBC-DX scores. Independent validation of TNBC-DX was carried out in three studies: (i) WSG-ADAPT-TN; (ii) MMJ-CAR-2014-01; and (iii) NeoPACT, including 527 patients with stage I-III TNBC undergoing neoadjuvant chemotherapy. In WSG-ADAPT-TN, patients were randomized to receive nab-paclitaxel plus gemcitabine or carboplatin. In MMJ-CAR-2014-01, patients received carboplatin plus docetaxel. In NeoPACT, patients received carboplatin plus docetaxel and pembrolizumab. Results: TNBC-DX test was created incorporating the 10-gene Core Immune Gene module, the 4-gene tumor cell proliferation signature, tumor size, and nodal staging. In the two independent validation cohorts without pembrolizumab, the TNBC-DX pCR score was significantly associated with pCR after adjustment for clinicopathological variables and treatment regimen [odds ratio per 10-unit increment 1.34, 95% confidence interval (CI) 1.20-1.52, P < 0.001]. pCR rates for the TNBC-DX pCR-high, pCR-medium, and pCR-low categories were 56.3%, 53.6%, and 22.5% respectively (odds ratio for pCR-high versus pCR-low 3.48, 95% CI 1.72-7.15, P < 0.001). In addition, the TNBC-DX risk score was significantly associated with DDFS [hazard ratio (HR) high-risk versus low-risk 0.24, 95% CI 0.15-0.41, P < 0.001] and OS (HR 0.19, 95% CI 0.11-0.35, P < 0.001). In the validation cohort with pembrolizumab, the TNBC-DX scores were significantly associated with pCR, EFS, and OS. Conclusions: TNBC-DX predicts pCR to neoadjuvant taxane–carboplatin in stage I-III TNBC and helps to forecast the patient's long-term survival in the absence of neoadjuvant anthracycline–cyclophosphamide, and independent of pembrolizumab use. © 2024 The Author(s
