41,542 research outputs found
P Values and Statistical Significance
No full textThis resource, created by author Will G. Hopkins, defines what a p-value is, why .05 is significant, and when to use it. It also covers related topics such as one-tailed/two-tailed tests and hypothesis testing. Overall, this is a wonderful resource for students wanting to learn more about statistics, and more specially, significant testing
Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD
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Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Phagocytosis by inflammatory phagocytes; experimental strategies for stimulation and quantification
No full textPhagocytosis is perhaps the key goal to which the activity of myeloid cells such as neutrophils and macrophages is directed. In vivo, neutrophils triggered to leave the blood stream, migrate through the extracellular matrix (ECM) and are guided to sources of microbes in order to kill them after phagocytosis. Methods for quantifying this event in vitro are therefore useful in the experimental assessment of agents and conditions that may modify the phagocytic ability of the phagocyt
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations.
No full textHuman dysplastic kidneys are developmental aberrations which are responsible for many of the very young children with chronic renal failure. They contain poorly differentiated metanephric cells in addition to metaplastic elements. We recently demonstrated that apoptosis was prominent in undifferentiated cells around dysplastic tubules (Winyard, P.J.D., J. Nauta, D.S. Lirenman, P. Hardman, V.R. Sams, R.A. Risdon, and A.S. Woolf. 1996. Kidney Int. 49:135-146), perhaps explaining the tendency of some of these organs to regress. In contrast, apoptosis was rare in dysplastic epithelia which are thought to be ureteric bud malformations. On occasion, these tubules form cysts which distend the abdominal cavity (the multicystic dysplastic kidney) and dysplastic kidneys may rarely become malignant. We now demonstrate that dysplastic tubules maintain a high rate of proliferation postnatally and that PAX2, a potentially oncogenic transcription factor, is expressed in these epithelia. In contrast, both cell proliferation and PAX2 are downregulated during normal maturation of human collecting ducts. We demonstrate that BCL2, a protein which prevents apoptosis in renal mesenchymal to epithelia] conversion, is expressed ectopically in dysplastic kidney epithelia. We propose that dysplastic cyst formation may be understood in terms of aberrant temporal and spatial expression of master genes which are tightly regulated in the normal program of human nephrogenesis
Linguaggio, simbolo, memoria. Pico e l’ircocervo
No full textThis article examines the role of language, symbols, and memory in the thought of Giovanni Pico della Mirandola, focusing on a particular passage in his Apologia where he mentions the "hircocervus". The author explores the meaning of this symbol, linking it to medieval philosophical debates on intelligibility and truth, as well as to the Kabbalistic tradition. By analyzing Pico’s sources a connection emerges between the "hircocervus" and Flavius Mithridates’ translation of the Song of Songs, highlighting the complex interplay between philosophy, Kabbalah, and the art of memory in Renaissance thought. At the same time, this symbol provides a crucial clue for investigating Pico’s mnemonic structures
La construcción de un ethos común en “Don de gentes” de Elvira Lindo. Una interacción a distancia
No full textABSTRACT
This paper, within the general framework of orality studied in this volume, studies the relation between writing and orality in the press and, more specifically, in editorials. It is also based on recent research that highlighted the presence of orality traits in written press and editorials, as well as in the emerging study of Elvira Lindo’s language and its implications for translation. The analysis includes the presence of thauthor’s self in the statement, as well as the identification of the recipient with whom the author shares opinions and proposes a motivating ethos on various topics with an agile and personal style characterized by humour and irony. At discourse level, the analysis focuses on some of the main features of colloquial syntax, and namely the use conjunctions in discourse function and discourse markers as marks of subjectivity and of the relation with the reader.RESUMEN
En este estudio, enmarcado en el ámbito general de la oralidad del presente volumen, se investiga la relación existente entre escritura y oralidad en el sector de la prensa, y más concretamente en el de la columna de opinión. Se enmarca también en una serie de investigaciones recientes que han evidenciado la presencia de rasgos de oralidad en la prensa escrita y en las columnas de opinión, así como en el todavía incipiente estudio del lenguaje de Elvira Lindo y de sus dificultades de traducción. Se propone para ello el análisis de la presencia del yo del autor en el enunciado, así como la identificación del destinatario con el que comparte una serie de opiniones y propone un motivador ethos sobre diferentes temas con un estilo ágil y personal veteado de humor e ironía. En el plano discursivo se analizan algunos de los rasgos que caracterizan la sintaxis coloquial, para lo que se ha considerado i) el uso de conjunciones en función discursiva; ii) el uso de marcadores discursivos como marcas de la subjetividad y de la relación con el lector
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