1,720,982 research outputs found
MAPPING THE BOVINE CYSTIC FIBROSIS GENE
No full textProgram year: 1992/1993Digitized from print original stored in HDRHuman cDNA probe H1. 6 (clone 10-1) encoding cystic fibrosis transmembrane conductance regulator (CFTR) was used to map the bovine homolog of CFTR. Using a panel of bovine X rodent hybrid somatic cells, the homolog was mapped to bovine syntenic group U13. CFTR is 97.7% concordant with syntenic markers T-cell receptor beta (TCRB) and P-glycoprotein 3 (PGY3) previously mapped on U13. The comparative gene maps of CFTR, TCRB, and PGY3 on human chromosome 7, bovine syntenic group U13, and mouse chromosomes 5 and 6 indicate considerable evolutionary conservation
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Mapping and identification of genes involved in human craniofacial syndromes
No full textCraniofacial development is a complex developmental process requiring many cell types, cell movements, cell interactions, and the orchestrated expression of many genes. Numerous human syndromes are associated with defects in craniofacial development. This thesis is a molecular study of two such syndromes, craniofrontonasal syndrome (CFNS) and holoprosencephaly (HPE). By identifying the genetic causes of these syndromes, we hope to further our understanding of the developmental processes participating in the normal formation of the brain and face. We have accomplished several goals towards the identification of specific genes involved in CFNS and HPE. First, we mapped CFNS by linkage analysis to Xp22. Subsequent mapping of a cytogenetic deletion in a CFNS patient narrowed the CFNS critical region defined by the linkage analysis. Through detailed phenotypic analysis, we also showed that females are more severely affected than males. This is an unusual phenotypic pattern for X-linked inheritance. On the HPE project, the HPE3 region was cytogenetically defined in relation to Sonic Hedgehog (SHH). Deletions or translocations involving position effects and SHH were shown to cause HPE. Also on the HPE project, the HPE2 minimal critical region (MCR) was defined. Because the SIX3 gene was an excellent candidate gene, it was cloned from the region. After screening the entire SIX3 gene for mutations in HPE patients, we determined it to be the HPE2 gene as mutations in the homeodomain were identified. Translocations were also found to map outside the coding region of SIX3 indicating a position effect with SIX3 similar to that observed with SHH. Functional studies of Six-3 in the developing chick embryo were attempted, but no conclusions could be made from the results. Finally, a literature review of the molecular genetics of HPE was compiled. Through this review it became more evident how all the identified HPE genes and likely candidate genes related to each other via signaling pathways such as the SHH, TGFβ, and retinoic acid pathways. These studies have contributed to our understanding of the growing complexities of craniofacial development
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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