2,291 research outputs found
Ask questions, get sales : close the deak and create long-term relationships / Stephan Schiffman.
No full textIncludes index.v, 168 pages ;In Ask Questions, Get Sales, the author and sales guru Stephan Schiffman helps readers boost their careers to the gold-medal level by teaching them how to strengthen their questioning skills during the sales process. The premise is simple yet effective: In order to be successful, salespeople need to change their mindset from "need-orientated" to "do-orientated". The message of the book centers around six core "do" questions: What do you do? How do you do it? When and where do you do it? Why do you do it that way? Who do you do it with? How can we help you do it better? With this indispensable guide in their briefcase, salespeople will have information at the ready to score big sales over the short term and the long term
Kultur. Theorien der Gegenwart. 2. erweiterte und aktualisierte Auflage, VS, Wiesbaden 2011 (Moebius, Stephan, u. Quadflieg, Dirk (Hrsg.))
No full textKultur. Theorien der Gegenwart. 2. erweiterte und aktualisierte Auflage, VS, Wiesbaden 2011 (Moebius, Stephan, u. Quadflieg, Dirk (Hrsg.))
No full textUnemployment Benefits and Unemployment Rates of Low-Skilled and Elder Workers in West Germany: A Search Equilibrium Approach
No full textApproach Author & abstract Download 16 References 1 Citations Related works & more Corrections Author Listed: Launov, Andrey ([email protected]) (University of Kent) Wolff, Joachim ([email protected]) (Institute for Employment Research (IAB), Nuremberg) Klasen, Stephan ([email protected]) (University of Göttingen) Registered: Stephan Klasen Abstract In this paper we investigate whether the extension of the entitlement to unemployment benefits in the mid 80s can explain the increase in the unemployment rates of unskilled and elder workers in western Germany. To answer this question we estimate a version of the Burdett-Mortensen search equilibrium model and analyze how workers’ search behaviour responded to these reforms. We try both nonparametric and fully-parametric estimation methods and identify the cases in which the nonparametric approach cannot be applied. We find that the entitlement reforms are largely responsible for the increase of unemployment among unskilled workers
Unemployment Benefits and Unemployment Rates of Low-Skilled and Elder Workers in West Germany: A Search Equilibrium Approach
No full textApproach Author & abstract Download 16 References 1 Citations Related works & more Corrections Author Listed: Launov, Andrey ([email protected]) (University of Kent) Wolff, Joachim ([email protected]) (Institute for Employment Research (IAB), Nuremberg) Klasen, Stephan ([email protected]) (University of Göttingen) Registered: Stephan Klasen Abstract In this paper we investigate whether the extension of the entitlement to unemployment benefits in the mid 80s can explain the increase in the unemployment rates of unskilled and elder workers in western Germany. To answer this question we estimate a version of the Burdett-Mortensen search equilibrium model and analyze how workers’ search behaviour responded to these reforms. We try both nonparametric and fully-parametric estimation methods and identify the cases in which the nonparametric approach cannot be applied. We find that the entitlement reforms are largely responsible for the increase of unemployment among unskilled workers
Measuring Vulnerability to Poverty Using Long-Term Panel Data
No full textMeasuring Vulnerability to Poverty Using Long-Term Panel Data Author & abstract Download & other version 16 References 4 Citations Related works & more Corrections Author Listed: Katja Landau (Georg-August-University Göttingen) Stephan Klasen (Georg-August-University Göttingen) Walter Zucchini (Georg-August-University Göttingen) Registered: Stephan Klasen Abstract We investigate the accuracy of ex ante assessments of vulnerability to income poverty using cross-sectional data and panel data. We use long-term panel data from Germany and apply di fferent regression models, based on household covariates and previous-year equivalence income, to classify a household as vulnerable or not. Predictive performance is assessed using the Receiver Operating Characteristics (ROC), which takes account of false positive as well as true positive rates. Estimates based on cross-sectional data are much less accurate than those based on panel data, but for Germany, the accuracy of vulnerability predictions is limited even when panel data are used. In part this low accuracy is due to low poverty incidence and high mobility in and out of poverty
Measuring Vulnerability to Poverty Using Long-Term Panel Data
No full textMeasuring Vulnerability to Poverty Using Long-Term Panel Data Author & abstract Download & other version 16 References 4 Citations Related works & more Corrections Author Listed: Katja Landau (Georg-August-University Göttingen) Stephan Klasen (Georg-August-University Göttingen) Walter Zucchini (Georg-August-University Göttingen) Registered: Stephan Klasen Abstract We investigate the accuracy of ex ante assessments of vulnerability to income poverty using cross-sectional data and panel data. We use long-term panel data from Germany and apply di fferent regression models, based on household covariates and previous-year equivalence income, to classify a household as vulnerable or not. Predictive performance is assessed using the Receiver Operating Characteristics (ROC), which takes account of false positive as well as true positive rates. Estimates based on cross-sectional data are much less accurate than those based on panel data, but for Germany, the accuracy of vulnerability predictions is limited even when panel data are used. In part this low accuracy is due to low poverty incidence and high mobility in and out of poverty
Evaluation of in-store processes related to returnable packaging services offered in grocery stores - the store management perspective
No full textAuthor Stephan LehnerMasterarbeit Universität Linz 202
Evaluation of in-store processes related to returnable packaging services offered in grocery stores - the store management perspective
No full textAuthor Stephan LehnerMasterarbeit Universität Linz 202
Transcriptome profiling identifies disease- and therapy-associated signatures in atopic dermatitis
No full textAtopic dermatitis (AD) is the most common chronic inflammatory skin disease and has a substantially detrimental impact on patients and caregivers. The disease is characterised by eczematous lesions, persistent itch, and a relapsing and remitting pattern, and a high heterogeneity with currently unpredictable disease courses and clinical outcomes. AD potentially comprises a variety of endotypes, which share common clinical characteristics, but arise from distinct molecular and cellular mechanisms. Although omics analyses have promoted the understanding of disease mechanisms and the development of innovative targeted therapies, many questions regarding the pathophysiology, disease heterogeneity, and patient-stratified therapeutic approaches remain unresolved. So far, most of the transcriptome studies, i.e. studies investigating the gene expression, on AD relied on microarray data, were conducted in the context of clinical trials, examined one timepoint only, and rarely included healthy control subjects as reference. Further, most of the previous transcriptome studies in AD were focused exclusively on the skin, while blood was not covered, although there is robust evidence for systemic immune abnormalities in AD. Within the scope of this work, I analysed transcriptome data generated from longitudinal skin and blood samples of deeply characterised AD patients from the TREATgermany registry as well as of healthy controls using sensitive and unbiased mRNA sequencing. In a first study, I was able to identify a stable core transcriptome signature in both lesional and nonlesional skin differentiating patients from healthy individuals and reflecting epidermal barrier dysfunction, innate immune activation and heightened itch signalling as key disease mechanism. A second dynamic signature reflects a progressive activation of immune responses with heightened inflammation in lesions. A large proportion of transcriptomic dysregulation is reverted with clinically successful systemic treatment with, however, a considerable residual genomic profile with treatment-specific differences indicating insufficient disease control on the molecular level that might give rise to flares and recurrences. In a second study, I characterised skin transcriptomic signatures attributable to natural killer (NK) cells, which recently have been suggested to be involved in the pathophysiology of AD. The analysis showed that NK cells and related killer cells accumulate in AD lesions, and that there is a disturbed composition of resting and activated NK cells. After successful remission through systemic treatment I observed qualitative albeit not quantitative shifts of NK cell signatures. In a third work, I analysed whole-blood transcriptome data of patients with AD and healthy controls. In a cluster analysis, I identified two potential endotypes, one of which showed a high degree of systemic transcriptomic dysregulation and an eosinophilic profile, and another showing a low degree of dysregulation and a non-eosinophilic profile. Association of eosinophil expression profiles with disease activity suggest that these endotypes might have clinical implications. Detected signatures related to NK cells indicate a reduced abundance and dysfunction of certain NK cells subsets also in the peripheral blood, underpinning the importance of this cell type for the pathophysiology of AD
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