1,529 research outputs found
Clinical and radiological recurrence after childhood arterial ischemic stroke
No full textBackground: Data on rates and risk factors for clinical and radiological recurrence of childhood arterial ischemic stroke (AIS) might inform secondary prevention strategies.
Methods and Results: Consecutive Great Ormond Street Hospital patients with first AIS were identified retrospectively (1978–1990) and prospectively (1990–2000). Patients underwent repeat neuroimaging at the time of clinical recurrence or, if asymptomatic, at least 1 year after AIS. Cox and logistic regression analyses were used to explore the relationships between risk factors and clinical and radiological recurrence, respectively. A total of 212 patients were identified, of whom 97 had another prior diagnosis. Seventy-nine children had a clinical recurrence (29 strokes, 46 transient ischemic attacks [TIAs], 4 deaths with reinfarction 1 day to 11.5 years (median 267 days) later); after 5 years, 59% (95% confidence interval, 51% to 67%) were recurrence free. Moyamoya on angiography and low birth weight were independently associated with clinical recurrence in the whole group. Genetic thrombophilia was associated with clinical recurrence in previously healthy patients, independent of the presence of moyamoya. Sixty of 179 patients who had repeat neuroimaging had radiological reinfarction, which was clinically silent in 20. Previous TIA, bilateral infarction, prior diagnosis (specifically immunodeficiency), and leukocytosis were independently associated with reinfarction. Previous TIA and leukocytosis were also independently associated with clinically silent reinfarction.
Conclusions: Clinical and radiological recurrence are common after childhood AIS. The risk of clinical recurrence is increased in children with moyamoya and, in previously healthy patients, in those with genetic thrombophilia. Preexisting pathology, including immunodeficiency, and persistent leukocytosis are risk factors for radiological recurrence, which suggests a potential role for chronic infection
Biogeochemical redox proxies in sediments from Dotternhausen during the Toarcian (Early Jurassic)
No full textAuthor contributions:
The lead author is Angela L. Coe. Measurements were performed by Stephan M. Harding, with supervision of Angela L. Coe and Anthony S. Cohen. Measurements were gathered, processed and analysed by Itzel Ruvalcaba Baroni
Biogeochemical redox proxies in sediments from Yorkshire during the Toarcian (Early Jurassic)
No full textAuthor contributions:
The lead author is Angela L. Coe. Measurements were performed by Stephan M. Harding, with supervision of Angela L. Coe and Anthony S. Cohen. Measurements were gathered, processed and analysed by Itzel Ruvalcaba Baroni
Investigation of risk factors in children with arterial ischemic stroke
No full textWe present data on the known risk factors encountered in children presenting with a first arterial ischemic stroke to a single tertiary center over 22 years. Two hundred twelve patients (54% male; median age, 5 years) were identified. One hundred fifteen (54%) were previously healthy. Cerebral arterial imaging was undertaken in 185 patients (87%) and was abnormal in 79%. Of 104 previously healthy patients investigated with echocardiography, only 8 had abnormal studies. Genetic or acquired conditions causing thrombophilia were rare. Forty percent of patients were anemic, and 21% either had elevated total plasma homocysteine or were homozygous for the t-MTHFR mutation. Trauma and previous varicella zoster infection were significantly more common in the previously healthy group. There was a significant association between cerebral arterial abnormalities and systolic blood pressure greater than 90th percentile and a trend for an association with varicella within the previous year. Clinical history and examination usually identify underlying risk factors and precipitating triggers for arterial ischemic stroke in childhood. Cerebral arterial imaging is usually abnormal, but echocardiography and prothrombotic screening are commonly negative
Wellcome Witnesses to Twentieth Century Medicine: Volume 1
No full textAnnotated and edited transcript of four Witness Seminars. Introduction by E M Tansey First published by the Wellcome Trust, 1997. ©The Trustee of the Wellcome Trust, London, 1997.In Volume One (Occasional Publication no. 4, 1997).All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of four Witness Seminars. Introduction by E M Tansey.Annotated and edited transcript of four Witness Seminars. Introduction by E M Tansey.Annotated and edited transcript of four Witness Seminars. Introduction by E M Tansey.Annotated and edited transcript of four Witness Seminars. Introduction by E M Tansey.Four Witness Seminar transcripts of meetings held between 1993 and 1996: ‘Technology Transfer in Britain: The case of Monoclonal Antibodies’ (E M Tansey and P P Catterall, eds); ‘Self and Non-Self: A History of Autoimmunity’ (E M Tansey, S V Willhoft and D A Christie, eds); ‘Endogenous Opiates’ (E M Tansey and D A Christie, eds); ‘The Committee on Safety of Drugs’ (E M Tansey and L A Reynolds, eds). Introduction by E M Tansey, ‘What is a Witness Seminar’, separate index for each meeting. Tansey E M, Catterall P P, Christie D A, Willhoft S V, Reynolds L A. (eds) (1997) Wellcome Witnesses to Twentieth Century Medicine, volume 1. London: The Wellcome Trust.The Wellcome Trust is a registered charity, no. 210183
Food and eating in fiction since 1950 with particular reference to the writing of Angela Carter, Doris Lessing, Michele Roberts and Alice Thomas Ellis.
No full textPhDEating is a fundamental activity. What people eat, how and with whom, what
they feel about food, what they do or do not want to eat and why - even who
they eat - are of crucial significance in any reading of human behaviour.
In this thesis, I consider the diverse and complex uses of food and eating
in fiction since 1950, especially that written by women. I argue both that food
and eating carry much of the meaning of a novel or story and that the acts of
cooking, feeding and eating depicted are inseparable from issues of power and
control: individually, interpersonally, culturally, politically.
My discussion centres on the writing of Angela Carter, Doris Lessing,
Michele Roberts and Alice Thomas Ellis. Drawing on psychoanalytic theory,
sociology, anthropology, Foucault, Bakhtin and others, the thesis aims to
construct an interdisciplinary perspective which both resists reductive
interpretations and emphasises the centrality, complexity and diversity of food
and eating in literature in our culture.
I begin with an examination of the ambiguities of maternal feeding and
nurturing, moving on to explore the links between appetite, eating and sexuality.
I explore cannibalism and vampirism as manifestations of oppression, but also as
indicating insatiable emptiness and transgressive appetite. The body itself is
crucial, and my argument considers the paradox of not eating as
control/enslavement, also tracing self-starvation as a positive route towards
wholeness and connection. The last part of my argument focuses on social
eating, examining conventions, rituals and food itself in connection with power
relations, and finally considers how we might truly speak of food and eating in
the context of society as a whole
Regulation of store-operated calcium channel by Mitsugumin29 in skeletal muscle aging:
No full textThe study of store-operated Ca2+ channel entry (SOCE) and its role in muscle contractility in young and aged skeletal muscle necessitates a thorough knowledge of the Ca2+ signaling from the sarcoplasmic reticulum (SR) that activates SOCE. Yet, all of the molecular components involved have yet to be fully elucidated, as neither T-tubule voltage sensors, nor SR ryanodine receptor Ca2+ channels, together or independently, are necessary or sufficient for the establishment of a close association between the T-tubule and SR membranes. Therefore, other protein components must be involved for the formation of triad junctional complexes.
Mitsugumin29 (MG29), a protein localized to the triad junction, may function as a structural component involved in the coupling between the SR and T-tubule, as abnormalities in both T-tubule and SR membranes have been reported in mg29(-/-) mice. In addition, muscles from these mice share many morphological and functional characteristics with muscle from aged mice, including increased susceptibility to fatigue, defective SR Ca2+ release and defective SOC function. Either of these may be responsible for the altered Ca2+ signaling in skeletal muscle during exercise and aging.
Our data suggests that SOCE is not merely important for skeletal muscle function in aging; but, it is also required for maintenance of Ca2+ signaling during repetitive stimulation under intensive muscle activity (i.e., fatigue) in the healthy state. In addition, we propose that SOCE diminishes with age, contributing to the age-associated muscle weakness. Finally, we find that while SOCE is a functional marker of muscle performance in aging, MG29 is a molecular marker, as SOCE is compromised in aged wild type mice through the decreased expression of MG29. Therefore, mg29(-/-) mice can serve as an appropriate model for the study of skeletal muscle aging. Through this project, we have begun to understand the physiological function of SOCE and MG29 and their contribution to muscle contractility in both young and aged mice.Ph.D.Includes bibliographical references (p. 71-87)by Angela M. Thornto
Angela Carter as Fiction: Refiguring the real author as Performative Author
No full textIn a 2006 article in The Independent, Christina Patterson echoes Gore Vidal by stating ‘Death, as any biographer knows, can be an excellent career move’. Commenting on a brief revival of Angela Carter’s work in 2006 concomitant with Emma Rice’s bringing of Nights at the Circus to the stage, and Vintage’s reissuing of six of her works with new introductions, Patterson refers to Carter’s ‘whole new lease on life’ suggesting the metamorphic potential and curious temporality of the authorial figure with regard to reader reception. The Vintage editions suggest, as Stephen Benson observes, the ‘legend’ of the ‘Carter effect’, identified by The British Academy Humanities Research Board, which distributes postgraduate studentships. This ‘Carter’ effect was also fostered by the theatricality of Carter’s authorial performances. Sarah Gamble has observed the ‘screen’ of authorial identity upon which readers are led to project impressions, which functions as a ‘hall of mirrors’ in relation to penetrating to the authentic author. Such attempts at authorial effacement and control are certainly not unusual. However, Carter’s postmodern enactment of the play of surfaces in the realm of authorial identity appears to heighten the consequent shifting of boundaries between fiction and life staged in her fiction. This article will address the interaction between the games with identity inscribed in Carter’s short stories and the complex identity and temporality of the Performative Author
MARC 21 para recursos contínuos.
No full textTradução e adaptação de MARC 21 Format for Bibliographic Data e MARC 21 Format for Holdings Data, da Network Development and MARC Standards Office, da Library of Congress, USA, por Angela Salles
MARC 21 para recursos contínuos
No full textTranslation and adaptation of the MARC 21 Format for Bibliographic Data, and MARC 21 Format for Holdings Data, Network Development and MARC Standards Office, Library of Congress, USA, by Angela Salles. Rio de Janeiro, 2010. 2 v. V.1 MARC 21 format for bibliographic data (updated until October 2010). V.2 MARC 21 format for data collection (Holdings) (updated until October 2008)
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