156,925 research outputs found
Agnes Wan, piano, [Sept. 25, 2009]
No full textAgnes Wan, pianoRecorded Sept. 25, 2009, in Ingram Hall, Vanderbilt University, Nashville, Tenn.Sonata in E, K. 531 ; Sonata in A, K. 113 / Domenico Scarlatti -- Arabesque, op. 18 / Robert Schumann -- Toccata in E minor, BWV 914 / Johann Sebastian Bach -- The seasons. September : The hunt ; October : Autumn song / Pyotr Tchaikovsky -- [Intermission] -- French suite no. 5 in G, BWV 816 / Johann Sebastian Bach -- Three Chinese paintings for solo piano / Pui-Shan Cheung -- Sonata in A, D. 664 / Franz Schubert -- [Encores]Blair School of Musi
Wan et al, PLOS ONE 2017 (PONE-D-16-40897)
No full textThe data set accompanies the article titled: “Morphology Analysis of Human Umbilical Vein Endothelial Cells Co-cultured with Ovarian Cancer Cells in 3D for Oncogenic Angiogenesis Assay” PLoS ONE (2017) and includes:
- Raw images before any processing;
- Raw viaiblity data for drug testing (Cisplatin & Paclitaxel)
How: The pictures are in JEPG format, so any figure reading software can open them; The spreadsheets were made in Office Excel.
Why: The publisher (PLOS ONE) requires the raw data to be accessible for the paper publication.
When: the data were created 2016-201
Wan Kyu Chung's Graduate Recital
No full textOriginal Format: CassetteComposers in the first graduate recital: Ludwig van Beethoven; Claude Debussy; Sergei ProkofieffComposers in the second graduate recital: W. A. Mozart; D. Scarlatti; F. SchubertFirst Recital: PianoSecond Recital: Pian
Tariff Reform: Some Pre-strategic Considerations
No full textWe consider the implications of improving on GATT/WTO tariff negotiations both the most-favoured-nation (MFN) clause and the twin Paretian rules (that negotiations leave the trading world on its efficiency locus and each participating country in a preferred position). It is shown that the set of tariff reforms that satisfy both rules (a) is always non-empty, (b) might include no reforms that end in world-wide free trade, (c) always includes reforms that are incompatible with free trade and (d) might include reforms that support a Pareto-optimal and Pareto-improving allocation but also support other allocations with neither of those characteristics.
Revolución en las redes: exploración de la arquitectura, funcionamiento y servicios SD-WAN
No full textActualmente vivimos en una sociedad con requerimientos en telecomunicaciones sin precedentes, donde todas las personas quieren acceder a un sinfín de servicios digitales desde cualquier lugar del mundo y en el menor tiempo posible, sumando a esto también una mayor tasa de transferencia y de descarga de sus datos. Dar cumplimiento a todo esto era prácticamente imposible hace unos años con las redes tradicionales LAN-WAN. Sin embargo, en el 2010 aproximadamente surge una nueva alternativa para satisfacer las necesidades de todos los usuarios, la red SD-WAN, basada en el funcionamiento de la SDN que proporciona un software muy avanzado capaz de centralizar toda una infraestructura WAN descentralizada y crear una forma más escalable y dinámica para administrarlas y hacer frente a los retos que presentan las nuevas tecnologías sin tener que administrar miles de dispositivos independientes de cada red.Ingeniero de Sistemas y ComputaciónPregrad
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
From MPLS to SD-WAN to ensure QoS and QoE in cloud-based applications
No full textQuality of Service (QoS) and Quality of Experience (QoE) are the most relevant requirements for new advanced services comprising integrated cooperation between processing, storage, sensing, and transmission capabilities. As reliance on technology grows, businesses increasingly turn to Wide Area Networks (WANs) connectivity solutions to ensure reliable and efficient communication between their locations and cloud data centers. With new applications with stringent requirements, QoS and QoE have become critical priorities for companies looking to remain competitive and provide a seamless customer experience. As a result, many organizations require reliable and high-performing WANs to effectively transmit critical data between their branches and cloud data centers. We examine Multi-Protocol Label Switching (MPLS technology), which is the historical choice for WANs but has significant disadvantages in cost and performance. Then, we analyze the novel Software-Defined Wide Area Network (SD-WAN) technology that allows for real-time flexible, dynamic reconfiguration of network devices to meet network measurements and service requirements. Furthermore, we introduce a first work of my Ph. D. that examines the use of a Reinforcement Learning algorithm in a new SD-WAN topology scenario in which we consider both direct WAN connections between Customer Premises Equipment (CPEs) located within enterprise premises and CPEs used as peering points for traffic routing. This paper presents our initial analysis of these technologies and the main ideas guiding me in my Ph. D. program
Three empirical essays on foreign direct investment, research and development, and insurance
No full textThis dissertation consists of three independent essays, all of which are empirical treatmentsof different determinants of economic growth.The first essay, which is in Chapter 2, evaluates the role economic freedom playsin mediating the effect of foreign direct investment (FDI) on growth. It tests whethercountries with sufficiently high level of economic freedom can exploit FDI more efficiently. Ituses cross-country observations from 84 countries for the 1976-2005 period. It applies athreshold regression which is flexible enough to accommodate the possibility that theimpact of FDI on growth ‘kicks in’ only when the level of economic freedom exceeds someunknown threshold. The results show that FDI has no direct (linear) effect on output growth.Instead, its impact is conditional on the level of economic freedom in the host countries.Only countries whose level of economic freedom has exceeded the threshold level ofeconomic freedom benefited from FDI inflows. In countries below the threshold level, FDIdeliver no beneficial effects. The findings are robust to several sensitivity checks andconsideration of endogeneity.The second essay (Chapter 3) tests the channels and magnitude of R&D spilloversfrom developed countries to East Asian countries (China, Korea, Malaysia, Singapore, andThailand). It examines three possible spillover channels - imports, inward FDI, and outwardFDI - using panel data for the period 1984-2005. It uses a novel panel estimator whichallows for cross-sectional dependence and provides country-specific estimates of R&Deffects. There are several important conclusions emerge. First, both domestic and foreignR&D are important for productivity improvements. Second, imports are the most importantchannel of spillovers while spillover effects via FDI in uncertain. Third, there is someevidence that domestic R&D helps to increase the incidence of R&D spillovers, especiallyvia import channel. Fourth, the U.S. is a relatively stronger provider of spillovers thanJapan.Chapter 4, which is the final essay, examines the impact of insurance sectordevelopment on output growth, capital accumulation and productivity improvement. It usespanel data from 52 countries for the period 1981-2005, and applies a recent generalizedmethod-of moments (GMM) dynamic panel estimator. The results show that thedevelopment of insurance sector is important for long-run output growth, capitalaccumulation and productivity growth. For developing countries, insurance affects growthpredominantly through capital accumulation while in developed countries it enhancesproductivity growth. The findings are robust to biases introduced by unobserved countryspecificeffects, simultaneity, weak or numerous instruments. It remains valid even aftercontrolling for bank and stock market developments
TUNABLE IMMUNOSTIMULATORY NANOCARRIER FOR IMPROVING CANCER IMMUNOCHEMOTHERAPY
No full textChemotherapy is the mainstream method of cancer therapy. In addition to direct cytotoxic effects on tumor cells, chemotherapy can induce antitumor immunity. The shortcomings of traditional chemotherapy are attributed to low solubility in aqueous solutions, rapid elimination, and lack of selectivity. In addition, cancers rapidly establish an immunological tolerance to the chemotherapy-induced antitumor immunity. The immune tolerance and suppression represent a major barrier to successful cancer treatment and are potential target for new therapeutics. Recent evidence demonstrates that an important mechanism underlying the immunological tolerance is the upregulated indoleamine-2,3-dioxygenase (IDO) expression in tumor cells or tumor-associated immune cells. Therefore, IDO pathway inhibition offers a potential for enhanced anti-tumor responses of chemotherapeutic agents.
In our previous study, systemic delivery of paclitaxel (PTX) using the PEG2k-Fmoc-NLG nanocarrier, a PEG-modified prodrug of NLG919 (an IDO1 selective inhibitor), led to a significantly enhanced anti-tumor effect of PTX by reactivating immunogenic responses. In this study we examined the therapeutic potential of a new nanocarrier that is based on a prodrug of 1-methyl-d-trptophan (1-D-MT). 1-D-MT is also an IDO inhibitor but has been reported to enhance antitumor immunity via different mechanism. The nanocarrier will be developed via reversible addition fragmentation transfer (RAFT) polymerization. In addition to the simplicity of the synthesis of the nanocarrier, the amount of 1-D-MT that can be incorporated into the polymer can be readily tuned via controlling the degree of polymerization.
Two 1-D-MT-based monomers were first synthesized followed by RAFT polymerization to give well-defined di-block co-polymers. Several polymers were synthesized and they varied in the molar ratio of hydrophilic POEG block/hydrophobic 1-D-MT block and the type of linker. Preliminary data showed that a 1-D-MT polymer with ethylene glycol vinyl ether linker can only load limited amounts of PTX and doxorubicin (DOX). Introduction of a vinylbenzyl chloride linker led to an improvement in drug loading capacity. More studies on the biophysical and biological properties of the new carrier are currently underway
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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