268 research outputs found
Branislav Nusic and X-rays in the story “Roentgen’s Photography”
No full textIntroduction. Shortly after the discovery of X-rays, their practical
application in the clinical practice became the object of interest of many
non-medical individuals. One of them was the famous Serbian writer,
Branislav Nusic. This paper presents the life and work of Branislav Nusic,
as well as his article: ?Roentgen?s Photography? which was published in the
journal ?Politics? (July 8, 1906; N? 892, p. 3), under the alias Ben Akiba,
in the Cyrillic script. The life and work of Branislav Nusic. Alchiviadi
Nu?a, later Branislav Nusic (1864 - 1938) was a great Serbian literate,
playwright, journalist, photographer, politician, diplomat, member of the
Serbian Royal Academy, President of the Association of Yugoslav Playwrights,
manager of the theaters in Belgrade, Novi Sad, Skopje and Sarajevo, and a
military volunteer in the Serbian - Bulgarian war (1885). ?Roentgen?s
Photography?. The author wrote this text in his own way, the only way he
could and knew, vividly and wittily. He knew about the great power and
strength of X-ray radiation, and he wrote of his knowledge in this short
story. Without Branislav Nusic, the history of Serbian radiology would be
poorer for not seeing the X-rays by the eyes of an educated, intelligent
and, above all, humorous writer. Conclusion. Branislav Nusic, alongside
Nikola Tesla, Mihajlo Pupin Idvorski, Dr. Abraham Vinaver, and all past and
present Serbian radiologists, has become an essential and memorable link in
the chain of the history of the Serbian radiology.</jats:p
Nine hundred fifteenth (915th) by Branislav Nušić
No full textStudying the three components of a literary work Nine hundred fifteenth by Branislav Nušić - historical, narrative and religious - the author determines it as a historical epic novel. The retreat of the Serbian army and people trough Kosovo and Albania in 1915 caused by the invasion of the Austro-Hungarian army, which is the subject of this work, is one of the most tragic events in Serbian history. For its historical reliability, interesting and exciting storytelling, profound and multiple human messages - according to the author - this novel deserves to be ranked within the best Serbian historical novels
Possible changes of endoglin expression in endothelial cells.
No full textCharles University, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Doctoral Degree Program: Pharmacology and Toxicology Candidate: Mgr. Katarína Tripská Supervisor: prof. PharmDr. Petr Nachtigal, Ph.D. Title of Doctoral Thesis: Possible changes of endoglin expression in endothelial cells Endoglin (Eng) is a co-receptor for ligands of the Transforming Growth Factor β superfamily. Multiple studies have demonstrated that Eng is associated with metabolic syndrome-related pathological conditions, such as hypercholesterolemia, hyperglycemia, hypertension, or obesity. However, the exact role of Eng in these pathologies is still unknown. Therefore, the main purpose of this thesis was to elucidate and summarize the role of membrane and soluble Eng in the selected pathologies associated with metabolic syndrome. We demonstrated that soluble Eng (sEng) levels, together with plasma lipids and markers of inflammation, were reduced after every lipoprotein apheresis in patients with familial hypercholesterolemia. This result, in combination with knowledge acquired by the review article, indicates that increased sEng levels are associated with cardiometabolic disorders. Regarding the role of membrane Eng, we showed that blockage of Eng expression by TRC105 results in a decrease...Univerzita Karlova, Farmaceutická fakulta v Hradci Králové Katedra biologických a lékařských věd Doktorský študijný program: Farmakológia a toxikológia Kandidát: Mgr. Katarína Tripská Školiteľ: prof. PharmDr. Petr Nachtigal, Ph.D. Názov dizertačnej práce: Možné zmeny expresie endoglínu v endotelových bunkách Endoglín (Eng) je ko-receptor pre ligandy zo superrodiny transformujúceho rastového faktora β. Viaceré štúdie preukázali, že Eng je spojený s patologickými stavmi súvisiacimi s metabolickým syndrómom, ako sú hypercholesterolémia, hyperglykémia, hypertenzia alebo obezita. Avšak presná úloha Eng pri týchto patologických stavoch stále nie je známa. Preto bolo hlavným cieľom tejto práce objasniť a zhrnúť úlohu membránového a solubilného Eng vo vybraných patologických stavoch spojených s metabolickým syndrómom. Preukázali sme, že hladiny solubilného Eng (sEng), spolu s plazmatickými lipidmi a markermi zápalu, sa po každej aferéze lipoproteínov znížili u pacientov s familiárnou hypercholesterolémiou. Tento výsledok v kombinácii s poznatkami získanými v prehľadovom článku naznačuje, že zvýšené hladiny sEng súvisia s kardiometabolickými ochoreniami. Pokiaľ ide o úlohu membránového Eng, ukázali sme, že blokovanie expresie Eng pomocou TRC105, má za následok zníženú hypercholesterolémiou- a...Department of Biological and Medical SciencesKatedra biologických a lékařských vědFaculty of Pharmacy in Hradec KrálovéFarmaceutická fakulta v Hradci Králov
Possibilities of influence of cardiovascular risk markers with a diet enriched with amaranth flour
No full textUniverzita Karlova v Praze 1. lékařská fakulta Abstrakt dizertační práce Možnosti ovlivnění markerů kardiovaskulárního rizika stravou obohacenou amarantovou moukou PharmDr. Zdeněk Chmelík Praha 2022 Abstract (EN) Introduction: Diet suitable for lipid metabolism disorders should not increase the total and LDL cholesterol, and ideally should assist in its lowering. Analysis of literary sources suggest that amaranth can meet these properties. Aim: The execution of literary investigation of the issue and experimental verification of lipid- lowering effect of amaranth flour in laboratory conditions. Methods: 50 (Experiment 1) or 40 (Experiment 2) The mice were divided into five (Experiment 1) or four (Experiment 2) groups fed by control mixture (C), high-energy diet (HED), high- energy diet with amaranth (HED+A) and in Experiment 1, by high-energy diet with amaranth flour and simvastatin (HED+A+S) or only with simvastatin (HED+S), and in Experiment 2 a by high-energy diet with squalene (HED+S). Weight gains were measured and TC, LDL and HDL cholesterol determined. Results: Feeding of HED diets resulted in a statistically significant increase in the TC cholesterol by 81% (Experiment 1) or 125% (Experiment 2), LDL cholesterol of 612% (Experiment 1) or 304% (Experiment 2) and a decrease in HDL cholesterol by 8.4%...Univerzita Karlova v Praze 1. lékařská fakulta Abstrakt dizertační práce Možnosti ovlivnění markerů kardiovaskulárního rizika stravou obohacenou amarantovou moukou PharmDr. Zdeněk Chmelík Praha 2022 Abstrakt (CZ) Úvod: Dieta vhodná u poruch metabolismu lipidů by neměla zvyšovat celkový a LDL cholesterol a ideálně by měla napomáhat k jeho snižování. Analýza literárních zdrojů naznačuje, že amarant může tyto vlastnosti splňovat. Cíle práce: Provedení literárního šetření dané problematiky a experimentální ověření literaturou avizovaného hypolipidemického působení amarantu v laboratorních podmínkách. Metodika: 50 (Pokus 1) respektive 40 (Pokus 2) myší bylo rozděleno do pěti (Pokus 1) respektive čtyř (Pokus 2) skupin krmených kontrolní směsí (C), vysokoenergetickou dietou (HED), vysokoenergetickou dietou s amarantem (HED+A) a v Pokusu 1 dále vysokoenergetickou dietou s amarantovou moukou a simvastatinem (HED+A+S) či pouze se simvastatinem (HED+S) a v Pokusu 2 vysokoenergetickou dietou se skvalenem (HED+S). Myším byly měřeny hmotnostní přírůstky a stanoven celkový (TC), LDL a HDL cholesterol. Výsledky: Zkrmovaní HED diety vedlo ke statisticky významnému zvýšení TC cholesterolu o 81 % (Pokus 1) respektive o 125 % (Pokus 2), LDL cholesterolu o 612 % (Pokus 1) respektive 304 % (Pokus 2) a poklesu HDL cholesterolu o...3rd Department of Medicine - Department of Endocrinology and Metabolism First Faculty of Medicine Charles University and General University Hospital in PragueIII. interní klinika - klinika endokrinologie a metabolismu 1. LF UK a VFNFirst Faculty of Medicine1. lékařská fakult
Pharmacological Influence on Atherogenesis in Experimental Animal Models of Atherosclerosis
No full textCharles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Jana Rathouská Supervisor: Doc. PharmDr. Petr Nachtigal, Ph.D. Title of Doctoral Thesis: Pharmacological influence on atherogenesis in experimental animal models of atherosclerosis Atherosclerosis is a slow inflammatory process in arterial walls which is, as a part of cardiovascular diseases, the main source of morbidity and mortality in developed countries. However, searching for the possibilities of atherosclerosis treatment requires detailed knowledge of pathogenesis of the disease itself. The use of mouse models offers one of the possibilities of studying the pathogenesis of atherosclerosis, which enables a number of interventions that would not be acceptable in human medicine. By using the high content lipid diet, we are able to induce the changes of lipid spectrum in mice. Moreover, if a targeted genetic manipulation is used, one can reach considerably advanced plaques in a relatively short time period. It is also possible to interfere in the process of atherogenesis in mouse models by using some hypolipidemic drugs, for example from the statin group that were represented in our studies by atorvastatin. By observing the vessel's reactivity to atorvastatin dosage,..
Critical regionalism in the work of architect Branislav Mitrovic
No full textIn the Serbian architecture from the end of the twentieth and at the beginning of the twenty-first century, Branislav Mitrovic (1948) distinguished himself as the most successful author of the whole orientation, as opponent of globalization uniformity and widespread conservatism. Overall, his work links the ideas of late modern and critical regionalism as the direction of the world postmodern architecture. Filled with historical reminiscences and complex meanings, rarely built out of context, it has a signified significance in contemporary post-Yugoslav architecture, derived from universalist sterility. Mitrovic's critical regionalism does not possess the eclectic features of fashionable regionalism, but is based on the selection of the best historical traits of the Balkan-Mediterranean climate and their transfer to modernity. Traditional classical and folklore motifs succesfully revives with new materials, while regulating the spatial matrix on the most functional principles
Pharmacological Influence on Atherogenesis in Experimental Animal Models of Atherosclerosis
No full textCharles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Jana Rathouská Supervisor: Doc. PharmDr. Petr Nachtigal, Ph.D. Title of Doctoral Thesis: Pharmacological influence on atherogenesis in experimental animal models of atherosclerosis Atherosclerosis is a slow inflammatory process in arterial walls which is, as a part of cardiovascular diseases, the main source of morbidity and mortality in developed countries. However, searching for the possibilities of atherosclerosis treatment requires detailed knowledge of pathogenesis of the disease itself. The use of mouse models offers one of the possibilities of studying the pathogenesis of atherosclerosis, which enables a number of interventions that would not be acceptable in human medicine. By using the high content lipid diet, we are able to induce the changes of lipid spectrum in mice. Moreover, if a targeted genetic manipulation is used, one can reach considerably advanced plaques in a relatively short time period. It is also possible to interfere in the process of atherogenesis in mouse models by using some hypolipidemic drugs, for example from the statin group that were represented in our studies by atorvastatin. By observing the vessel's reactivity to atorvastatin dosage,..
Actor as a co-author
No full textDiplomová práce se zabývá tématem herce jako spoluautora, možností autorského vkladu herce v inscenaci a hranicemi tohoto autorství. Celá problematika diplomové práce se vztahuje k autorskému magisterskému projektu Proměním se v zajíce se zármutkem a obrovskou opatrností. Obsahem první části diplomové práce je schopnost kolektivní spolupráce skupiny Gob Squad. V popisu jejich práce reflektuji své tvůrčí zkušenosti. Ve druhé části se zaměřuji na postup Anny Klimešové a kolektivu u zkoušení inscenace Proměním se v zajíce se zármutkem a obrovskou opatrností. Třetí část řeší téma herce jako spoluautora v souvislosti s výukou na katedře alternativního a loutkového divadla a jejího vlivu na mě, jako na herce a tvůrce.This master thesis focuses on the actor as a co-author, the possibilities of actor’s involvement as an author in the play and boundaries of the authorship. The research problem of the master thesis is tied to the master project I shall go into a hare with sorrow and such mickle care. The first part of the master thesis is focused on the collective ability of cooperation of the God Squad group. In their work I reflect my creative experiences. In the second part I focus on the progress of Anna Klimesova and the group while rehearsing the play I shall go into a hare with sorrow and such mickle care. The topic of the third part is the actor as a co-author in connection to learning on the department of alternative and puppet theatre and its influence on me as an actor and a creator
Process of motional abilities for under 16 ice hockey players in preliminary term
No full textTitle: Process of motional abilities for under 16 ice hockey players in preliminary term Author: Bc. Branislav Lobotka Supervisor: doc. PhDr. Jiří Suchý, Ph.D. Objective: The aim of this thesis was to design and implement a training program for development of motor skills of junior ice hockey players and it's subsequent verification in practice during preparation period 2011/2012. This thesis is based and builds on author's Bachelor thesis, in which the author analysed fitness preparation of juniors in preparation period 2010/2011. In the thesis are both fitness programs compared and analysed. As for scientific research, the author worked with hockey team HK Dukla Trencin. Conclusions and hypothesis are listed in the conclusion of the thesis. Methods: In thesis was used method of research, the method of observation, methods of literary sources, method of interview and method of measurement and testing. Results: The obtained results should form a basis for further development of fitness plans for junior ice hockey players' preparation periods. Key words: ice-hockey, athletic phase, motional abilities, U16 ice-hockey players, training, tests
Rozvoj pohybových schopností dorostenců - hráčů ledního hokeje v přípravném období
No full textTitle: Process of motional abilities for under 16 ice hockey players in preliminary term Author: Bc. Branislav Lobotka Supervisor: doc. PhDr. Jiří Suchý, Ph.D. Objective: The aim of this thesis was to design and implement a training program for development of motor skills of junior ice hockey players and it's subsequent verification in practice during preparation period 2011/2012. This thesis is based and builds on author's Bachelor thesis, in which the author analysed fitness preparation of juniors in preparation period 2010/2011. In the thesis are both fitness programs compared and analysed. As for scientific research, the author worked with hockey team HK Dukla Trencin. Conclusions and hypothesis are listed in the conclusion of the thesis. Methods: In thesis was used method of research, the method of observation, methods of literary sources, method of interview and method of measurement and testing. Results: The obtained results should form a basis for further development of fitness plans for junior ice hockey players' preparation periods. Key words: ice-hockey, athletic phase, motional abilities, U16 ice-hockey players, training, tests.Názov: Rozvoj pohybových schopností dorastencov v ľadovom hokeji v prípravnom období. Spracoval: Bc. Branislav Lobotka Vedúci práce: doc. PhDr. Jiří Suchý, Ph.D. Cieľ: Cieľom diplomovej práce bolo zostavenie a realizácia tréningového programu na rozvoj pohybových schopností hráčov ľadového hokeja vekovej kategórie dorastencov a jeho následné overenie v praxi v prípravnom období 2011/2012. Diplomová práca sa opiera a nadväzuje na autorovu bakalársku prácu, v ktorej autor analyzoval kondičnú prípravu dorastencov v prípravnom období 2010/2011. V diplomovej práci sú obe kondičné prípravy uvedených období porovnané a analyzované. Pre vedecký výskum autor pracoval s hokejovým družstvom HK Dukla Trenčín. Zistené závery a hypotézy sú uvedené v závere práce. Metódy: V diplomovej práci je použitá metóda výskumu, metóda pozorovania, metóda štúdia literárnych prameňov, metóda rozhovoru, metóda merania a testovania. Výsledky: Výsledky, ktoré získame, by mali tvoriť podklad pre ďalšiu tvorbu tréningových plánov pre prípravné obdobie dorastencov ľadového hokeja. Kľúčové slová: ľadový hokej, kondičná príprava, pohybové schopnosti, dorast, tréning, motorické testy.Pedagogika, psychologie a didaktikaFakulta tělesné výchovy a sportuFaculty of Physical Education and Spor
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