160,984 research outputs found
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Larry O. Spencer, Conference Author Presentation
No full textGen. Larry O. Spencer, USAF (Ret.), author of Dark Horse: A Journey from the Horseshoe to the Pentago
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Structural and functional studies of Malassezia sympodialis-derived allergens
No full textAtopic eczema (AE) is a chronic inflammatory skin disease characterised by pruritic (itchy) skin lesions. The pathogenic mechanisms underlying AE are still unclear, although several factors such as genetic predisposition, a dysfunctional skin barrier, exposure to environmental allergens and skin colonisation with microorganisms appear to be of importance. Malassezia sympodialis is a yeast which is part of our normal cutaneous flora. Approximately 50% of adult AE patients have serum IgE specific for M. sympodialis allergens or display immediate-type skin reactions against crude extracts of this yeast, while such reactivity is rarely observed in other allergic diseases, indicating that sensitization to this yeast is associated with AE. Ten allergens from M. sympodialis have been cloned to date, designated Mala s 1 and Mala s 5-13. Six of these exhibit sequence homology to known proteins whereas four do not. The aim of this thesis has been to gain knowledge of host-microbe interactions of allergens from M. sympodialis in the pathogenic mechanisms of AE and in healthy individuals. This has been accomplished by studying structural properties and cellular interactions, with a special focus on the two allergens Mala s 1 and Mala s 11.Mala s 1 is a major allergen mainly localized in the yeast cell wall and exposed on the cell surface. Interestingly, Mala s 1 does not exhibit any significant sequence homology to known proteins. We have solved the crystal structure of Mala s 1 by singlewavelength anomalous dispersion techniques using selenomethionine-substituted Mala s 1. Mala s 1 folds into a six-fold beta-propeller, a novel fold among allergens. The putative active site of Mala s 1 overlaps structurally with putative active sites in potential homologues, Q4P4P8 and Tri 14, from the plant parasites Ustilago maydis and Gibberella zeae, respectively. This resemblance suggests that Mala s 1 and the parasite proteins may have similar functions. In addition, we demonstrate that Mala s 1 binds to phosphatidylinositol (PtdIns) (3)-phosphate (P), PtdIns(4)P, and PtdIns(5)P, lipids possibly playing a role in the localization of Mala s 1 to the cell surface.Mala s 11 displays a high degree of sequence homology to human manganese superoxide dismutase (hMnSOD). In AE patients sensitized to M. sympodialis, hMnSOD can elicit positive skin prick tests or atopy patch tests along with binding IgE, suggesting an autoimmune response. We report that Mala s 11 is able to inhibit IgE-binding to hMnSOD and vice versa, indicating that these two homologues share common IgE epitopes. We have also identified residues possibly involved in such cross-reactivity. In addition, we compared the influence of Mala s 11 and hMnSOD on human dendritic antigen presenting cells. Whereas rhMnSOD did not affect the phenotype of monocytederived dendritic cells (DCs), rMala s 11 up-regulated maturation markers and induced significantly higher levels of inflammatory cytokines in the culture supernatants. This suggests that DCs from healthy individuals possess the ability to distinguish between Mala s 11 and hMnSOD despite their high homology. Whether this is also the case for DCs in AE patients remains to be clarified.In summary, we have determined a novel three dimensional structure not previously demonstrated among allergens. We demonstrate the ability of DCs to distinguish between proteins with high sequence homology and we provide a structural basis underlying the autoimmune response to hMnSOD in AE based on IgE-mediated cross-reactivity.List of scientific papersI. Vilhelmsson M, Hallberg BM, Rasool O, Zargari A, Scheynius A, Achour A (2006). "Crystallization and preliminary crystallographic study of the yeast Malassezia sympodialis allergen Mala s 1." Acta Crystallogr Sect F Struct Biol Cryst Commun 62(Pt 2): 97-9. Epub 2006 Jan 27 https://pubmed.ncbi.nlm.nih.gov/16511273II. Vilhelmsson M, Zargari A, Crameri R, Rasool O, Achour A, Scheynius A, Hallberg BM (2007). "Crystal structure of the major Malassezia sympodialis allergen Mala s 1 reveals a beta-propeller fold: a novel fold among allergens." J Mol Biol 369(4): 1079-86. Epub 2007 Apr 12 https://pubmed.ncbi.nlm.nih.gov/17481656III. Vilhelmsson M, Johansson C, Jacobsson-Ekman G, Crameri R, Zargari A, Scheynius A (2007). "The Malassezia sympodialis allergen Mala s 11 induces human dendritic cell maturation, in contrast to its human homologue manganese superoxide dismutase." Int Arch Allergy Immunol 143(2): 155-62. Epub 2007 Jan 26 https://pubmed.ncbi.nlm.nih.gov/17259733IV. Vilhelmsson M, Glaser AG, Badia Martinez D, Schmidt M, Johansson C, Rhyner C, Berndt KD, Scheynius A, Crameri R, Achour A, Zargari A (2008). "Mutational analysis of amino acid residues involved in IgE-mediated cross-reactivity between the Malassezia sympodialis allergen Mala s 11 and its human homologue manganese superoxide dismutase." (Submitted)</p
Author Under Sail The Imagination of Jack London, 1902-1907
No full textIn this second volume of Author Under Sail Jay Williams investigates the life of Jack London as a professional writer at the turn of the 1900s, as his publications spanned The Call of the Wild to The Iron Heel and The Road. While documenting key life events, especially his rising fame, this biography explores London's necessity to illustrate the inner workings of his own vast imagination through his socialist essays and fiction.Cover -- Title Page -- Copyright Page -- Contents -- Acknowledgments -- Introduction -- 1. Howl, O Heav'nly Muse! -- 2. Jesus in the Theater of Socialism -- 3. Jack London's Place in American Literature -- 4. Theater of War, Theater at Home -- 5. Revolution, Evolution, and the Scene of Writing -- 6. The Jack London Show Goes on the Road -- 7. Red Atavisms and Revolution -- 8. Earthquake Apocalypse and Building the City, Boat, and House Beautiful -- 9. The Future of Socialism and the Death of the Individual -- 10. The Road Never Ends -- Notes -- Bibliography -- IndexIn this second volume of Author Under Sail Jay Williams investigates the life of Jack London as a professional writer at the turn of the 1900s, as his publications spanned The Call of the Wild to The Iron Heel and The Road. While documenting key life events, especially his rising fame, this biography explores London's necessity to illustrate the inner workings of his own vast imagination through his socialist essays and fiction.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
اسلم کولسری کی غزل:بیان و بدیع کے تناظر میں: ASLAM KOLSARY’S GHAZAL IN THE LIGHT OF BIAN-O-BADIE
No full textAslam kolsari is new significant and potentially well-known personality for contributing to modern Urdu ghazal. Being a mindful and multidimensional literary figure he has specific fame in poetry. A distinguish diction in poetry is individuality specifically connected with his name. His ghazal contains all attributes of Research and criticism. Communication of an ordinary concept in his poetry is reflection of Aslam kolasri. In this article the author has explored how poetic characteristics distinguished Aslam kolsari
Self-similar regimes in Unstably Stratified Homogeneous Turbulence
No full textUnstably stratified homogeneous turbulence develops at late time a self-similar dynamics characterized by an exponential growth of turbulent quantities. It is believed from recent theoretical studies that different growth rates are possible, depending on the initial distribution of energy at large scales. In order to confirm these predictions, we run both highly resolved direct numerical simulations and a spectral model based on an eddy-damped quasi-normal closure. In addition to confirming the influence of initial conditions, our study sheds light on the anisotropic structures of the self-similar regimes
Letter from E. O. Patterson to Secretary of the Interior
No full textLetter from E. O. Patterson to Secretary of the Interior on automobile fees in the park
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