170,125 research outputs found
sj-docx-1-ppn-10.1177_15271544221089657 - Supplemental material for Structural Racism in America: A Summative Content Analysis of National Nursing Organization Statements
No full textSupplemental material, sj-docx-1-ppn-10.1177_15271544221089657 for Structural Racism in America: A Summative Content Analysis of National Nursing Organization Statements by Naila C. Russell and Sherrie Flynt Wallington in Policy, Politics, & Nursing Practice</p
A Land Carbon Management Plan for the Wallington Estate
No full textThe National Trust aims to enter the majority of tenanted farms on the Wallington Estate into Higher Level Stewardship (HLS) agreements. The agreements aim to enhance biodiversity, the historic environment, access and landscape features however the impact on soil organic carbon (SOC) and biomass carbon (C) is also of importance. Multiple options may be available to achieve each particular aim with differing impacts on SOC and biomass C. The project will identify land management options that achieve each primary objective (enhance biodiversity, the historic environment, access and landscape features) but also maximise C without increasing emissions of other greenhouse gases (GHGs). An inventory of the potential C that may be sequestered by introduction of HLS on The Wallington Estate will be undertaken and the impact on other greenhouse gas (GHG) emissions indicated. Current SOC content measured by the University of Durham will be used as the baseline against which any predicted change in C by implementing existing or new HLS options may be compared. Using the data generated by Bell and Worrall (2009) and Defra project BD2302 (Warner et al., 2008a) this project will evaluate those HLS options most suited to each individual tenancy within the Wallington Estate and calculate their potential to enhance soil or biomass C. Those with the greatest potential will be subject to further analysis to calculate their impact after a period of 20 years. Their practicability will be further assessed taking into account other objectives (farm productivity, soil and water protection and biodiversity). A programme of monitoring will be devised to ascertain the effectiveness of selected options relative to the predicted calculations. As part of this projects function as a ‘blueprint’ for other land holdings step-by-step guidance will be produced to allow the method to be implemented on other National Trust estates
"Long term deformation of epoxy glued glulam portal frame knee joints" May 2009.
No full textThis project was initiated to resolve uncertainty regarding the long-term performance of epoxied rod connections in glue laminated timber (glulam), specifically the long term-deformations associated with beam-column moment joints. The excellent short-term performance of this type of connection is well known. However there is some scepticism in industry over the long-term performance. The behaviour of this connection when subjected to long term loading is thought to be primarily affected by creep in the timber and heterogeneity of the cross section. It has been hypothesised that the stress distribution at the beam-column interface may change over time leading to a localisation of stresses, rotations within the joint and ultimately, excessive deflections of the frame at serviceability limit states. Furthermore, crushing of the timber perpendicular to the grain may occur in the long-term as a result of the stress redistribution over time which could cause failure at ultimate limit state. In order to investigate the long term performance, two types of experimental testing were carried out in this project: (i) long term testing of several frames and lever specimens; and (ii) short term testing of several smaller glulam specimens.
Four frames with a “C” shaped layout (i.e. one column and two beams) were tested. Two of these frames used the “fully-epoxied” connection, where the steel rods were epoxied along the full length, whilst the other two frames used the “tensioned half epoxied” connection, where the steel rods were epoxied into one member and tensioned to the other. Two different geometries were tested (the column running past the end of the beam and the beam extending over the top of the column).
The lever specimens were designed to individually measure the different components of creep. These measured the creep of the timber itself (both parallel and perpendicular to the grain), the creep of a timber specimen with epoxied rods at both ends, and the creep of the glue alone.
Short-term bending, compression and pullout tests were carried out on glulam according to ISO recommendations to characterise the timber used in this project. The results of the compressive strength tests perpendicular to the grain gave compressive stresses that were approximately 50% of that specified in the New Zealand Timber Standard. This is of concern and needs attention given the importance of this property when designing any joints where structural performance depends on bearing perpendicular to grain.
Some important conclusions have been reached. The results from the Glulam Lever Specimens showed that creep perpendicular to the grain may be up to 8 times greater than that parallel to the grain. The remaining lever specimens showed that long term pullout deformations are likely to be negligible in dry conditions. The “fully epoxied” connection performed significantly better than the “tensioned half epoxied” connection. This is due to better transfer of forces in the “fully epoxied” connection and hence very little reliance on the compressive strength of timber perpendicular to the grain. Creep of timber was found to mainly affect the deflection of the frame specimens, as no significant stress redistribution was noticed in the long-term between timber and rods. It was also pointed out that a significant contribution to the total deflection is given by the flexibility semi-rigidity of the connection itself, which is usually designed as a rigid joint but should more realistically be considered as a semi-rigid connection. Design equations have been proposed and are shown to correlate well with the results obtained. Lastly, a method has been described to estimate the long-term stresses in the glulam and steel elements
"Long term deformation of epoxy glued glulam portal frame knee joints" May 2009.
No full textThis project was initiated to resolve uncertainty regarding the long-term performance of epoxied rod connections in glue laminated timber (glulam), specifically the long term-deformations associated with beam-column moment joints. The excellent short-term performance of this type of connection is well known. However there is some scepticism in industry over the long-term performance. The behaviour of this connection when subjected to long term loading is thought to be primarily affected by creep in the timber and heterogeneity of the cross section. It has been hypothesised that the stress distribution at the beam-column interface may change over time leading to a localisation of stresses, rotations within the joint and ultimately, excessive deflections of the frame at serviceability limit states. Furthermore, crushing of the timber perpendicular to the grain may occur in the long-term as a result of the stress redistribution over time which could cause failure at ultimate limit state. In order to investigate the long term performance, two types of experimental testing were carried out in this project: (i) long term testing of several frames and lever specimens; and (ii) short term testing of several smaller glulam specimens.
Four frames with a “C” shaped layout (i.e. one column and two beams) were tested. Two of these frames used the “fully-epoxied” connection, where the steel rods were epoxied along the full length, whilst the other two frames used the “tensioned half epoxied” connection, where the steel rods were epoxied into one member and tensioned to the other. Two different geometries were tested (the column running past the end of the beam and the beam extending over the top of the column).
The lever specimens were designed to individually measure the different components of creep. These measured the creep of the timber itself (both parallel and perpendicular to the grain), the creep of a timber specimen with epoxied rods at both ends, and the creep of the glue alone.
Short-term bending, compression and pullout tests were carried out on glulam according to ISO recommendations to characterise the timber used in this project. The results of the compressive strength tests perpendicular to the grain gave compressive stresses that were approximately 50% of that specified in the New Zealand Timber Standard. This is of concern and needs attention given the importance of this property when designing any joints where structural performance depends on bearing perpendicular to grain.
Some important conclusions have been reached. The results from the Glulam Lever Specimens showed that creep perpendicular to the grain may be up to 8 times greater than that parallel to the grain. The remaining lever specimens showed that long term pullout deformations are likely to be negligible in dry conditions. The “fully epoxied” connection performed significantly better than the “tensioned half epoxied” connection. This is due to better transfer of forces in the “fully epoxied” connection and hence very little reliance on the compressive strength of timber perpendicular to the grain. Creep of timber was found to mainly affect the deflection of the frame specimens, as no significant stress redistribution was noticed in the long-term between timber and rods. It was also pointed out that a significant contribution to the total deflection is given by the flexibility semi-rigidity of the connection itself, which is usually designed as a rigid joint but should more realistically be considered as a semi-rigid connection. Design equations have been proposed and are shown to correlate well with the results obtained. Lastly, a method has been described to estimate the long-term stresses in the glulam and steel elements
"Moment joints in timber frames using glued-in steel rods: experimental investigation of long-term performance"
No full text"Moment joints in timber frames using glued-in steel rods: experimental investigation of long-term performance"
No full textSphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression
No full textAbstract not availableCraig T. Wallington-Beddoe, Jason A. Powell, Daochen Tong, Stuart M. Pitson, Kenneth F. Bradstock and Linda J. Bendal
Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies
No full textLink to a related website: https://doi.org/10.1038/s41420-020-00380-1, Author CorrectionConventional chemotherapy-based drug combinations have, until recently, been the backbone of most therapeutic strategies for cancer. In a time of emerging rationale drug development, targeted therapies are beginning to be added to traditional chemotherapeutics to synergistically enhance clinical responses. Of note, the importance of pro-apoptotic ceramide in mediating the anti-cancer effects of these therapies is becoming more apparent. Furthermore, reduced cellular ceramide in favour of pro-survival sphingolipids correlates with tumorigenesis and most importantly, drug resistance. Thus, agents that manipulate sphingolipid metabolism have been explored as potential anti-cancer agents and have recently demonstrated exciting potential to augment the efficacy of anti-cancer therapeutics. This review examines the biology underpinning these observations and the potential use of sphingolipid manipulating agents in the context of existing and emerging therapies for haematological malignancies.Alexander C. Lewis, Craig T. Wallington-Beddoe, Jason A. Powell and Stuart M. Pitso
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia
No full textLink to a related website: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15097, Open Access via UnpaywallAbstract not availableCraig T. Wallington‐Beddoe, Vicki Xie, Daochen Tong, Jason A. Powell, Alexander C. Lewis, Lorena Davies, Stuart M. Pitson, Kenneth F. Bradstock
Linda J. Bendal
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