273 research outputs found
The colonial ascidian fauna of Fiordland, New Zealand, with a description of two new species
No full textFigure 4. Botrylloides leachii (NIWA 4998): (A) Zooid; (B1, B2) parietal and mesial sides of the stomach; (C) ventral side of a zooid showing relative position of gonads. Scale bars: A, C 1 mm; B 0.5 mm.Published as part of Page, M.J., Willis, T.J. & Handley, S.J., 2014, The colonial ascidian fauna of Fiordland, New Zealand, with a description of two new species, pp. 1653-1688 in Journal of Natural History (J. Nat. Hist.) 48 (27-28) on page 1659, DOI: 10.1080/00222933.2014.896487, http://zenodo.org/record/519387
Characterization of active layer water contents in the McMurdo Sound region, Antarctica
No full textThe liquid soil water contents in the seasonally thawed layer (active layer) were characterized from seven soil climate monitoring sites - four coastal sites from south to north (Minna Bluff, Scott Base, Marble Point and Granite Harbour), and inland sites from low to high altitude (Wright Valley, Victoria Valley and Mount Fleming). Mean water contents ranged from 0.013 m³ m⁻³ near the surface at Victoria Valley to 0.013 m³ m⁻³ near the ice-cemented layer at Granite Harbour. The coastal sites have greater soil water contents than the McMurdo Dry Valley and Mount Fleming sites, and moisture contents increase with depth in the active layer. The Wright Valley site receives very little infiltration from snowmelt, with none in most years. All other sites, except Mount Fleming, received between one and four wetting events per summer, and infiltrated water moved to greater depths (≈ 10–25 cm). The Scott Base and Granite Harbour sites are on sloping ground and receive a subsurface flow of water along the ice-cemented permafrost. Our findings indicate that water contents are low with very little recharge, are greatly influenced by the local microclimate and topography, and show no significant increasing or decreasing trend over 10 years of monitoring
Review of George Eliot\u27s Midlands: Passion in Exile
No full textVarious biographies and critical studies argue that Mary Ann or Marian Evans\u27s formative years in the Midlands influenced George Eliot\u27s art. They do so by explaining that memories of Robert Evans contributed to George Eliot\u27s conceptions of Adam Bede and Caleb Garth, that Cheverel Manor is Arbury Hall, that Amos Barton is largely based on the Rev. John Gwyther, the curate of Chilvers Coton whom Mary Ann knew as a child, that a good deal of autobiographical material went into the creation of Maggie Tulliver, and so on.
Is there a need, then, for Graham Handley\u27s George Eliot\u27s Midlands when at least many of these paths linking childhood, adolescence and fiction are so well trodden? The answer is yes, because this study explores those paths thoroughly and in a lively and readable way. In ten chapters, not counting the introduction and brief conclusion, the study analyses when and, more interestingly, how the Midlands of the author\u27s youth is at once projected and altered in all the novels and stories, except, of course, Romola, Daniel Deronda and The Lifted Veil.
Handley\u27s principal argument is that \u27George Eliot\u27s art derives from the personal and intellectual affiliations of her Midland years\u27 (12), and so he necessarily rehearses the sort of biographical information referred to above. He collects the latter from various sources, and makes one or two emendations along the way. For instance, Gordon Haight identified the prototype for Caterina Sarti as Sarah Shilton and said that she was nine years old when Sir Roger Newdigate\u27s nephew, \u27the impossible Captain Wybrow,\u27 married (cf. George Eliot 221). Quoting directly from Lady Newdigate-Newdegate\u27s The Cheverels of Cheverel Manor (1898), Handley quietly corrects Haight by referring to Sally Shilton, adding that she \u27was eleven years old at the time of the story\u27s action\u27 (52-4). And it appears that Haight was also wrong in saying that the Old Hall described in The Mill on the Floss is based on recollections of St. Mary\u27s Hall in Coventry: \u27in fact there was Gainsborough\u27s Old Hall, which George Eliot, despite the brevity of her visit, certainly knew about\u27 (72) - although here (as in a few other places, too) no authority is cited for saying so
Home Waters: A Year of Recompenses on the Provo River
No full textHerman Melville begins Moby Dick by noting the way humans seem almost magnetically attracted to water. There is magic in it, he writes. Take almost any path you please, and ten to one it carries you down in a dale, and leaves you there by a pool in the stream. George Handley would, no doubt, agree with this observation. His Home Waters: A Year of Recompenses on the Provo River is a gentle, slow, and deeply thoughtful book built on this special human relationship with water. Handley uses the Provo River as the locus for a series of contemplations on what it means to be a friend, father, husband, son, brother, grandson, and great-great-grandson in a particular landscape, as well as within a particular religion and community. But in the process of exploring this very specific river from its headwaters to its arrival at Utah Lake, Handley meanders through some unexpected tributaries. In the prologue to the book, Handley writes that whenever I sat down to write about the watershed, I found myself increasingly unable to separate place from story, outdoor recreation from ecological and spiritual restoration, the present from the past, and, even against my will, the historical from the personal. The way those side channels become tangled is both the beauty and the strength of this book.
I thoroughly enjoyed this book, but like most reminiscences, Home Waters occasionally suffers from a little too much navel-gazing. And like a lot of first books, sometimes it bites off more than it can chew. But these relatively minor problems are a small price to pay for a book that consistently offers refreshing insights and new ways of thinking about the world. Handley does not write the boisterous and strident prose of Edward Abbey, but he is always readable and reasonable. Readers who cherish the works of Wallace Stegner, Terry Tempest Williams, or Wendell Berry will definitely enjoy Home Waters and are likely to find a new author to watch. And readers who want to know what a Mormon environmentalist looks like need look no further
Speed math for kids: helping children achieve their full potential
No full textPopular Australian author and inspirational teacher, Bill Handley, has developed and, over the years, refined methods of teaching mathematics and learning strategies that have achieved amazing results. His best-selling book, Speed Mathematics convinced readers that people who excel at maths use better strategies and are not necessarily more intelligent. This book contains additional methods and applications based on the strategies taught in Speed Mathematics that make the principles clearer, encourage creative thought, and are just plain fun. The book was written for young people but people of any age will enjoy it. The book has notes throughout for parents and teachers. By following his innovative approach you will have kids playing with numbers, performing lightning quick calculations and, most of all, having fun! Bill claims: 'If you are good at maths, people think you are intelligent. People will treat you like you are a genius. Your teachers and your friends will treat you differently. You will even think differently about yourself'. The emphasis in this book is on playing with mathematics. Enjoy it. Show off what you learn and make mathematics your favourite subject
The imaginary world of the casino: the relationship between architecture and the casino building type
No full textThe objective of this research report is to explore and learn from the world wide casino building type. The intention is to provide the 'essence' of casino design as a basis to encourage innovative, fresh interpretations for new casino designs. That is, can casino architecture, regardless of American or European stereotyping, be traced back to single unifying themes or 'laws' which can be constructed into useful design tools for architects?
The scope of the report are those casinos of both versions, European and American, from the nineteenth century to today, which are outstandingly successful in terms of profit and in their ability to attract the tourist/visitor (ie. patrons that are not professional gamblers).
I conclude that by investigating the very different world of the casino some important fundamental 'laws' of casino design were identified. These have been formulated into a series of guidelines which can now be interpreted and reinforced by architects aiming to design a successful casino
Some Refinements of Hilbert-Pachpatte type integral Inequalities
No full textIn this paper, we obtain an extension of a multivariable integral inequality of Hilbert-Pachpatte type. By specializing the upper estimate functions in the hypothesis and the parameters, we obtain many special cases
Theorising disability: Beyond common sense
No full textThis article seeks to introduce the topic of disability to political theory via a discussion of some of the literature produced by disability theorists. The author argues that these more radical approaches conceptualise disability in ways that conflict with ‘common-sense’ notions of disability that tend to underpin political theoretical considerations of the topic. Furthermore, the author suggests that these more radical conceptualisations have profound implications for current debates on social justice, equality and citizenship that highlight the extent to which these notions are also currently underpinned by ‘common-sense’ notions of ‘normality’
Generation of a large animal model of Fragile X Syndrome for therapeutic testing
No full textFragile X syndrome (FXS) is an X-linked neurodevelopmental condition. For most FXS
individuals, symptoms result from hypermethylation of an expanded CGG repeat in the 5’
UTR of the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene, leading to
transcriptional suppression and a lack of fragile X messenger ribonucleoprotein (FMRP).
There is no cure for FXS, with available therapies addressing symptom management.
Animal models of FXS have been used to test the efficacy of potential treatments; the most
commonly used is the FMR1 knockout mouse. However, despite promising results in the
mouse model, these treatments fail in human clinical trials. This is due to the low predictive
validity of mouse models for neurological conditions, particularly differences in size and
structure of human and mouse brains. This thesis describes the production and preliminary
characterisation of an ovine FXS model to address the treatment translation gap. Sheep are an
ideal human disease model with comparable brain size and morphology to humans, large
body mass and extended life span. CRISPR guides targeting the ovine FMR1 gene were first
evaluated in cultured sheep cells, demonstrating remarkable editing efficacy at 82%.
To produce the FXS sheep, South Australian merino embryos were edited using CRISPR via
nuclear injection of Cas9-guide RNA complex, resulting in two founder animals. The first
FXS knockout sheep was a ewe carrying two separately edited alleles of FMR1, resulting in
no FMRP. This founder showed preliminary evidence of FXS phenotypes, including
hyperflexible joints and increased levels of Aβ peptides in plasma. The second founder, a
male, carries a large hemizygous deletion (2.7 kb) in FMR1 and no detectable FMRP. This
ram has been used for breeding to expand the flock.
Single-cell RNA sequencing performed on white blood cells from the FXS founders revealed
changes in biochemical pathways and identified potential biomarkers for FXS. Lastly,
towards the development of a therapy, an AAV-FMR1 vector was produced and trialled in an
FMR1-KO isogenic fibroblast cell line, rescuing FMRP expression. It is anticipated that, in
the near future, this vector will be delivered into the brains of young FXS lambs in an attempt
to treat FXS
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