1,302 research outputs found
Substituent and temperature effects on the reactions of benzylchlorocarbene with alcohol
No full textPT: J; CR: DOLBY LJ, 1966, J ORG CHEM, V31, P110 FRENKING G, 1984, TETRAHEDRON, V40, P2123 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 GRILLER D, UNPUB GRILLER D, 1982, J AM CHEM SOC, V104, P5549 GRILLER D, 1984, J AM CHEM SOC, V106, P198 KIRMSE W, 1971, CARBENE CHEM KIRMSE W, 1981, J AM CHEM SOC, V103, P5935 LIU MTH, 1984, J CHEM SOC CHEM COMM, P1062 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 MARCH J, 1985, ADV ORG CHEM, P244 MOSS RA, 1975, CARBENES, V1 MOSS RA, 1975, CARBENES, V2 MOSS RA, 1983, TETRAHEDRON LETT, V24, P685 MUROV SL, 1973, HDB PHOTOCHEMISTRY, P147 PLATZ MS, 1982, J AM CHEM SOC, V104, P6494 SCHLOSSER M, 1967, CHEM BER, V100, P3901 SCHMID GH, 1978, J ORG CHEM, V43, P777 SENTHILNATHAN VP, 1980, J AM CHEM SOC, V102, P7637 TANAKA R, 1971, TETRAHEDRON, V27, P2651 TOMIOKA H, 1983, J AM CHEM SOC, V105, P5053 TOMIOKA H, 1984, J AM CHEM SOC, V106, P454 TOMIOKA H, 1984, J CHEM SOC CHEM COMM, P476 TOMIOKA H, 1984, TETRAHEDRON LETT, V25, P4413 WARNER P, 1984, J ORG CHEM, V49, P3666 WARNER PM, 1984, J AM CHEM SOC, V106, P5366 WRIGHT BB, 1984, J AM CHEM SOC, V106, P4175; NR: 27; TC: 9; J9: J CHEM SOC PERKIN TRANS 2; PG: 8; GA: D7012Source type: Electronic(1
Effect of diazirine concentration on the reaction of 3-benzyl-3-chlorodiazirine with methanol
No full textPT: J; CR: GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 GRILLER D, 1982, J AM CHEM SOC, V104, P5549 LIU MTH, 1984, J CHEM SOC CHEM COMM, P1062 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 LIU MTH, 1985, J ORG CHEM, V50, P3218 LIU MTH, 1985, TETRAHEDRON LETT, V26, P3071 LIU MTH, 1986, J CHEM SOC PERK T 2, P1233 LIU MTH, 1986, J PHYS CHEM-US, V90, P75 LIU MTH, 1987, CHEM DIAZIRINES, V1, CH5 TOMIOKA H, 1984, J AM CHEM SOC, V106, P454 TOMIOKA H, 1986, J CHEM SOC CHEM COMM, P1364; NR: 11; TC: 5; J9: J CHEM SOC PERKIN TRANS 2; PG: 3; GA: L7207Source type: Electronic(1
Photolysis and thermolysis of 3-normal-butyl-3-phenyldiazirine
No full textPT: J; CR: BRADLEY GF, 1977, J CHEM SOC P2, P1214 FREY HM, 1966, ADV PHOTOCHEM, V4, P225 LIU MTH, 1973, CAN J CHEM, V51, P2393 LIU MTH, 1977, CAN J CHEM, V55, P3596 LIU MTH, 1979, CAN J CHEM, V57, P1299 SMITH NP, 1979, J CHEM SOC P2, P213 SMITH RAG, 1975, J CHEM SOC P2, P686; NR: 7; TC: 9; J9: J CHEM SOC PERKIN TRANS 2; PG: 5; GA: KZ442Source type: Electronic(1
Formation of indolizines by the addition of α-chloroacrylonitrile to pyridinium ylides: regioselectivity and Hammett correlation
No full textPT: J; CR: BENSASSON R, 1971, T FARADAY SOC, V67, P1904 BONNEAU R, 1989, J CHEM SOC CHEM COMM, P510 CARMICHAEL I, 1986, J PHYS CHEM REF DATA, V15, P1 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 LIU MTH, 1987, CHEM DIAZIRINES, CH5 LIU MTH, 1987, TETRAHEDRON LETT, P1011 PUGMIRE RJ, 1971, J AM CHEM SOC, V98, P1887 SOUNDARAJAN N, 1988, TETRAHEDRON LETT, P3419 TURRO NJ, 1980, J AM CHEM SOC, V102, P7578 UCHIDA T, 1976, SYNTHESIS-STUTTGART, P209; NR: 10; TC: 10; J9: J CHEM SOC PERKIN TRANS 1; PG: 2; GA: AL500Source type: Electronic(1
on the thermal decomposition of diazirines
No full textPT: J; CR: BIGOT B, 1978, J AM CHEM SOC, V100, P6576 BRADLEY GF, 1977, J CHEM SOC P2, P1214 BRUNNER J, 1980, J BIOL CHEM, V255, P3313 DIDERICH G, 1972, HELV CHIM ACTA, V55, P2103 FLEMING I, 1980, FRONTIER ORBITALS OR GRILLER D, 1982, J AM CHEM SOC, V104, P5549 JENNINGS BM, 1976, J AM CHEM SOC, V98, P6416 LAHMANI F, 1976, J PHYS CHEM-US, V80, P2623 LANGANIS ED, 1983, J AM CHEM SOC, V105, P7457 LIU MTH, 1972, J PHYS CHEM-US, V76, P797 LIU MTH, 1973, CAN J CHEM, V51, P2393 LIU MTH, 1974, J CHEM SOC P2, P937 LIU MTH, 1977, CAN J CHEM, V55, P3596 LIU MTH, 1982, CHEM SOC REV, V11, P127 MOORE CB, 1964, J CHEM PHYS, V41, P3504 SCHMITZ E, 1965, CHEM BER, V98, P2509 SCHMITZ E, 1967, CHEM BER, V100, P2093 SCHMITZ E, 1971, 23RD INT C PUR ALL C, V2, P283 SHEPARD RA, 1967, J ORG CHEM, V32, P3197 SHILOV AE, 1968, TETRAHEDRON LETT, P4177 SMITH NP, 1979, J CHEM SOC P2, P213 SMITH RAG, 1975, J CHEM SOC P2, P686 SNYDER JP, 1972, TETRAHEDRON LETT, P4347 TAYLOR EC, 1979, CHEM REV, V79, P181 TURRO NJ, 1980, J AM CHEM SOC, V102, P7576 TURRO NJ, 1982, J AM CHEM SOC, V104, P1754 VOIGT E, 1975, CHEM BER, V108, P3326 ZOLLINGER H, 1978, ANGEW CHEM INT EDIT, V17, P141; NR: 28; TC: 8; J9: J CHEM SOC PERKIN TRANS 2; PG: 4; GA: A2035Source type: Electronic(1
Zawartość wybranych pierwiastków w siewkach linii wsobnych żyta ozimego (Secale cereale L.)
No full text9 inbred lines were chosen for the experiment (L176, L230, CH7, L154, M353, L4, L299, L310, L28) of the winter rye S25 generation (Secale cereale L.). The 5 day-old seedlings of the line were treated with a cadmium sulfate solution at a concentration of 10–6 and 10–4 M for 36 h, and then placed on the Hoagland nutrient. The control materials were comprised of seedlings of the line growing on the same nutrient. The twenty-one day old seedlings were mineralized and the content of the following elements was marked: cadmium, magnesium, zinc, calcium, manganese and potassium, using the Perkin-Elmer1100 atomic absorption spectrophotometer. The lowest content of cadmium amounting to several mg/kg was observed in the control combination. The content of chemical elements in all inbred lines was higher at a lower concentration of cadmium 10–6 M/36 h (with the exception of L230 and L299 line).Do doświadczenia wybrano 9 linii wsobnych (L176, L230, CH7, L154, M353, L4, L299, L310 i L29) pokolenia S25 żyta ozimego (Secale cereale L.). Pięciodniowe siewki linii traktowano roztworem siarczanu kadmu o stężeniach 10-6 i 10-4 M przez 36 h, a następnie przenoszono je na pożywkę. Materiał kontrolny stanowiły siewki linii rosnące na pożywce Hoaglanda. Dwudziestojednodniowe siewki mineralizowano i oznaczono zawartość następujących pierwiastków: kadm, magnez, cynk, wapń, mangan i potas, przy użyciu spektrofotometru absorpcji atomowej firmy Perkin-Elmer1100. Najniższą zawartość kadmu wynoszącą kilka mg/kg zanotowano w kombinacji kontrolnej. Zawartość biogennych pierwiastków była wyższa u wszystkich linii wsobnych żyta w niższym stężeniu kadmu 10-6 M/36 h (z wyjątkiem linii L230 i L299)
The thermal decomposition of diazirines: 3-(3-methyldiazirin-3-yl)propan-1-ol and 3-(3-methyldiazirin-3-yl)propanoic acid
No full textPT: J; CR: BIGOT B, 1978, J AM CHEM SOC, V100, P6575 BRIDGE MR, 1969, J CHEM SOC A, P91 CHURCH RFR, 1970, J ORG CHEM, V35, P2465 CLOSS GL, 1965, J AM CHEM SOC, V87, P4270 EFFIO A, 1980, J AM CHEM SOC, V102, P1734 FIGUERA JM, 1976, AN QUIM, V72, P737 FIGUERA JM, 1978, J CHEM SOC F1, V74, P809 FIGUERA JM, 1979, J PHOTOCHEM, V10, P473 FREY HM, 1963, J CHEM SOC, P3514 FREY HM, 1964, J CHEM SOC, P4700 FREY HM, 1965, J CHEM SOC, P1700 FREY HM, 1965, J CHEM SOC, P3101 FREY HM, 1966, J CHEM SOC A, P968 FREY HM, 1977, J CHEM SOC F1, V73, P2010 FREY HM, 1979, J CHEM SOC A, P1916 GANZER GA, 1986, J AM CHEM SOC, V108, P1517 GRILLER D, 1982, J AM CHEM SOC, V104, P5549 LAL D, 1974, J AM CHEM SOC, V96, P6355 LIU MTH, 1972, INT J CHEM KINET, V4, P229 LIU MTH, 1972, J PHYS CHEM-US, V76, P797 LIU MTH, 1973, CAN J CHEM, V51, P2393 LIU MTH, 1974, J CHEM SOC P2, P937 LIU MTH, 1977, CAN J CHEM, V55, P3596 LIU MTH, 1982, CHEM SOC REV, V11, P127 LIU MTH, 1984, J CHEM SOC CHEM COMM, P1062 LIU MTH, 1984, TETRAHEDRON, V40, P887 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 LIU MTH, 1986, J CHEM SOC PERK T 2, P211 LIU MTH, 1987, CHEM DIAZIRINES, V1, P111 MANSOOR AM, 1966, TETRAHEDRON LETT, P1753 MANSOOR M, 1967, THESIS U SOUTHAMPTON MOSS RA, 1984, TETRAHEDRON LETT, V25, P1023 NEUVARAND EW, 1967, J PHYS CHEM-US, V71, P1229 SCHMID P, 1979, INT J CHEM KINET, V11, P333 SHERIDAN RS, 1984, J AM CHEM SOC, V106, P436 SKELL PS, 1972, TETRAHEDRON, V28, P3571 SMITH NP, 1979, J CHEM SOC P2, P213 SMITH RAG, 1975, J CHEM SOC P2, P686 VOIGT E, 1975, CHEM BER, V108, P3326; NR: 39; TC: 8; J9: J CHEM SOC PERKIN TRANS 2; PG: 7; GA: DD960Source type: Electronic(1
Structural studies of saccharides and glycopeptides in aqueous solution by 1H NMR spectroscopy
No full textThe first part of this thesis describes the use of hydroxy protons for 1H NMR conformational studies of saccharides and small glycopeptide performed in aqueous solution. The conformations of the disaccharide b-D-GlcpNAc-(1®4)-b-D-GlcNAc and of the glycoside b-D-Galp-(1®3)-a-D-GalpNAc-O-Me have been investigated and compared to those of the amino acid linked counterparts b-D-GlcpNAc-(1®4)-b-D-GlcNAc-N-Asn and b-D-Galp-(1®3)-a-D-GalpNAc-O-Ser. For this, the hydroxy proton chemical shifts, vicinal coupling constants, temperature coefficients, exchange rates with water and NOEs were measured. The V[b-D-Galp-(1®3)-a-D-GalpNAc-(1®]THPGY glycopeptide was also investigated. Information about hydrogen bonding interactions and hydration could be obtained. The second part of this thesis describes the 1H NMR studies of the solution conformation of the conotoxin contulakin-G and five analogues. The five analogues had different biological activities, all being less active than contulakin-G. The conformational studies were performed in an attempt to correlate the structure to the activity. Contulakin-G is a 16 amino acid O-glycosylated glycopeptide, which originally was isolated from the venom of the Cone snail Conus geographus. It has the sequence ZSEEGGSNAT*KKPYIL with the disaccharide b-D-Galp-(1®3)-a-D-GalpNAc attached to the threonine residue in position 10. It has entered phase II clinical trials for short-term management of post-operative pain. The five analogues are the non-glycosylated peptide, one glycopeptide with the monosaccharide a-D-GalpNAc attached to Thr10, one with the disaccharide attached at Ser7, and two enantiomeric analogues where the disaccharide was attached at the L-Ser10 and D-ser10 residues, respectively. The NMR studies showed that in all compounds, the peptide predominantly existed in extended conformations. Transient populations of folded conformations were found in the glycosylated peptides. The two most active compounds, contulakin-G, and the (D-Ser10) glycosylated analogue, displayed some similar conformational features
Ciclização intramolecular de 2-(w-Bromoalquiloxi) anilinas /
No full textDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas.Ciclizações intramoleculares podem ser estudadas como modelos miméticos de catálise enzimática. Esses modelos fundamentam-se no princípio de que os parâmetros físico-químicos que governam a reatividade entre dois grupamentos funcionais em uma reação intramolecular, estejam presentes também no mecanismo da ação enzimática. Os brometos de 2-(w-bromoalquiloxi)anilínio e 2-(w-bromoalquiloxi)-3-metilanilínio foram sintetizados com o objetivo de formular novos modelos miméticos. A rota sintética utilizada foi a alquilação do 2-nitrofenol e 6-nitro-2-metilfenol com dibrometos de alquila, com subseqüente hidrogenação catalítica dos nitro-compostos. As reações de ciclização das anilinas foram acompanhadas por espectroscopia de UV/Vis, em meio aquoso (solução de hidróxido de sódio 10-3 M) e em solventes orgânicos (metanol, etanol e acetonitrila, e misturados na proporção 1 : 1 com água), monitorando o aparecimento do produto ciclizado. Os resultados cinéticos indicam que as reações de ciclização dos compostos com o grupo metila são aproximadamente 3 e 14 vezes mais rápidas, para os anéis de 8 e 7 membros respectivamente, comparadas às ciclizações dos compostos sem metila. Cálculos de modelagem molecular sustentam o mecanismo via substituição nucleofílica intramolecular
Jubilee of the discovery of mauve and of the fundation of the coal-tar colour industry / by Sir W. H. Perkin,... ; edited by Raphael Meldola,... Arthur G. Green,... John Cannel Cain,...
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