491 research outputs found
Ethnofuturism and Place-Making : Bengt Pohjanen's Construction of Meänmaa
No full textThe article examines the Tornedalian author Bengt Pohjanen’s construction of Meänmaa [literally ‘Our land’] through an analysis of a selection of texts in which the concept “Meänmaa” is used. Meänmaa refers to the border area between Sweden and Finland in the Torne Valley. The making of Meänmaa is related to ethnofuturism, an aesthetic program launched in Estonia in the 1980s. Its aim is to strengthen threatened Uralic cultures and languages. The conclusion presented is that ethnofuturism provides a framework for present-day identity formation and the making of a specific place called Meänmaa against the backdrop of a history of assimilationist policies and marginalisation
Stig Dagerman
No full textSpecial feature issue on the Swedish author Stig Dagerman (1923-1954) with editorial by Anders Hallengren and original contributions by Johan Cullberg, Lotta Lotass, Tom Karlsson, Urban Forsgren, Bengt Söderhäll (2), Björn Ranelid, Bert Ekengren and Jöran Mjöberg along with texts by the author.</p
Platelet-derived growth factor in glioblastoma-driver or biomarker?
No full textThe platelet-derived growth factor (PDGF) family of mitogens exerts vital functions during embryonal development, e.g. in the central nervous system, where PDGF drives the proliferation of oligodendrocyte precursors. PDGF and PDGF receptors are co-expressed in human glioblastoma (GBM). Whether an aberrant activation of the PDGF receptor pathway is a driving force in glioma development has remained an open question. In experimental animals, overexpression of PDGF has convincingly been shown to induce tumors, both in wild-type animals (marmoset, rat, mouse) and in mice with targeted deletions of suppressor genes, e.g. Tp53 or Ink4A. Targeting the PDGF receptor in tumor-bearing mice leads to growth inhibition and reversion of the transformed phenotype. Findings of PDGF receptor amplification or mutations in human GBM are strong indicators of a causative role of the PDGF receptor pathway. However, clinical trials using PDGF receptor antagonists have been disappointing. In conclusion, a PDGF receptor profile may be a biomarker for a subgroup of GBM originating from a PDGF receptor-responsive cell. Although compelling experimental and clinical evidence supports the notion that the PDGF receptor pathway is a driver in GBM, formal proof is still missing.</p
Bengt Gottfried Forselius und die Quellen der Volksbildung in Est- und Livland
No full textVäitekirja elektrooniline versioon ei sisalda kuuendat artiklit (polnud kaitsmise ajaks ilmunud).Väitekiri käsitleb Bengt Gottfried Forseliuse (u 1660–1688) tegevust eesti talurahvakoolide rajamisel ja kirjakeele (written language) uuendmisel. Töö eesmärgiks on allikalise baasi laiendamine, seniste uurimuste kriitiline hindamine ning uus, täpsustatud lähteandmetel tuginev rekonstruktsioon. Uurimus on interdistsiplinaarne ning asetab vaadeldud teemad laiemasse ajaloolisse ja kultuurilisse konteksti. Haridusajalooline ja biograafilis-prosopograafiline käsitlus põimub pedagoogika, lingvistika, ideeajaloo ning raamatuteaduse teemadega, samuti on püütud ühendada mikro- ja makroajalugu, s.t lokaalajaloolist vaatepunkti vastavate arengutega naabermaades. Töö koosneb katuspeatükist ja kuuest artiklist (neist üks ilmumas). Artiklid käsitlevad talurahvakoolide asutamist Eesti- ja Liivimaal 17. sajandi lõpul, sotsiaalseid ja etnilisi vahekordi rannarootsi asustusega Harju-Madise ja Risti kihelkonnas, Johannes Haquini Forseliust (rektori ja vaimulikuna) ning Bengt Gottfried Forseliust kui koolide asutajat, keeleuuendajat ja innovaatilise aabitsa autorit. Mitme distsipliini ja erinevate uurimisperspektiivide ühendamine võimaldab mitte ükses täpsustada faktoloogiat, vaid pakub senistest erinevaid kontseptuaalseid järeldusi.The thesis examines the activities of Bengt Gottfried Forselius (approx. 1660–1688) in regard to the founding of Estonian peasant schools and innovation of the written language. The objective of the research is the expansion of the base of sources, critical evaluation of the existing investigations and a new, specified reconstruction. The research is interdisciplinary and places the observed topics in the broader historical and cultural context. The educational history and biographic-prosopographical approach interweaves with the themes of pedagogy, linguistics, history of ideas and bibliognosy. Likewise, the reunification of micro- and macrohistory was intended: the perspective of local history and the respective developments in the neighbouring countries. The dissertation consists of the main chapter and six articles (one of them unpublished). The articles examine the founding of the peasant schools in Estland and Livland at the end of the 17th century, social and ethnic relations with the Coastal Swedes’ settlements in the Harju-Madise and Risti (St. Matthias & Kreuz) parishes, Johannes Haquini Forselius (as a rector and pastor) and Bengt Gottfried Forselius as the organizer of schools, reformer of orthography and the author of the innovative primer. The unification of various disciplines and distinct perspectives of research enables not only to concretize factology but provides new conceptual conclusions
Le meilleur professeur est un éternel étudiant. Bengt Hambraeus, compositeur et pédagogue
No full textUn ancien étudiant du compositeur d’origine suédoise Bengt Hambraeus dresse un portrait chaleureux de ce dernier. Il passe en revue les principales étapes de sa formation d’organiste, de musicologue et de compositeur et il souligne sa participation active à la vie musicale suédoise en qualité de producteur à la radio d’État. L’auteur explique ensuite les motifs qui ont conduit Hambraeus à émigrer au Canada en 1972. Débute alors sa fructueuse carrière de pédagogue à la Faculté de musique de l’université McGill, à Montréal. Il y assure, avec son collègue alcides lanza, la direction du studio de musique électroacoustique. Il y enseigne également la composition et propose différents cours et séminaires sur l’écriture et la musique d’avant-garde. Sa vaste expérience de musicien professionnel, sa curiosité insatiable, sa mémoire prodigieuse et sa capacité d’établir, à partir d’un sujet donné, des liens multiples avec différentes disciplines et époques de l’histoire de la musique sont particulièrement mis en valeur. Ces traits de caractère permettent de mieux comprendre les compositions de celui que ses élèves surnomment « l’encyclopédie vivante ».In this cordial portrait of Swedish-born composer Bengt Hambraeus by one of his former students, the principle stages in his education are reviewed : from organist to musicologist and composer, together with his active participation in Swedish musical life as a producer for state radio. The author then explains the reasons why, in 1972, Hambraeus immigrated to Canada, where he began a fruitful career in Montreal as a teacher at McGill University’s Faculty of Music. There he co-directed the Electronic Music Studio with his colleague alcides lanza. He also taught composition and various seminars on composing, and on the avant-garde. His vast experience as a professional musician, his insatiable curiosity, his prodigious memory and his capacity to establish (starting from a given topic) a multiplicity of links to different disciplines and periods of music history are highlighted. These character traits provide for a better understanding of the compositions whose author students called a “walking encyclopedia.
The Development of the Meänkieli in the Bengt Pohjanen’s Novels “Lyykeri” and “Jopparikuninkhaan poika”
No full textZviedrijas autohtonās valodas meänkieli vēsture sākas 1809. gadā, kad tagadējā Somijas teritorija tiek pievienota Krievijas impērijai. Lai arī kopš šī notikuma pagājuši 200 gadi, Tornedālenes somu valodai vēl nav izveidota standartizēta literārā valoda un runātajai valodai ir daudzas variācijas.
Pētījuma mērķis ir meänkieli salīdzinājums divos Bengta Pohjanena romānos – „Lyykeri” un „Jopparikuninkhaan poika” , kuri izdoti attiecīgi 1985. gadā un 2009. gadā, meklējot atšķirības valodas lietojumā. Darbā tiek analizētas arī meänkieli atšķirības no somu literārās valodas.
Pētījuma rezultāti rāda, ka meänkieli lietojumā ir vērojamas atšķirības. Lai arī tās nav lielas, tas pierāda valodas attīstību un mainīgumu, ņemot vērā, ka analīze veikta viena rakstnieka darbiem.
Atslēgvārdi: analīze, atšķirības, literārā valoda, meänkieli, salīdzinājums.The history of the Meänkieli starts in 1809 when the territory of modern-day Finland was added to the Russian Empire. Although the Meänkieli is the language with a history of 200 years, its normatives of the literary language have not strongly confirmed.
The purpose of the research paper is to contrast the development of the Meänkieli in the two novels of Bengt Pohjanen – Lyykeri and Jopparikuninkhaan poika, which have been published accordingly in 1985 and 2009. An important part of the research paper is also the analysis of differences between the Meänkieli and the Finnish. The investigation was based on gathering and reading of the available theory materials of the Meänkieli and comparing and contrasting the Meänkieli in two novels of one author.
The research revealed that the use of the Meänkieli differs in the novels of Bengt Pohjanen. Although the differences are not remarkable, it proves the development of the language, taking into account that the analysis is done in the works of one author.
Key words: analysis, contrast, differences, literary language, Meänkieli
CGGBP1-an indispensable protein with ubiquitous cytoprotective functions
No full textThe human genome contains multiple stretches of CGG trinucleotide repeats, which act as transcription- and translation-regulatory elements but at the same time form secondary structures that impede replication and give rise to sites of chromosome fragility. Proteins binding to such DNA elements may be involved in divergent cellular processes such as transcription, DNA damage, and epigenetic state of the chromatin. We review here the work done on CGG repeats and associated proteins with special focus on a factor called CGGBP1. CGGBP1 presents with an interesting example of factors that do not have any single dedicated function, but participate indispensably in multiple processes. Both experimental results and data from cancer genome sequencing have revealed that any alteration in CGGBP1 that compromises its function is not tolerated by normal or cancer cells alike. Based upon a large amount of published data, information from databases, and unpublished results, we decipher in this review how CGGBP1 is a classic example of the one factor, divergent functions' paradigm of cytoprotection. By taking cues from the studies on CGGBP1, more such factors can be discovered for a better understanding of the evolution of mechanisms of cellular survival.</p
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