494 research outputs found
Functional Characterisation of Alpha-Galactosidase A Mutations as a Basis for a New Classification System in Fabry Disease
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The study has been supported partially by an unrestricted scientific grant from Shire Human Genetic Therapies (Germany
High-temperature fiber-optic Fabry-Perot interferometric sensors
No full textA photonic crystal fiber (PCF) based high-temperature fiber-optic sensor is proposed and experimentally demonstrated. The sensor head is a Fabry-Perot cavity manufactured with a short section of endless single-mode photonic crystal fiber (ESM PCF). The interferometric spectrum of the Fabry-Perot interferometer is collected by a charge coupled device linear array based micro spectrometer. A high-resolution demodulation algorithm is used to interrogate the peak wavelengths. Experimental results show that the temperature range of 1200 degrees C and the temperature resolution of 1 degrees C are achieved. (C) 2015 AIP Publishing LLC
Wearable Fabry-Pérot Antenna
No full textA wearable version of Fabry-Pérot antenna is presented. This is a simple way of designing a medium-To high-gain antenna with low back radiation. The study of the effect of antenna bending in the performances is presented. Besides, the replacement of a superstrate layer by a metallic frequency selective surface is proposed. In this way, there is no need of finding a specific material and thickness for a targeted gain and frequency. Experimental validation confirms the viability of this design.Accepted Author ManuscriptTera-Hertz Sensin
Fabry-Perot Interferometer Measurement of the Temperature and Wind at F Layer Heights
No full textA thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy in the Division of Theoretical and Space Physics, School of Physical Sciences, La Trobe University, Victoria, Australia.</p
Wide-angle spectral imaging using a Fabry-Perot interferometer
No full textWe show that wide-angle spectral imaging can be achieved with compact and cost-effective devices using Fabry-Pérot interferometers. Designs with a full field of view of 90°, in which the Fabry-Pérot interferometer is mounted either in front of an imaging lens system or behind a telecentric lens system, are presented and analysed. We show the dependency of the spectral resolution on the numerical aperture of the lens system and demonstrate its value as a design criterion.ImPhys/Imaging PhysicsApplied Science
Design of a folded, multi-pass Fabry–Perot cavity for displacement metrology
No full textWe present a folded, multi-pass cavity design for displacement measuring Fabry–Perot interferometry. The cavity length is designed to be one-quarter of the physical length needed for a typical Fabry–Perot interferometer by using a quarter-wave plate and a retroreflector. This enhances the displacement sensitivity by a factor of four, allowing for higher resolution in viewing the effects caused by mechanical motions, refractive index changes and frequency fluctuations from the laser source. Furthermore, the geometrical error motions are minimized by using a retroreflector due to its tip–tilt insensitivity. In this note, a theoretical analysis of the folded, multi-pass Fabry–Perot cavity is described and analyzed with Jones matrices in ideal and non-ideal designs.Precision and Microsystems EngineeringMechanical, Maritime and Materials Engineerin
APPLICATION OF THE FABRY-PEROT INTERFEROMETER TO SPECTRAL SORTING
No full textAuthor Institution: Princeton University ObservatoryApplication of the Fabry-Perot Interferometer to the multiplexing of Raman Spectra is made. Results will be given for some laboratory systems
The effects of ocean acidification and upwelling conditions on the growth and calcification of the red abalone (Haliotis rufescens)
No full textUpwelling events along the California coast expose invertebrates to low dissolved oxygen simultaneously with high pCO2 levels that are progressively increasing as a result of rising atmospheric CO2. These multiple stressors could potentially impact the growth and calcification of economically valuable molluscs, such as abalone. To evaluate this threat, juvenile red abalone were maintained over a 4-week period in seawater undersaturated with respect to aragonite and containing 85% dissolved oxygen, which simulated an upwelling event. Seawater conditions were then returned to ambient levels for 3 weeks to determine the ability of the abalone to recover from the potential effects of low oxygen and high pCO2 conditions. Abalone exposed to the treatment had lower shell weights and calcium content per shell than abalone in the ambient group. Shells also appeared much lighter in color following the acidification period. After both groups were returned to ambient conditions, shells of the abalone in the treatment group still weighed less and had lower calcium content than the shells of the ambient group. The amount of weight gained by the abalone during the 3-week ambient period, however, was the same for both groups, suggesting an ability to recover a normal rate of weight gain after exposure. These findings suggest that juvenile red abalone experienced decreased net calcification following exposure to high CO2 and decreased DO. Though abalone were able to recover to normal growth rates, they were not able to accelerate their net calcification to catch up to the shells weights and calcium content of the ambient group, suggesting that they may have thinner or less dense shells following each upwelling eventKeywordsIncludes bibliographical references (p. 16-19, 52-55 )Thesis (M.S.)--California State University San Marcos, 2011Committee members: Victoria Fabry (chair), Andrew Dickson, William KristanTitle from first page of PDF file (viewed Dec 12, 2011)LD729.6.S57.S3 W5855 201
Fabry-Perot interferometers
No full textThis book describes the Fabry-Perot interferometer and its variants as well as its use, optimisation and applications. The author begins with an historical perspective on the development of the instrument. Because of the quantitative uses of the device, the text tends to be mostly mathematical in its treatment. However, there is also much practical detail on the use and optimization of the Fabry-Perot interferometer and discussion of its classical uses (such as in metrology) and its contemporary applications (such as in lasers). In addition the book contains a comprehensive bibliography summarizing the extensive literature on the subject. This book will appeal both to high-resolution practitioners, such as spectroscopists, and to the laser community, since the Fabrv-Perot is not only an integral part of the laser but is also usea to characterize its optical and spectroscopic behaviour
A Metabolomic Study To Identify New Globotriaosylceramide-Related Biomarkers in the Plasma of Fabry Disease Patients
No full textFabry disease is an X-linked lysosomal
storage disorder caused
by a deficiency of the enzyme α-galactosidase A, which results
in the progressive accumulation of glycosphingolipids. In addition
to the two biomarkers, globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3), which
are routinely used for detection and high-risk screening of Fabry
disease patients, novel urinary Gb3-related isoforms/analogues
as well as newly defined lyso-Gb3 analogues in plasma and
urine from Fabry patients have recently been described by our group.
The aim of this study was to extend our recent analyses to identify
and evaluate new potential Gb3-related biomarkers in the
plasma of untreated male Fabry disease patients using a mass spectrometry
metabolomic approach. A multivariate statistical analysis revealed
five Gb3-related novel biomarkers in the plasma of male
Fabry patients. Three of these new biomarkers correspond to Gb3, which has an extra double bond on the sphingosine with C16:0,
C18:0, and C22:1 fatty acid chains. The fourth biomarker corresponds
to a mixture of two structural isomers, the first with a d16:1 sphingosine
and a C16:0 fatty acid and the second with a d18:1 sphingosine and
a C14:0 fatty acid. To our knowledge, it is the first time that a
Gb3 analogue with a d16:1 sphingosine moiety has been reported.
In addition, this Gb3 analogue was also present in its
methylated form. These biomarkers are part of a metabolic profile
that may provide insight into the pathophysiology of Fabry disease
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