1,843 research outputs found
Tumour hypoxia imaging with [F-18]FAZA PET in head and neck cancer patients: a pilot study
No full textPurpose Hypoxia is an important negative prognostic factor for radiation treatment of head and neck cancer. This study was performed to evaluate the feasibility of use of F-18-labelled fluoroazomycin arabinoside ([F-18]FAZA) for clinical PET imaging of tumour hypoxia. Methods Eleven patients (age 59.6 +/- 9 years) with untreated advanced head and neck cancer were included. After injection of approximately 300 MBq of [F-18]FAZA, a dynamic sequence up to 60 min was acquired on an ECAT HR+ PET scanner. In addition, approximately 2 and 4 h p.i., static whole-body PET (n=5) or PET/CT (n=6) imaging was performed. PET data were reconstructed iteratively (OSEM) and fused with CT images (either an external CT or the CT of integrated PET/CT). Standardised uptake values (SUVs) and tumour-to-muscle (T/M) ratios were calculated in tumour and normal tissues. Also, the tumour volume displaying a T/M ratio > 1.5 was determined. Results Within the first 60 min of the dynamic sequence, the T/M ratio generally decreased, while generally increasing at later time points. At 2 h p.i., the tumour SUVmax and SUVmean were found to be 2.3 +/- 0.5 (range 1.5-3.4) and 1.4 +/- 0.3 (range 1.0-2.1), respectively. The mean T/M ratio at 2 h p.i. was 2.0 +/- 0.3 (range 1.6-2.4). The tumour volume displaying a T/M ratio above 1.5 was highly variable. At 2 h p.i., [F-18]FAZA organ distribution was determined as follows: kidney > gallbladder > liver > tumour > muscle > bone > brain > lung. Conclusion [F-18]FAZA PET imaging appears feasible in head and neck cancer patients, and the achieved image quality is adequate for clinical purposes. Based on our initial results, [F-18]FAZA warrants further evaluation as a hypoxia PET tracer for imaging of cancer
Hypoxia-specific tumor imaging with F-18-fluoroazomycin arabinoside
No full textThe study was performed to compare the F-18-labeled nitroimidazole compound fluoroazomycin arabinoside (F-18-FAZA) with the standard hypoxia tracer fluoromisonidazole (F-18-FMISO) in detection of tumor tissue hypoxia and to verify the oxygenation dependency of F-18-FAZA uptake. Methods: Biodistribution of F-18-FAZA was studied at various time points in EMT6 tumor-bearing BALB/c mice and in AR42J and A431 tumor-bearing nude mice and compared with that of F-18-FMISO. The presence of tumor tissue hypoxia was verified in 5 EMT6 and 5 AR42J tumors using an oxygen-sensing needle electrode system. To evaluate the oxygenation dependency of F-18-FAZA uptake, using the Munich prototype animal PET scanner, 2 serial PET scans were performed in 13 A431 tumor-bearing nude mice breathing pure oxygen or room air on 1 d and then selecting the other oxygen breathing condition on the following day. In addition, digital autoradiography was performed with EMT6 tumor-bearing F-18-FAZA-dosed, nude mice breathing either room air (n = 8) or carbogen (n = 9). Results: Tissue partial pressure of oxygen (Po-2) electrode measurements revealed that tumor hypoxia was present under room air breathing in EMT6 (tissue Po-2 = 2.9 +/- 2.6) and AR42J tumors (tissue Po-2 = 0.4 +/- 0.2), which was significantly lower compared with that of reference tissue (tissue Po-2 = 25.8 +/- 6.7 and tissue Po-2 29.0 +/- 3.0 [mean +/- SD], respectively; P < 0.01). In all tumor models, F-18-FAZA displayed significantly higher tumor-to-muscle and tumor-to-blood ratios compared with F-18-FMISO, indicating a faster clearance of F-18-FAZA from normal tissues. In AR42J tumors, F-18-FAZA tumor-to-normal ratios were found to increase overtime. Serial animal F-18-FAZA PET studies showed that the tumor-to-background ratio was significantly higher in animals breathing room air compared with that of animals breathing pure oxygen (7.3 +/- 2.3 vs. 4.2 +/- 1.2, respectively; P < 0.001). Similarly, autoradiography showed significantly higher tumor-to-muscle ratios in mice breathing room air compared with those of animals breathing carbogen (5.3 +/- 0.8 vs. 2.2 +/- 0.8; respectively; P < 0.02). Conclusion: F-18-FAZA shows superior biokinetics and is, thus, a promising PET tracer for the visualization of tumor hypoxia. This study also verified a hypoxia-specific uptake mechanism for F-18-FAZA in murine tumor models
EVALUATION ON CONSISTENCY BETWEEN HJ-1 CCD AND TM IMAGES IN MONITORING FRACTIONAL GREEN VEGETATION COVER
No full textThe fractional green vegetation cover (Fc) is an important climate model parameter. Remote sensing technique has become one of the most effective means to acquire vegetation dynamics information. The CCD cameras onboard HJ-1 satellites (Environment and Disaster monitoring and forecasting Satellite constellation) are advanced in revisit frequency and image coverage compared with Landsat TM. This study aims to assess the capability of HJ-1 CCD images in monitoring of Fc in terms of comparing with the widely used TM images. The quality of HJ-1 CCD is compared with the same temporal TM image in two aspects: the image statistical analysis and the image application analysis. After the comparison between the HJ-1 CCD image and TM image of the same area. The results show a high level of uniform between HJ-1 and TM images. Therefore, the conclusion may be drawn that the HJ-1 CCD image is feasible and suitable for Fc monitoring.Engineering, Electrical & ElectronicGeosciences, MultidisciplinaryRemote SensingEICPCI-S(ISTP)
Konsep Pendidikan Untuk Perempuan Perspektif Nyai Hj. Masriyah Amva
No full textOne figure of a well-known female cleric in Cirebon is Nyai Hj. Masriyah Amva. He is a female ulama figure who is different from the others, Nyai Hj. Masriyah Amva became the caretaker of Kebon Jambu Al-Islamy Islamic Boarding School in Babakan Village, Ciwaringin Cirebon, where she became the leader of more than 1,000 male and female santri. The author presents this paper in the form of a qualitative approach, with qualitative descriptive methods, collection techniques using interview and observation methods, which are then analyzed by interactive analysis techniques namely data reduction, data presentation and drawing conclusions. This study aims to illustrate the Concept of Education for Perpective Women Nyai Hj. Masriyah Amva at Kebon Jambu Al-Islamy Islamic Boarding School. According to him, education for women consists of material elements, immaterial elements and character elements. The material element is education that equips students with various sciences according to their respective levels, while the immaterial element is that women are able to present and involve the Creator in all their life processes, according to Nyai Hj. Masriyah Amva, that is, women must be educated in such a way as to form a woman who is persistent, independent, has a personality, is pious and tough with hard prayers, hard efforts and always has positive thoughts.Salah satu sosok ulama perempuan yang sangat dikenal di Cirebon adalah Nyai Hj. Masriyah Amva. Beliau adalah sosok ulama perempuan yang berbeda dengan lainnya, Nyai Hj. Masriyah Amva menjadi pengasuh Pondok Pesantren Kebon Jambu Al-Islamy di Desa Babakan, Ciwaringin Cirebon, beliau menjadi pemimpin lebih dari 1.000 santri laki-laki dan perempuan. Penulis menyajikan tulisan ini dalam bentuk pendekatan kualitatif, dengan metode deskriptif kualitatif, teknik pengumpulan menggunakan metode wawancara dan observasi, yang kemudian dianalisis dengan teknik analisis interaktif yaitu reduksi data, penyajian data dan penarikan kesimpulan. Penelitian ini bertujuan untuk menggambarkan Konsep Pendidikan untuk Perempuan Perpektif Nyai Hj. Masriyah Amva di Pondok Pesantren Kebon Jambu Al-Islamy. Menurutya pendidikan untuk perempuan adanya unsur material, unsur imaterial dan unsur karakter. Unsur material adalah pendidikan yang membekali santrinya dengan berbagai ilmu pengetahuan sesuai jenjangnya masing-masing, sedangkan unsur Imaterial adalah para perempuan mampu menghadirkan dan melibatkan Sang Pencipta dalam semua proses kehidupannya, unsur karakter menurut Nyai Hj. Masriyah Amva yaitu perempuan harus dididik sedemikian rupa hingga terbentuklah sosok perempuan yang gigih, mandiri, berkepribadian, bertaqwa dan tangguh dengan do`a keras, usaha keras dan selalu berfikiran positif
A Business Model Analysis On Hj Nina’s Rental Housing Using Business Model Canvas Approach
No full textTangerang City has great potential for the growth of residential property projects. This region called thriving city due to economic growth which Tangerang City quite significantly from National. Terms of geographical, Tangerang City have access to strategic Jakarta so many transportation infrastructure could trigger growth property in the area. With the existence of business opportunities related to housing in Tangerang City, Mrs Hj Nina take advantage of these business opportunities by building land owned by property for a rented houses. But in running her business, Mrs Hj Nina has the main obstacle is competition around rented houses. One of the ways that Mrs Hj Nina’s rented house can explore the existing potential is by analyzing the right business model. Based on the results of the research on the identification of business model elements that exist in the house of Mrs Hj Nina, the author proposes several improvement programs for Mrs Hj Nina, namely expanding the house rent, develop business rented by diversifying business, adding facilities, doing community service, the owner having face to face meetings with rented houses, and house renters are active in the activities of local residents. With proposal the program for the improvement is expected to makes a business Mrs Hj Nina can develop and survived in the field of the business
VALIDATION FOR THE ABSOLUTE RADIOMETRIC CALIBRATION OF THE HJ-1B CCD SENSORS OF CHINA
No full textOn September 6, 2008, the satellite HJ-1B was launched into a sun-synchronous, near-polar orbit. In order to determine temporal changes of the absolute radiometric calibration of the HJ-1B satellite in flight, a program was carried out at DunHuang calibration field, Gansu province of China, from August 19 to 30, 2009. In this work, reflectance -based calibration method was employed to simulate the absolute calibration coefficients of the HJ-1B CCD sensors. Then the cotton field, cement court, water pool and test site was selected to validate the calibration coefficient. The validation results indicated that there had a good agreement between the imaged-based reflectance and the ground measurement of the type of cement court and test site. On the other hand, there had a disagreement of the type of cotton field and water because of the effect of mixed pixel.Geosciences, MultidisciplinaryRemote SensingEICPCI-S(ISTP)
Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4.
No full textItem does not contain fulltextThe chemokine receptor CXCR4 is a critical regulator of inflammation and immune surveillance, and it is specifically implicated in cancer metastasis and HIV-1 infection. On the basis of the observation that several of the known antagonists remarkably share a C(2) symmetry element, we constructed symmetric dimers with excellent antagonistic activity using a derivative of a cyclic pentapeptide as monomer. To optimize the binding affinity, we investigated the influence of the distance between the monomers and the pharmacophoric sites in the synthesized constructs. The affinity studies in combination with docking computations support a two-site binding model. In a final step, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was introduced as chelator for (radio-)metals, thus allowing to exploit these compounds as a new group of CXCR4-binding peptidic probes for molecular imaging and endoradiotherapeutic purposes. Both the DOTA conjugates and some of their corresponding metal complexes retain good CXCR4 affinity, and one (68)Ga labeled compound was studied as PET tracer
KERUGIAN YANG DIDERITA OLEH DOKTER AKIBAT PENGELOLAAN DANA BADAN PENYELENGGARA JAMINAN SOSIAL KESEHATAN DI RUMAH SAKIT UMUM DAERAH HJ. ANNA LASMANAH BANJARNEGARA
No full textResearch with the title Losses Suffered by Doctors due to the Management
of “Badan Penyelenggara Jaminan Sosial Kesehatan” in the Hj. Anna
Lasmanah Hospital Banjarnegara was used based on the statement of the Hj.
Anna Lasmanah Hospital’s Director in 2018, dr. Agung Budianto. Research that
have been done by the author in order to find out the truth of the data about the
loss that experienced by doctors using normative methods through interviews
between the author and Hj. Anna Lasmanah Hospital’s Director as well as
several representatives of doctors or dentists and this interview also involve the
Head of “BPJS Kesehatan” Banjarnegara field office. The result of this
research is the loss that experienced by the doctors is not material losses but
immaterial losses. This immaterial losses is the disappointment of the doctors
with “BPJS Kesehatan” who did the late payments which make the economic
needed of doctors not being able to get on time
MONITORING OF DEGRADING GRASSLAND BASED ON HJ-1A-HSI IMAGE
No full textGrassland is one of the most important parts of ecosystem on the earth. In China, one of the best grass lands is degrading because of draught or effects of human activity. It is important to monitor the growing condition of degrading grasslands. LAI is an important variable which can accurately represent the growing situation of grass. With DSD method, hyper-spectral images from HJ-1A satellite are used to inverse LAI accurately by restraining the effect of background. In this paper, multi spectral image was used to retrieve LAI with BRDF method for comparing. The maps of LAI and degradation level in study area were made. According to the results, the DSD method can retrieve LAI of grassland accurately and the HSI image of HJ-1A is a potential ideal data source for monitoring grassland.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345638900196&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Engineering, Electrical & ElectronicGeosciences, MultidisciplinaryRemote SensingCPCI-S(ISTP)
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