1,723,024 research outputs found
Dubai’s Artificial Intelligence Roadmap - The Journey so Far
Full text linkWesam Lootah Introduction By Tarek Saeed, Client Technical Advisor, IBM Middle East Dubai is at the forefront of adopting transformative technology and has already embarked on its journey to transform into an artificial intelligence (AI) enabled city. The journey started in October 2016 when Smart Dubai Government Establishment, Department of Economic Development and IBM collaborated to launch “Saad”, an AI-based government service powered by IBM’s AI capabilities. “Saad” is a service that ..
Discovery & Design of Novel DsbA Inhibitors Using Fragment-Based Design Strategies
No full textIn this work, Wesam designed and synthesised compounds to overcome multi-drug resistant bacteria and potentially protect future antibiotics from becoming obsolete. This was done by investigating a novel mechanism of disarming bacteria thereby making them unable to cause infections, rather than killing bacteria. The project focussed on using fragment-based drug design to develop inhibitors of a bacterial protein that is a master regulator of bacterial virulence
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Safety and efficacy of erythroxylum cuneatum / Wesam Radhi Kadhum
Full text linkErythroxylum cuneatum is a member of a tropical plant family which is considered to be a good source of phenolic compounds. The aims of this study were to determine the in vitro cytotoxicity, cytoprotective activity, genotoxicity and antioxidant enzymes specific activities of the standardized aqueous extract of E. cuneatum. In vitro toxicity of E. cuneatum extract in four cultured cell lines was determined. The IC50 values in the various cell lines were all higher than 100 µg/ml, indicating low cytotoxic effects. The cytoprotective activity was determined by treating four cultured cell lines (leukemia cells, colon cancer cells, liver cancer cells and normal liver cells) with hydrogen peroxide H2O2 (28-158 µM) and determining the effects of E. cuneatum (5-50 µg/ml) in the H2O2 treated cells. The results showed that H2O2 was cytotoxic to cells and the addition of E. cuneatum reduced its cytotoxicity. The cytoprotective activity was also determined by treating cultured cell lines (liver cancer cells and normal liver cells) with menadione (2methyl- l A-naphthoquinone) (12-30 µM) and determining the effects of the extract (5-50 µg/ml) in the menadione-treated cells. Results showed that the extract, was not able to rescue cells from the cytotoxicity effects of menadione. Genotoxicity of the extract in HepG2 and WRL68 cell lines were assessed by single cell gel electrophoresis (comet assay), whereby cells were treated with hydrogen peroxide (50 µM) as genotoxic control and different concentrations of E. cuneatum (0.005-1 mg/ml). A low level of DNA damage was seen at the highest concentration of 1 mg/ml while no DNA damage was seen at the other concentrations. E. cuneatum 50 µg/ml when incubated with normal and cancer liver cells significantly increased in catalase specific activity but did not affect cellular GPx and SOD activities. E. cuneatum standardized aqueous extract was found to be non cytotoxic and non genotoxic, showed protection to HepG2 and HCT116 cells from H2O2- induced toxicity but did alter menadione induced cell death. E. cuneatum (50 µg/ml) elevated catalase specific activity in HepG2 and WRL68 cells. More studies are needed if E. cuneatum is to be developed as a cytoprotectant
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Web-based data visualization and optimization methods for applications in urban planning
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014.Cataloged from PDF version of thesis.Includes bibliographical references (pages 95-96).This thesis deals with the problem of enhancing the understanding of urban information through interactive data-driven visualization and planning tools. In the first part of the thesis, I present a series of web-based data visualizations through maps to provide users with thorough understanding of their living environments, and highlight patterns and trends to raise their awareness of how cities evolve over time. In the second part, I focus on tools that support the planning of interventions on the urban level. Specifically, I tackle the problem of selecting the most optimal locations for placing new entities within the city using a modified k-means algorithm.by Wesam Manassra.M. Eng
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Autonomous vehicle path planning for persistence monitoring under uncertainty using Gaussian based Markov decision process
No full textOne of the main challenges facing online and offline path planners is the uncertainty in the magnitude and direction of the environmental energy because it is dynamic, changeable with time, and hard to forecast. This thesis develops an artificial intelligence for a mobile robot to learn from historical or forecasted data of environmental energy available in the area of interest which will help for a persistence monitoring under uncertainty using the developed algorithm
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