1,720,966 research outputs found
Quality of life after low-dose rate-brachytherapy for prostate carcinoma – long-term results and literature review on QLQ-C30 and QLQ-PR25 results in published brachytherapy series
No full textAbstract Background Patient-reported health-related quality of life (HRQOL) differs between treatment options for prostate carcinoma. Long-term HRQOL data in brachytherapy series are scarce. Therefore, we analyzed prostate-specific and general HRQOL in patients treated with brachytherapy for prostate carcinoma after long-term follow-up. Methods Two hundred ninety-six patients with prostate carcinoma were treated with brachytherapy (01/1998–11/2003). General and prostate-specific HRQOL were measured using EORTC-QLQ-C30 and EORTC-QLQ-PR25, respectively. Patients were asked to complete the questionnaires after a median follow-up of 141 (119–181) months. QLQ-C30 results were compared to the German reference population. QLQ-PR25 results were compared to an earlier follow-up after a median of 51 months (no published QLQ-PR25 reference population for comparison). Additionally, a literature review on HRQOL data in brachytherapy series was performed. Results One hundred six (35.8%) patients were lost to follow-up, 70 (23.6%) had died. 120 (40.5%) patients were contacted. 80 questionnaires were returned (27% of the original cohort; 91% of alive patients were ≥70 years). Sexual activity declined over time (mean scores: 40.5 vs. 45.5; p = 0.006), hormonal treatment-related symptoms, problems associated with incontinence aids, and burden of obstructive urinary symptoms did not differ significantly compared to the 51-month follow-up. General HRQOL was numerically better in our cohort as compared to the German reference population (> 16% relative difference for both age strata; < 70 and ≥70 years). Conclusions Our results indicate that symptom-burden after long-term follow-up and associated prostate-specific HRQOL remains relatively stable from 51 to 141 months. General HRQOL in surviving patients was numerically better compared to the reference population
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Akute kognitive Veränderungen unter zerebraler Strahlentherapie bei erwachsenen Tumorpatienten
Get PDFKognitive Einschränkungen bei Tumorpatienten im Erwachsenenalter stellen ein häufiges Problem dar. Vorhandene Studien zu diesem Thema fokussieren meist auf die Spät- und Langzeiteffekte von Chemo- oder zerebraler Strahlentherapie. Akute Therapieeffekte stehen nur selten im Forschungsfokus. Vor diesem Hintergrund war es das Ziel der vorliegenden Arbeit, Ausmaß, Verlauf und potentielle Risikofaktoren kognitiver Veränderungen in der akuten Phase der Strahlenreaktion zu untersuchen. Für die Studie wurden erwachsene Tumorpatienten, die eine zerebrale Radiochirurgie, Teilhirn- oder Ganzhirnbestrahlung erhalten sollten (n=150), mit zwei Kontrollgruppen (n=21 alleinig extrakraniell bestrahlte Patienten und n=22 kombiniert radiochemotherapierte Patienten) prospektiv vor Beginn der Radiotherapieserie, an den ersten 1 bis 3 Behandlungstagen und zum Abschluß der Radiotherapieserie verglichen. Mit standardisierten, international etablierten, reliablen und validen Testverfahren wurden die Bereiche Gedächtnis, visuell-räumliche Konstruktion und Aufmerksamkeit untersucht. Zusätzlich wurden das prämorbide Intelligenzniveau und das psychische Allgemeinbefinden der Patienten sowie weitere potentielle Determinanten für das Auftreten kognitiver Veränderungen kontrolliert und explorativ analysiert. Die Ergebnisse geben Hinweise darauf, daß subtile kognitive Veränderungen bei Patienten, die eine Bestrahlung des Gehirns erhalten, in der akuten Phase der Strahlenreaktion auftreten, auch wenn die Patienten unter einem klinischen Blick kognitiv weitgehend unverändert erscheinen. Hauptrisikofaktor für eine kognitive Verschlechterung unter Bestrahlung scheint ein hohes kognitives Leistungsniveau vor Bestrahlungsbeginn zu sein. Als weitere potentielle Risikofaktoren können ein zerebraler Befall, die Ganzhirnbestrahlung und infratentorielle Strukturen im Bestrahlungsvolumen identifiziert werden
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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