2,905 research outputs found
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
Get PDFIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by MC-RR
No full textAs cynobacterial blooms frequently occur in fresh waters throughout the world, microcystins (MCs) have caused serious damage to both wildlife and human health. MCs are known to have developmental toxicity, however, the possible molecular mechanism is largely unknown. This is the first toxicological study to integrate post-transcriptomic, proteomic and bioinformatics analysis to explore molecular mechanisms for developmental toxicity of MCs in zebrafish. After being microinjected directly into embryos, MC-RR dose-dependently decreased survival rates and increased malformation rates of embryos, causing various embryo abnormalities including loss of vascular integrity and hemorrhage. Expressions of 31 microRNAs (miRNAs) and 78 proteins were significantly affected at 72 hours post-fertilisation (hpf). Expressions of miR-430 and miR-125 families were also significantly changed. The altered expressions of miR-31 and miR-126 were likely responsible for the loss of vascular integrity. MC-RR significantly reduced the expressions of a number of proteins involved in energy metabolism, cell division, protein synthesis, cytoskeleton maintenance, response to stress and DNA replication. Bioinformatics analysis shows that several aberrantly expressed miRNAs and proteins (involved in various molecular pathways) were predicted to be potential MC-responsive miRNA-target pairs, and that their aberrant expressions should be the possible molecular mechanisms for the various developmental defects caused by MC-RR
The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR
No full textMicrocystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress.Microcystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress
So Tom has turned a poet, what a dear [first line]
No full textstrophicnasame as Box 192 Item 50Cover is duplicated in 192.050.
Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnasame as Box 192 Item 50Cover is duplicated in 192.050.
Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnaCover is duplicated in 192.051.
Music is duplicated in 192.051.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 050Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnaCover is duplicated in 192.051.
Music is duplicated in 192.051.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 050Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
FPGA-accelerated calculation of the correlation integral of RR intervals
No full textAnaliza sygnałów biomedycznych jest jednym z ważniejszych obszarów badań naukowych. Istnieje duże zapotrzebowanie na wydajne systemy obliczeniowe, które pozwalały by na analizę sygnałów biomedycznych wielu pacjentów. W artykule przedstawiono propozycję architektury systemu obliczającego całkę korelacji interwałów międzyuderzeniowych RR, wykorzystującego układ FPGA do akceleracji obliczeń.Biomedical signal analysis is a very important field of research. This paper describes architecture of FPGA-accelerated computational system proposed by Author. The main purpose of this system is calculation of the correlation integral of RR intervals in cardiological patients
Implementasi Canva dalam Digitalisasi Mata Pelajaran Seni Budaya Untuk Meningkatkan Keaktifan dan Hasil belajar Siswa
No full textTujuan – Penelitian ini bertujuan mendeskripsikan implementasi Canva dalam digitalisasi mata pelajaran seni budaya pada siswa kelas VIIIB MTsN 1 Yogyakarta.
Metode – Penelitian ini menggunakan pendekatan kualitatif deskriptif. Subjek penelitian terdiri dari guru seni budaya dan siswa kelas VIIIB di MTsN 1 Yogyakarta yang menggunakan Canva dalam pembelajaran mereka. Data dikumpulkan melalui wawancara mendalam, observasi, dan dokumentasi. Metode analisis konten digunakan untuk menganalisis data yang terkumpul. Validitas data diperoleh melalui triangulasi data dari berbagai sumber.
Hasil – Hasil penelitian menunjukkan bahwa penggunaan Canva dalam pembelajaran seni budaya di MTsN 1 Yogyakarta meningkatkan minat dan pemahaman siswa terhadap materi. Guru dapat efektif menyampaikan materi seni rupa melalui aplikasi Canva, terutama dalam pembuatan poster dan komik. Implementasi Canva didukung oleh program Madrasah Digital dari Kementerian Agama, melibatkan komitmen, dukungan, partisipasi, dan pendanaan. Inovasi pembelajaran Canva menjadi solusi dalam meningkatkan kualitas pembelajaran seni budaya di era digital, mengatasi kendala dalam pendidikan, dan menjawab tuntutan zaman yang semakin maju. Penelitian ini memberikan kontribusi penting dalam pengembangan metode pembelajaran yang inovatif dan rekomendasi bagi guru dalam menggunakan Canva sebagai alat bantu pembelajaran di masa depan. Implementasi Canva dalam pembelajaran seni budaya di MTsN 1 Yogyakarta adalah contoh bagaimana inovasi pendidikan dapat mengatasi kendala dan menjawab tuntutan zaman
Peningkatan Keaktifan dan Hasil Belajar Siswa Melalui Penerapan Aplikasi Canva pada Materi Pembuatan Poster di MTs Negeri 1 Yogyakarta
No full textThis study aims to improve student activeness and learning outcomes in learning Cultural Arts poster making materials. This research using the Classroom Action Research (PTK) method was carried out in 2 cycles. The subjects of the study were students in class VIII-C MTs Negeri 1 Yogyakarta. Data is obtained from teachers (observers) and students through observation, tests, and documentation. The results showed that student activeness and learning outcomes in the learning process through the application of the Canva application have increased significantly. In the first cycle, an average class score of 81.06 was obtained with classical learning completeness of 83.87 with the category of students being quite active. In cycle II, the average grade score increased to 87.71 with classical learning completeness reaching 100% with the active student category. The application of the Canva application in learning Cultural Arts poster making materials can increase student activeness and learning outcomes
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