7,330 research outputs found
Comparative Study for Safety and Efficacy of OAGB and SADJB-SG: A Retrospective Study
Full text linkMingyue Shang,* Zhehong Li,* Dexiao Du,* Guangzhong Xu, Dongbo Lian, Zhaohui Liao, Dezhong Wang, Buhe Amin, Zheng Wang, Weijian Chen, Nengwei Zhang, Liang Wang Surgery Centre of Diabetes Mellitus, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nengwei Zhang; Liang Wang, Surgery Centre of Diabetes Mellitus, Capital Medical University Affiliated Beijing Shijitan Hospital, No. 10, Tieyi Road, Yangfangdian, Haidian District, Beijing, 100038, People’s Republic of China, Tel +8613801068802 ; +8619800320171, Email [email protected]; [email protected]: Obesity and related complications are managed by One Anastomosis Gastric Bypass (OAGB) and Single Anastomosis Duodeno-Jejunal Bypass with Sleeve Gastrectomy (SADJB-SG), both of which are adapted from traditional gastric bypass procedures. However, there are no current comparative studies on the safety and efficacy of these two surgical procedures.Patients and Methods: Preoperative baseline data of patients who had undergone OAGB and SADJB-SG surgeries from June 2019 to June 2021 were retrospectively analyzed at our bariatric facility. Postoperative data, including weight changes, improvement in type 2 diabetes (T2DM), and complication rates were collected over 2 years. This was followed by a comprehensive evaluation of the safety and efficacy of the two surgical procedures.Results: A total of 63 patients completed the follow-up in this study. At the 24-month follow-up, excess weight loss percentage (EWL%) for the OAGB and SADJB-SG was 73.970± 5.005 and 75.652± 7.953, respectively (P-value = 0.310); total weight loss percentage (TWL%) was 24.006± 8.231 and 23.171± 6.600, respectively (P-value = 0.665). The diabetes remission rates for the two groups were 71.429% and 69.048%, respectively (P-value = 0.846). The cost for OAGB was 55088.208± 1508.220 yuan, which was significantly lower than the 57538.195± 1374.994 yuan for SADJB-SG (P-value< 0.001).Conclusion: The two surgical procedures are reliable in terms of safety and efficacy, and each has distinct advantages. While OAGB has reduced operational expenses, SADJB-SG offers a broader range of applicability.Keywords: one anastomosis gastric bypass, single anastomosis duodeno-jejunal bypass with sleeve gastrectomy, safety, efficac
A Liveness-Enforcing Supervisor Tolerant to Sensor-Reading Modification Attacks
No full textIn cyber-physical systems (CPSs), it is of great importance to handle network attack issues. In this article, we consider the supervisory control layer of CPSs, focusing on closed-loop control systems vulnerable to sensor-reading modification attacks (SM-attacks), which may disguise the occurrence of an event as a different event by modifying appropriately sensor readings in sensor communication channels. In particular, we consider the plant modeled as a bounded Petri net and the control specification consisting in liveness enforcing. Based on repeatedly computing a more restrictive liveness-enforcing supervisor under no attack and constructing a so-called basic supervisor, a method that synthesizes a liveness-enforcing supervisor tolerant to an SM-attack is proposed
Stabilizing Quantum States by Constructive Design of Open Quantum Dynamics
Full text linkBased on recent work on the asymptotic behavior of controlled quantum Markovian dynamics, we show that any generic quantum state can be stabilized by devising constructively a simple Lindblad-GKS generator that can achieve global asymptotic stability at the desired state. The applicability of such result is demonstrated by designing a direct feedback strategy that achieves global stabilization of a qubit state encoded in a noise-protected subspace
Kajian bangunan lama : Masjid Sg. Ramal Luar, Kajang / Abdul Aziz Ramli ... [et al.]
Full text linkMesjid Sg. Ramal Luar, Kajang, Selangor, telah dibina pada Tahun 1929. Dengan harga sebanyak $40,000/-, wang ini datangnya dari seorang bijakpandai iaitu Pegawai Daerah yang bernama Datuk Abu Samah. Beliau telah beriktiar supaya penduduk-penduduk kampung yang kebanyakannya penoreh getah mengenepikan sejumlah wang, dari kupon getah mereka dikumpul dan dari sedekah jahriah orang ramai
Fine-Tuning Mesochannel Orientation of Organically Functionalized Mesoporous Silica Nanoparticles
No full textSupervisory Control of Petri Nets in the Presence of Replacement Attacks
No full textThis article addresses the robust control problem of discrete event systems assuming that replacement attacks may occur, thus making it appear that an event that has occurred looks like another event. In particular, we assume that this is done by tampering with the sensor-readings in the sensor communication channel. Specifically, we use Petri nets as the reference formalism to model the plant and assume a control specification in terms of a generalized mutual exclusion constraint. We propose three different methods to derive a control policy that is robust to the possible replacement attacks. The first two methods lead to an optimal (i.e., maximally permissive) policy but are computationally inefficient when applied to large-size systems. On the contrary, the third method computes a policy more efficiently and reveals more easily implementable in practice. However, this is done at the expense of optimality
Comparison of δ-SG-283Q and δ-SG-283R on the interaction to other five DGC components.
No full text<p>Fig 5<i>A</i> compares IP and Co-IP results between δ-SG-283Q and δ-SG-283R. In HEK293T cells, full-length δ-SG-283Q or δ-SG-283R was separately co-expressed with full-length α-SG, β-SG, γ-SG, α-DG, and β-DG. Then the cell were harvested and checked by WB for expression of each protein (<i>a</i>, <i>b</i>), IP (<i>c</i>), and Co-IP (<i>d</i>). A statistic summary of arbitrary unit of density (AUD) from 4 independent assays was shown (<i>d</i>). Fig 5<i>B</i> compares pull-down results between GST-δ-SG-CT-283Q and GST-δ-SG-CT-283R. 10% <sup>35</sup>S-methionine-labeled protein input of α-SG-NT, β-SG-CT, γ-SG-CT, α-DG-FL, and β-DG-CT shown by autoradiography (<i>a</i>) and 33% protein input of GST, GST-δ-SG-CT-283Q, and GST-δ-SG-CT-283R shown by CBB staining (<i>b</i>) were used in the pull-down assay (<i>c</i>). The bound α-SG, β-SG, γ-SG, α-DG, and β-DG to GST-δ-SG-CT-283Q or to GST-δ-SG-CT-283R was compared by WB (<i>c</i>) with a statistic summary of AUD from 4 independent pull-down assays (<i>d</i>).</p
Experimental investigation of the temperature effect on the structural response of SG-laminated reinforced glass beams
No full textTo generate high-level redundancy for structural glass beams, a novel concept of laminating a metal reinforcement to a structural glass beam has been developed at Delft University of Technology (TU Delft). This concept makes use of the relatively stiff polymer interlayer material SentryGlas (SG) to bond the metal to the glass. However, due to the visco-elastic properties of the SG, its stiffness varies at different temperature levels. To what extent this temperature dependency has an effect on the structural response of the beam composite has been experimentally investigated in cooperation with Ghent University (UGent) and is the subject of current publication. Two separate series of pull-out tests, to investigate the bond strength, and beam tests, to investigate the post-breakage response, have been conducted at -20, 23 and 60 degrees C. The pull-out tests revealed a high temperature dependency of the bond strength of SG. This temperature dependency also had an effect on the structural response of the beams. However, regardless of temperature level all beams showed high-level plastic response and high redundancy. It is therefore concluded that temperature levels of -20 to 60 degrees C do not endanger the structural safety of SG-laminated reinforced glass beams.RESSLA
Effect of δ-SG-283R on Localization of β/δ/γ-SG to the Plasma Membrane Surface.
No full text<p>Fig 6<i>A</i> compares cell surface biotinylation assay results between δ-SG-283Q and δ-SG-283R. In HEK293T cells, full-length δ-SG-283Q or δ-SG-283R was separately co-expressed with full-length β-SG and γ-SG. The amount of transfected sarcoglycans targeted to the cell surface was determined by labeling cells with membrane-impermeable NHS-LC-biotin. Biotinylated proteins were isolated with avidin and identified by WB. The specificity of cell surface biotinylation was demonstrated by the absence of cytoplasmic HSP70 in the avidin-bound fraction. In each lane, 10 μg protein was loaded. Fig 6<i>B</i> shows a statistic summary from 5 independent assays. *: <i>p</i><0.05 <i>vs</i> δ-SG-283R.</p
Blocking TLR-TICAM-1 pathway by RSV sG
Full text linkMonocyte-derived dendritic cells (mDCs) recognize viral RNA extrinsically by TLR3 on the membrane and intrinsically RIG-I/MDA5 in the cytoplasm to induce type I interferons (IFNs) and mDC maturation. When mDCs were treated with live or UV-irradiated respiratory syncytial virus (RSV), early (~4 h) induction of IFN-β detected in other virus infections was barely observed. Live RSV subsequently replicated to activate the cytoplasmic IFN-inducing pathway leading to robust type I IFN induction. We found that RSV initial attachment to cells blocked polyI:C-mediated IFN-β induction, and this early IFN-β-modulating event was abrogated by Abs against envelope proteins of RSV, demonstrating the presence of a IFN-regulatory mode by early RSV attachment to host cells. By IFN-stimulated response element (ISRE) reporter analysis in HEK293 cells, polyI:C- or LPS-mediated ISRE activation was dose-dependently inhibited by live and inactive RSV to a similar extent. Of the RSV envelope proteins, simultaneously-expressed or exogenously-added RSV G or soluble G (sG) proteins inhibited TLR3/4-mediated ISRE activation in HEK293 cells. sG proteins expressed in cells did not affect the RIG-I/MDA5 pathway but inhibited the TLR adaptor TRIF/TICAM-1 pathway for ISRE activation. Finally, extrinsically-added sG protein suppressed the production of IFN-β in mDCs. Although the molecular mechanism of this extrinsic functional mode of the RSV G protein remains undetermined, G proteins may neutralize the F protein function that promotes IFN-mediated mDC modulation via TLR4 and may cause insufficient raising cell-mediated immunity against RSV
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