1,355,256 research outputs found

    Washbrook, William Leigh

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    William Washbrook Jr. was born on May 12, 1922 in Lethbridge, Alberta to parents William and Gladys Washbrook. He was raised and educated in the city with brothers, Edwin and Herbert and sister, Beverley. William enjoyed swimming, hockey and football. At time of enlistment, he was single and employed as a mechanic for Trans-Canada Airlines. On June 22, 1942, William Washbrook enlisted for service in the Royal Canadian Air Force. He spent the next fifteen months training at bases in Canada and in August 1943, he qualified as an air gunner. Pilot Officer Washbrook arrived in the United Kingdom on September 9, 1943. After six months of further training in the United Kingdom, he was posted to 215 Squadron Royal Air Force in India for service in the Burma Theatre. On January 3, 1945, Pilot Officer Washbrook was part of a Liberator crew deployed to attack an enemy position in Burma. As they approached their target, the aircraft was hit by enemy fire and plummeted to the ground. The incident was witnessed by other members of his squadron, and they noted that none of the crew bailed out of the craft and all of the men were presumed to be dead. As his remains were never recovered or identified, Pilot Officer Washbrook is remembered on the Singapore Memorial. For his wartime service, he was awarded the 1939-45 Star, Burma Star, Defence Medal, War Medal and Canadian Volunteer Service Medal with Clasp. His mother, Gladys received a Memorial Cross in honour of her son

    Comparison of antiparallel A-AT and T-AT triplets within an alternate strand DNA triple helix

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    We have examined the formation of alternate strand triple-helices at the target sequence A11(TC)6-(GA)6T11 using the oligonucleotides T11(AG)6 and T11(TG)6, by DNase I footprinting. These third strands were designed so as to form parallel T-AT triplets together with antiparallel G-GC and A-AT or T-AT triplets. We find that, although both oligonucleotides yield clear footprints at similar concentrations (0.3 μM) in the presence of manganese, only T11(TG)6 forms a stable complex in magnesium-containing buffers, albeit at a higher concentration (10-30 μM). Examination of the interaction of (AG)6 and (TG)6 with half the target site confirmed that the complex containing A-AT triplets was only stable in the presence of manganese. In contrast no binding of (TG)6 was detected in the presence of either metal ion, suggesting that the reverse-Hoogsteen T-AT triplet is less stable that GGC. We suggest that, within the context of GGC triplets, the rank order of antiparallel triplet stability is A·AT(Mn2+) &gt; T.AT(Mn2+) &gt; T.AT (Mg2+) &gt; A.AT (Mg2+). Third strands containing a single base substitution in the centre of either the parallel or antiparallel portion showed a (10-fold) weaker interaction in manganese-containing buffers, and no interaction in the presence of magnesium.</p

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Alternate-strand DNA triple-helix formation using short acridine-linked oligonucleotides

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    We have used DNAase I footprinting to examine the formation of intermolecular DNA triple helices at sequences containing adjacent blocks of purines and pyrimidines. The target sites G6T6·A6C6 and T6G6·C6A6 were cloned into longer DNA fragments and used as substrates for DNAase I footprinting, which examined the binding of the acridine (Acr)-linked oligonucleotides Acr-T5G5 and Acr-G5T5 respectively. These third strands were designed to incorporate both G·GC triplets, with antiparallel G(n) strands held together by reverse Hoogsteen base pairs, and T·AT triplets, with the two T-containing strands arranged antiparallel to each other. We find that Acr-T5G5 binds to the target sequence G6T6·A6C6, in the presence of magnesium at pH 7.0, generating clear DNAase I footprints. In this structure the central guanine is not recognized by the third strand and is accessible to modification by dimethyl sulphate. Under these conditions no footprint was observed with Acr-G5T5 and T6G6·C6A6, though this triplex was evident in the presence of manganese chloride. Manganese also facilitated the binding of Acr-T5G5to a second site in the fragment containing the sequence T6G6·C6A6. This represents interaction with the sequence G4ATCT6, located at the boundary between the synthetic insert and the remainder of the fragment, and suggests that this bivalent metal ion may stabilize triplexes that contain one or two mismatches. Manganese did not affect the interaction of either oligonucleotide with G6T6·A6C6.</p

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author, publisher and bookseller : a tripartite synergy in Nigerian book industry

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    This work is about the roles of Author, Publisher and Bookseller in Book development in Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after which it proceeded by defining who an author, a publisher, and a bookseller is and expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in the emerging Information Society. Furthermore, the various constraints to book development were identified while the paper advised on how the Book Industry can be further promoted in Nigeria. However, the paper concluded and made recommendations on how the Book sector can help in enhancing scholarship in the country
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