1,677 research outputs found
Effect of short-term smoking & L-arginine on coronary endothelial function assessed by cardiac magnetic resonance cold pressor testing: a pilot study
No full textBackground
The effect of smoking on coronary vasomotion has been investigated in the past with various imaging techniques in both short- and long-term smokers. Additionally, coronary vasomotion has been shown to be normalized in long-term smokers by L-Arginine acting as a substrate for NO synthase, revealing the coronary endothelium as the major site of abnormal vasomotor response. Aim of the prospective cohort study was to investigate coronary vasomotion of young healthy short-term smokers via magnetic resonance cold pressor test with and without the administration of L-Arginine and compare obtained results with the ones from nonsmokers.
Methods
Myocardial blood flow (MBF) was quantified with first-pass perfusion MRI on a 1.5 T scanner in healthy short-term smokers (N = 10, age: 25.0 ± 2.8 years, 5.0 ± 2.9 pack years) and nonsmokers (N = 10, age: 34.3 ± 13.6) both at rest and during cold pressor test (CPT). Smokers underwent an additional examination after administration of L-Arginine within a median of 7 days of the naïve examination.
Results
MBF at rest turned out to be 0.77 ± 0.30 (smokers with no L-Arginine; mean ± standard deviation), 0.66 ± 0.21 (smokers L-Arginine) and 0.84 ± 0.08 (nonsmokers). Values under CPT were 1.21 ± 0.42 (smokers no L-Arginine), 1.09 ± 0.35 (smokers L-Arginine) and 1.63 ± 0.33 (nonsmokers). In all groups, MBF was significantly increased under CPT compared to the corresponding rest examination (p < 0.05 in all cases). Additionally, MBF under CPT was significantly different between the smokers and the nonsmokers (p = 0.002). MBF at rest was significantly different between the smokers when L-Arginine was given and the nonsmokers (p = 0.035).
Conclusion
Short-term smokers showed a reduced response to cold both with and without the administration of L-Arginine. However, absolute MBF values under CPT were lower compared to nonsmokers independently of L-Arginine administration
Magnetic resonance cold pressor test to investigate potential endothelial dysfunction in patients suffering from type 1 diabetes
No full textBackground In its course, diabetes impairs microvascular function through endothelial dysfunction. As the response of myocardial perfusion to sympathetic stimulation through cold is modulated by endothelium‐related factors, an incipient endothelial dysfunction might be observed noninvasively by investigation of myocardial perfusion with a cold pressor test (CPT). This approach has been used in clinical MRI previously. Purpose To assess endothelial function of patients suffering from type 1 diabetes by MR CPT. Study Type Prospective cohort study. Subjects Twenty type 1 diabetics and 20 healthy volunteers. Field Strength/Sequence 3T, dynamic contrast enhanced perfusion (steady‐state free precession). Assessment Absolute quantitative myocardial perfusion values at rest and under CPT. Statistical Tests Kolmogorov–Smirnov test to determine normal distribution of the results. T ‐test for independent samples. Results Patients' mean myocardial perfusion was 0.68 cc/g/min at rest and 0.80 cc/g/min during CPT, respective values of 0.81 cc/g/min and 1.36 cc/g/min were found in healthy volunteers. Perfusion values differed significantly for CPT ( P < 0.01) but not for resting conditions ( P = 0.06). Data Conclusion This study demonstrated that endothelial function might be impaired in type 1 diabetes patients. This fosters the thesis that endothelial function may serve as an early biomarker for coronary artery disease in patients with type 1 diabetes while these patients are still clinically asymptomatic. Level of Evidence: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;48:1595–1601Siemens Healthcar
Opowiadanie kryminalne Anzelma Feuerbacha Andreas Bichel, Der M¨adchenschl¨achter
No full textAnzelm [Paul Johann Anselm] Feuerbach (1775–1833), the founder of the theory of psychological compulsion (Theorie des psychologischen Zwanges), was also famous as an author of criminal stories. In 1827 he published a book titled Aktenmäßige Darstellung merwürdigen Verbrechen, which contained more than 30 stories based on criminal cases involving manslaughter. One of these stories, with the original title Andreas Bichel, der Mädchenschlächter (Andreas Bichel, the slaughterer of girls), presents the history of a notorious murderer of young women. The motive of his acts was basically robbery. Law, especially legal proceedings, plays an important role in this story.Anzelm [Paul Johann Anselm] Feuerbach (1775–1833), the founder of the theory of psychological compulsion (Theorie des psychologischen Zwanges), was also famous as an author of criminal stories. In 1827 he published a book titled Aktenmäßige Darstellung merwürdigen Verbrechen, which contained more than 30 stories based on criminal cases involving manslaughter. One of these stories, with the original title Andreas Bichel, der Mädchenschlächter (Andreas Bichel, the slaughterer of girls), presents the history of a notorious murderer of young women. The motive of his acts was basically robbery. Law, especially legal proceedings, plays an important role in this story
Anzelm Feuerbach’s Criminal Story Andreas Bichel, der M¨adchenschl¨achter
No full textAnzelm [Paul Johann Anselm] Feuerbach (1775–1833), the founder of the theory of psychological compulsion (Theorie des psychologischen Zwanges), was also famous as an author of criminal stories. In 1827 he published a book titled Aktenmäßige Darstellung merwürdigen Verbrechen, which contained more than 30 stories based on criminal cases involving manslaughter. One of these stories, with the original title Andreas Bichel, der Mädchenschlächter (Andreas Bichel, the slaughterer of girls), presents the history of a noto- rious murderer of young women. The motive of his acts was basically robbery. Law, especially legal proceedings, plays an important role in this story
Dissertatio Politica De Nuptiis
No full textQuam ... in Celeberrima Witebergensium Academia Sub Praesidio ... Dni. M. Jacobi Rösers/ Sondershusa Schwartzburgici ... Publico & placido Eruditorum Examini submittit Author Andreas Mylius, Ileburgo Misnicus. In Audit. Minor. ad. d. 11. Iul. ...Druckvariante ohne Widmung, nicht identisch mit VD17 14:653394
Three-Dimensional Investigation of a 5 m Deflected Swale along the San Andreas Fault in the Carrizo Plain
No full textabstract: Topographic maps produced from Light Detection and Ranging (LiDAR) data are useful for paleoseismic and neotectonic research because they pro- vide submeter representation of faulting-related surface features. Offset measurements of geomorphic features, made in the field or on a remotely sensed imagery, commonly assume a straight or smooth (i.e., undeflected) pre-earthquake geometry. Here, we present results from investigation of an ∼20 cm deep and >5 m wide swale with a sharp bend along the San Andreas fault (SAF) at the Bidart fan site in the Carrizo Plain, California. From analysis of LiDAR topography images and field measure- ments, the swale was initially interpreted as a channel tectonically offset ∼4:7 m. Our observations from exposures in four backhoe excavations and 25 hand-dug trenchettes show that even though a sharp bend in the swale coincides with the trace of the A.D. 1857 fault rupture, the swale formed after the 1857 earthquake and was not tectonically offset. Subtle fractures observed within a surficial gravel unit overlying the 1857 rupture trace are similar to fractures previously documented at the Phelan fan and LY4 paleoseismic sites 3 and 35 km northwest of Bidart fan, respectively. Collectively, the fractures suggest that a post-1857 moderate-magnitude earthquake caused ground cracking in the Carrizo and Cholame stretches of the SAF. Our obser- vations emphasize the importance of excavation at key locations to validate remote and ground-based measurements, and we advocate more geomorphic characterization for each site if excavation is not possible
The teachings of Claudius Galen and Andreas Vesalius. comparative analysis
No full textThe article analyzes the teachings of Andreas Vesalius and Claudius Galen, their contribution to the development of medicine. The author shows not just a criticism of the teachings of Galen by Vesalius, but the progress that medicine has achieved over the centuries separating the two scientists.В статье дается анализ учений Андреаса Везалия и Клавдия Галена, их вклада в развитие медицины. Автор показывает не просто критику учений Галена Везалием, а тот прогресс, которого достигла медицина за столетия, разделяющие двух ученых
Linguocultural features of the novel Volga, Volga and The Beautiful Women by Russian-German writer Andreas Keller
No full textThe article is dedicated to the novel «Volga, Vodka and the Beautiful Women» (2011) by the Russian-German author Andreas Keller. Some fundamental problems of sociolinguistics and cultural studies are examined. The research deals with the problems of self-identity, the interaction between two different cultures, as well as the questions of cooperation between the author and the publisher in the context of the editorial preparation of the novel on the Russian-German topic.Der Artikel widmet sich dem Roman «Wolga, Wodka und die schönen Frauen» (2011) vom russlanddeutschen Autor Andreas Keller. Es werden am Beispiel der Romanedition einige grundlegende Probleme der Soziolinguistik und Kulturwissenschaft betrachtet. Die Forschung beschäftigt sich mit den Problemen der Selbstidentität, der Interaktion zwischen zwei verschiedenen Kulturen, sowie mit den Fragen der Zusammenarbeit zwischen dem Autor und dem Verlag im Rahmen der editorischen Erstellung des Romans zum russisch-deutschen Thema
Porous Becomings:Anthropological Engagements with Michel Serres
No full textOne of the foremost intellectuals of his generation, French philosopher of science Michel Serres (1930–2019) broke free from disciplinary dogmas. His reflections on science, culture, technology, art, and religion have proved foundational to scholars across the humanities. The contributors to Porous Becomings bring the inspirational and enigmatic world of Serres to the attention of anthropology. Through ethnographic encounters as diverse as angels and religious conversion in Ethiopia, the percolation of war in Bosnia, and incarcerated bodies crossing the Atlantic, the contributors showcase how Serres’s interrogation of the fundamentals of human existence opens new pathways for anthropological knowledge. Proposing the notion of "porosity" to characterize permeability across boundaries of time, space, literary genre, and academic discipline, they draw on Serres to map the constellations that connect humans, time, technology, and planet Earth. The volume concludes with a conversation between the editors and Vibrant Matter author Jane Bennett.Contributors. Andreas Bandak, Jane Bennett, Tom Boylston, Steven D. Brown, Matei Candea, Alberto Corsín Jiménez, David Henig, Michael Jackson, Daniel M. Knight, Celia Lowe, Morten Nielsen, Stavroula Pipyrou, Elizabeth Povinelli, Andrew Shryock, Arpad Szakolcza
It's the market power, stupid! Stock return patterns in international bank M&A
No full textThis paper analyzes capital market reactions to international bank M&A. We investigate combined stock return patterns of targets, bidders, and their peers upon takeover announcement, and closing or withdrawal. We distinguish five common M&A hypotheses and relate characteristic and mutually exclusive abnormal stock return patterns to each hypothesis. We find that investors believe in gains through the exploitation of market power by the post-merger entity. In a multinomial logistic model we show that patterns related to market power significantly concur with large relative target size, intra-industry mergers, and increasing market concentration, suggesting a substantial lessening of competition through M&A. --M&A,Banks,Event Study,Peer Returns,Market Power
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