187,003 research outputs found
Importance of Aggregated Islet Amyloid Polypeptide for the Progressive Beta-Cell Failure in Type 2 Diabetes and in Transplanted Human Islets
No full textOriginal Publication: Gunilla Westermark and Per Westermark, Importance of Aggregated Islet Amyloid Polypeptide for the Progressive Beta-Cell Failure in Type 2 Diabetes and in Transplanted Human Islets, 2008, EXPERIMENTAL DIABETES RESEARCH, (2008), 528354. http://dx.doi.org/10.1155/2008/528354 Copyright: Authors</p
The systemic amyloidoses: clearer understanding of the molecular mechanisms offers hope for more effective therapies.
No full textFibrils from designed non-amyloid-related synthetic peptides induce AA-amyloidosis during inflammation in an animal model
No full textBackground: Mouse AA-amyloidosis is a transmissible disease by a prion-like mechanism where amyloid fibrils act by seeding. Synthetic peptides with no amyloid relationship can assemble into amyloid-like fibrils and these may have seeding capacity for amyloid proteins. Principal Findings: Several synthetic peptides, designed for nanotechnology, have been examined for their ability to produce fibrils with Congo red affinity and concomitant green birefringence, affinity for thioflavin S and to accelerate AA-amyloidosis in mice. It is shown that some amphiphilic fibril-forming peptides not only produced Congo red birefringence and showed affinity for thioflavin S, but they also shortened the lag phase for systemic AA-amyloidosis in mice when they were given intravenously at the time of inflammatory induction with silver nitride. Peptides, not forming amyloid-like fibrils, did not have such properties. Conclusions: These observations should caution researchers and those who work with synthetic peptides and their derivatives to be aware of the potential health concerns. © 2009 Westermark et al.Original Publication:P. Westermark, Katarzyna Lundmark and Gunilla Westermark, Fibrils from designed non-amyloid-related synthetic peptides induce AA-amyloidosis during inflammation in an animal model, 2009, PLoS ONE, (4), 6, e6041.http://dx.doi.org/10.1371/journal.pone.000604
Transthyretin and Amyloid in the Islets of Langerhans in Type-2 Diabetes
No full textTransthyretin (TTR) is a major amyloid fibril protein in certain systemic forms of amyloidosis. It is a plasma protein, mainly synthesized by the liver but expression occurs also at certain minor locations, including the endocrine cells in the islets of Langerhans. With the use of immunohistochemistry and in situ hybridization, we have studied the distribution of transthyretincontaining cells in islets of Langerhans in type-2 diabetic and nondiabetic individuals. TTR expression was particularly seen in alpha (glucagon) cells. Islets from type-2 diabetic patients had proportionally more transthyretin-reactive islet cells, including beta cells. A weak transthyretin immunoreaction in IAPP-derived amyloid occurred in some specimens. In seeding experiments in vitro, we found that TTR fibrils did not seed IAPP while IAPP fibrils seeded TTR. It is suggested that islet expression of transthyretin may be altered in type-2 diabetes.Original Publication: Gunilla Westermark and Per Westermark, Transthyretin and Amyloid in the Islets of Langerhans in Type-2 Diabetes, 2008, EXPERIMENTAL DIABETES RESEARCH, (2008), 429274. http://dx.doi.org/10.1155/2008/429274 Copyright: Authors</p
Restaureringen av Bosgårdens lerstall - Tema: Tillämpning [Elektronisk resurs]
No full textStallbyggnaden på Bosgården iBorgå, Finland, kanske inte äger något högt kulturhistoriskt värde i sig, men dess byggnadsteknik har fascinerat arkitekterna Leticia Achcar, Stockholm, och Mikael Westermark, Helsingfors. Restaureringen av stallbyggnaden blev för dem ett intressant experiment i lerhusbyggande. </p
Otto Mørkholm, Early Hellenistic Coinage. From the Accession of Alexander to the Peace ofApamea (336-188 B.C.). Éd. par P. Grierson et U. Westermark
No full textde Callataÿ François. Otto Mørkholm, Early Hellenistic Coinage. From the Accession of Alexander to the Peace ofApamea (336-188 B.C.). Éd. par P. Grierson et U. Westermark. In: L'antiquité classique, Tome 64, 1995. pp. 439-441
15. Mørkholm (Otto), Early Hellenistic Coinage from the Accession of Alexander to the Peace of Apamea (336-188 BC), edited by Philip Grierson and Ulla Westermark
No full textLe Rider Georges. 15. Mørkholm (Otto), Early Hellenistic Coinage from the Accession of Alexander to the Peace of Apamea (336-188 BC), edited by Philip Grierson and Ulla Westermark. In: Revue des Études Grecques, tome 105, fascicule 500-501, Janvier-juin 1992. p. 274
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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