6,968 research outputs found
Interview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American City
No full textInterview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American Cit
Resurrecting the Author
No full textPresentation of Nicholas Wolterstorff\u27s Paper Resurrecting the Author with time after for questions beginning at 18:00
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
No full textAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
The role of TcdB and TccC subunits in secretion of the photorhabdus Tcd toxin complex
No full textThe Toxin Complex (TC) is a large multi-subunit toxin encoded by a range of bacterial pathogens. The best-characterized examples are from the insect pathogens Photorhabdus, Xenorhabdus and Yersinia. They consist of three large protein subunits, designated A, B and C that assemble in a 5:1:1 stoichiometry. Oral toxicity to a range of insects means that some have the potential to be developed as pest control technology. The three subunit proteins do not encode any recognisable export sequences and as such little progress has been made in understanding their secretion. We have developed heterologous TC production and secretion models in E. coli and used them to ascribe functions to different domains of the crucial B+C sub-complex. We have determined that the B and C subunits use a secretion mechanism that is either encoded by the proteins themselves or employ an as yet undefined system common to laboratory strains of E. coli. We demonstrate that both the N-terminal domains of the B and C subunits are required for secretion of the whole complex. We propose a model whereby the N-terminus of the C-subunit toxin exports the B+C sub-complex across the inner membrane while that of the B-subunit allows passage across the outer membrane. We also demonstrate that even in the absence of the B-subunit, that the C-subunit can also facilitate secretion of the larger A-subunit. The recognition of this novel export system is likely to be of importance to future protein secretion studies. Finally, the identification of homologues of B and C subunits in diverse bacterial pathogens, including Burkholderia and Pseudomonas, suggests that these toxins are likely to be important in a range of different hosts, including man
Nicholas de Monchaux: Local Code / Real Estates
No full textNicholas de Monchaux is an architect and urbanist whose work explores the intersections between nature, technology, and the city. He is the author of Spacesuit: Fashioning Apollo (MIT Press, 2011), an architectural history of the Apollo 11 spacesuit. He is Assistant Professor of Architecture and Urban Design at UC Berkeley. The work of his design studio has been exhibited widely and is currently being featured in the US Pavillion of the 13th Venice Biennale
Nicholas Meyer: 10-31-1979
No full textNicholas Meyer is a screenwriter, producer, director, and author, and a graduate of the University of Iowa. He is the author of the screenplay the Seven Per Cent Solution and co-author of The Black Orchid. He begins the interview by discussing his professional career as both a film writer/director and a novelist. He then talks about how he began writing novels, and discusses the research that goes into his novels. Meyer continues by discussing his movie Time After Time and concludes the interview by listing prominent teachers and writing influences.Archived web contentSUNY BrockportWriters Forum Video
Nicholas Meyer: 10-31-1979
No full textNicholas Meyer is a screenwriter, producer, director, and author, and a graduate of the University of Iowa. He is the author of the screenplay the Seven Per Cent Solution and co-author of The Black Orchid. He begins the interview by discussing his professional career as both a film writer/director and a novelist. He then talks about how he began writing novels, and discusses the research that goes into his novels. Meyer continues by discussing his movie Time After Time and concludes the interview by listing prominent teachers and writing influences.https://digitalcommons.brockport.edu/writers_videos/1022/thumbnail.jp
Interview with Nicholas Wade by Marni Siegel, November 8, 2007
No full textThe interview was a project of the Center for Public Genomics (http://www.genome.duke.edu/centers/cpg/).Nicholas Wade is a science writer for the New York Times and author of several books, including LifeScripts, about genetics and genomics. He also covered the Asilomar Conference for Science magazine.Funded by a grant from the National Human Genome Research Institute and the US Department of Energy (P50 HG003391)
LSE festival Beveridge 2.0 preview: the five giants by Nicholas Timmins
No full textOn Monday 19 February, LSE Festival opened with ‘The Five Giants and the Ministers Who Made a Difference’. Chaired by LSE Director Minouche Shafik, Nicholas Timmins, author of The Five Giants: A Biography of the Welfare State, and Professor Sir Julian Le Grand debated the key UK politicians who really made a difference when it came to Beveridge’s ‘Five Giants’: listen to the podcast here. Ahead of the event, Nicholas Timmins gives insight into the reception and impact of Beveridge’s 1942 report, as well as its enduring significance in today’s global, 21st-century context
01-06-2020 Author Nicholas Sparks Speaking at SWOSU on February 5
No full textAuthor Nicholas Sparks speaks at Southwestern Oklahoma State University in Weatherford on Wednesday, February 5, and the public is invited
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