2,915 research outputs found
Dietary Terpenoid Lactones are Promiscuous Agonists of Bitter Taste Receptors (TAS2Rs)
No full textThe observation that a lactone ring is present in structurally distinct natural classes of sesquiterpenoid and diterpenoid activators of bitter receptor TAS2R46 provided a rationale to investigate the potency of a set of these natural products across the whole range of human bitter receptors. TAS2Rs are responsible for detecting bitter taste and, with some exceptions, are broadly tuned to recognize a wide range of compounds. The ectopical expression of TAS2Rs suggests additional role(s) beyond sensory perception, but no general bitter chemotype has emerged so far to inspire the design of a specific agonist. From our study, a complex pattern of TAS2Rs activation emerged, showing that the lactone pharmacophore is not specific for TAS2R46 but, depending on its framework, can also activate different sets of taste receptors. Taken together, our results expand the role of the lactone ring as a bitter chemotype and qualify dietary terpenoid lactones as excellent lead for the design of specific bitter receptors modulators
CAPRI versus AGLINK-COSIMO: Two partial equilibrium models - Two baseline approaches
No full textThe agricultural modelling world has generated several models aiming at the analysis of the response of the sector to certain changes in exogenous mainly policy variables. Among those, the CAPRI modelling system developed by a consortium centred on the University of Bonn and the AGLINK-COSIMO model, a joint product of the OECD and the FAO, are well known and accepted as comprehensive tools. This analysis focuses on a qualitative comparison of both models and particularly on the process of setting up the baseline. The baseline is a medium-term projection of agricultural markets reflecting current policies and those already decided upon. This projection in turn serves as the base for comparisons when analyzing scenarios. It is shown that CAPRI uses generic and automatic procedures whenever possible for conducting the database and the baseline, while AGLINK-COSIMO puts more emphasis on expert knowledge in this process. Both approaches are shown to have certain advantages while the conclusion that a combination of them would potentially improve both models will be drawn from this analysis.CAPRI, AGLINK-COSIMO, Baseline process, Agricultural and Food Policy,
After the Addendum: Author Rights Management and/as Library Service
No full textThis report presents the findings from a qualitative study of Rice University faculty attitudes and practices around author rights conducted by Marcel LaFlamme, a graduate student in the Department of Anthropology, during his tenure as a Fondren Fellow. This project was supervised by Shannon Kipphut-Smith, Fondren Library’s scholarly communications liaison
Glucosinolates in Sisymbrium officinale (L.) Scop. : Comparative Analysis in Cultivated and Wild Plants and in Vitro Assays with T2Rs Bitter Taste Receptors
No full textSisymbrium officinale (L.) Scop., commonly known as “hedge mustard” or “the singer’s plant” is a wild plant common in Eurasian regions. Its cultivation is mainly dedicated to herboristic applications and it has been only recently introduced into Italy. The active botanicals in S. officinale are glucosinolates, generally estimated by UV or HPLC. Using both techniques we measured the total glucosinolates from S. officinale in different parts of the plant as roots, leaves, seeds and flowers. A comparison was made for cultivated and wild samples, and for samples obtained with different pre-treatment and storage conditions as fresh, frozen and dried. Cultivated and wild plants have a comparable amount of total glucosinolates; drying procedures can reduce the final glucosinolates content. The content in glucoputranjivin, which is the chemical marker for glucosinolates in S. officinale, has been determined by HPLC using a pure reference standard. Glucoputranjivin and two isothiocyanates from S. officinale have been submitted to in vitro assays with the platform of bitter taste receptors of the T2Rs family; the results show that glucoputranjivin is a selective agonist of receptor T2R16
Ruskin traduzido: Sesame and Lilies por Proust e Catalán
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Literatura, Florianópolis, 2009.Este trabalho parte da análise das traduções da obra Sesame and Lilies, de John Ruskin, para o francês e para o castelhano para fazer um exame de questões ligadas ao gênero ensaístico, à tradução de ensaios e à autoria. Para isso, analisarei a tradução de Marcel Proust para o francês e seu paratexto e a tradução para o castelhano feita por Miguel Catalán e o respectivo paratexto.This study analises the translations of Sesame and Lilies, by John Ruskin, into French and Spanish in order to examine issues related to the essay as a literary genre, to the translation of essays and to authorship. This exam will be carried out by analising the translation into French by Marcel Proust and its paratext and the translation into Spanish by Miguel Catalán, accompanied by its paratext
Jean-Marcel Jeanneney à l'OFCE - Fondations et contributions (1981-1989).
No full textJean-Marcel Jeanneney était un économiste rare, à la fois théoricien, empiriste et praticien. C’est son aventure à la tête de l’OFCE que ce livre raconte, ou plutôt qu’il laisse l’auteur lui-même conter au travers d’articles écrits depuis le premier jour de son premier mandat de Président de notre institution. Ce recueil s’ouvre sur une introduction qui rappelle l'attachement du fondateur de l’OFCE au « libéralisme intellectuel», cette indépendance vis-à-vis des idées reçues qu’il jugeait indispensable à la conduite de politiques publiques raisonnables. Il est ensuite structuré en trois parties dont les titres font écho à une oe uvre marquante de Jean-Marcel Jeanneney : Vouloir le débat public en économie, Une mémoire au service de la prospective et Écoute le monde qui vient : intégration globale et unification européenne. Ce volume est un hommage à la mémoire de Jean-Marcel Jeanneney mais plus encore à sa présence. Les textes rassemblés ici par Jean-Paul Fitoussi et Éloi Laurent nous rappellent l’actualité des enseignements les plus précieux de Jean-Marcel Jeanneney : honnêteté, courage et espérance.
Some Marks in Marcel Iancu’s Creation
No full textThe paper emphasises some aspects of Marcel Iancu’s creation during his dadaist period in Zürich and after his return in Romania where he was one of avant-garde movement leaders and author of some important theoretical articles
Data for: Author Ranking Evaluation at Scale
No full textThis data consists of two test data sets of researchers that have (1) received one or more prestigious prizes for the long-lasting and high impact contribution to their fields (596 data entries) and (2) author names of ACM fellows (1000 data entries).Each author in the data sets is matched to the corresponding ACM author profileID and multiple Microsoft Academic Graph author entity IDs (name disambiguated). It also includes citation counts, publication counts, download counts from various sources (ACM Digital Library, Google Scholar, Microsoft Academic)
Marcel Schwob Digital Collection
No full textThis project outlines the discovery and digitization of previously unpublished correspondence composed by late 19th century author and literary critic, Marcel Schwob. Inspired by the inquiry of Bibliothèque Nationale Librarian Bernard Gauthier, Professor Daryl Lee alerted me to the presence of Marcel Schwob materials at BYU. I found that former BYU Professor John Green established a Marcel Schwob Memorial Collection and successfully published two books using the materials he gathered: Chroniques and Correspondance Inédite. After thoroughly researching the catalogued Schwob materials at BYU and comparing the contents to other Schwob publications, I found 72 previously unpublished letters. The majority of the letters (62) were written by Schwob to family members, and the remaining 9 letters were written to Schwob by colleagues. International interest in Marcel Schwob materials is one of many indicators representing renewed interest in the author, his work, and his influence. Recent publications also reflect growing Schwob interest. In Marcel Schwob, d\u27hier et d\u27aujourd\u27hui (2002), Christian Berg and Yves Vadé shed new light on Schwob through the observations of his contemporaries and modern-day essays on the importance of his contes. In addition, Jean Lorrain: Lettres à Marcel Schwob (2006) furthers the effort to better understand Schwob through a collection of correspondence. In light of this renewed interest, I determined that the previously unpublished correspondence would serve as a useful research tool for Schwob scholars. With the guidance and assistance of employees at the Harold B. Lee Library, I subsequently converted the correspondence into a digital publication. Creating a digital publication is a multifaceted undertaking requiring the involvement and expertise of different individuals and library departments. I successfully learned how to use both the hardware and software involved in the digitization process, thereby facilitating my completion of project deliverables, including: scanning and transcribing the letters; writing letter summaries (in both French and English), extracting names, and completing other metadata; uploading metadata using the Lee Library\u27s external database; establishing authority control records; writing website content (in both French and English), and publicizing the project. This document contains the major deliverables found in the digital publication, specifically the website content, the letter transcriptions, and the metadata
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