1,720,981 research outputs found
COP/CHOP regimens as first line chemotherapy in primary cutaneous lymphomas: a clinical follow-up study of 98 patients.
No full textMultiple primary melanomas: analysis of 49 cases.
No full textDevelopment of multiple primary melanomas is a rare but well recognized disease, with an estimated incidence ranging from 1.75% to 8.5% in several series. The clinical, histological and epidemiological characteristics of 49 patients, identified from 2470 with histologically confirmed melanoma, are described in this study. Thirty-five of these patients had two primary melanomas, 11 had three melanomas and three had four, five and six melanomas, respectively. Diagnosis was concurrent in 22 patients (45%); in the remaining cases the median time interval between the first and second melanoma was 22.6 months and the longest interval was 21.5 years. The mean Breslow's thickness decreased significantly (P < 0.001) from the first melanoma to the second and third lesion. The multiple melanoma patients had a higher percentage of subjects over 70 years of age or with lentigo maligna melanoma than single melanoma patients. The mean follow-up time was 12 years (range 4 23 years). The 5-year survival rate from first melanoma excision (83%) does not differ from that of patients with a single melanoma. In conclusion, the presence of multiple primary melanomas does not appear to be a negative prognostic factor; our data show the importance of close follow-up in melanoma patients in order to detect not only metastases, but also subsequent primaries in their earliest phases
Rozhovor s Asunntou Verrone a Peterem Nicklem
Full text linkVe dnech 8. až 11. dubna proběhl v severoněmeckém Hannoveru druhý Festival filosofie, tentokrát na téma "Člověk – příroda – technika". Tradice pořádání filosofických festivalů vznikla před několika lety v italské Modeně a rozšířila se do několika evropských měst. Idea festivalu v sobě spojuje filosofickou konferenci a popularizační akce s přesahy do jiných oborů. Festival tak není určen k prezentaci nových vědeckých výsledků, ale spíše k hledání role filosofie ve společnosti a k prohloubení jejího vlivu na problémy dneška. Festival filosofie se tak vrací k původnímu významu tohoto slova jako oslavy. Téma festivalu "Člověk – příroda – technika" bilancuje desetileté výročí výstavy Expo 2000, jež se tehdy konala v Hannoveru. V souvislosti s touto výstavou se dostalo do popředí také téma urbanity. To znamená, že kromě celé řady přednášek pohybujících se okolo tématu strategie trvalosti, proběhlo také několik přednášek na téma architektury. Hlavním řečníkem festivalu byl známý architekt a urbanista prof. Albert Speer, ml. V následujícím textu vám přinášíme rozhovor se spoluorganizátory festivalu Asunntou Verrone a Peterem Nicklem
Rozhovor s Asunntou Verrone a Peterem Nicklem
No full textVe dnech 8. až 11. dubna proběhl v severoněmeckém Hannoveru druhý Festival filosofie, tentokrát na téma „Člověk – příroda – technika“. Tradice pořádání filosofických festivalů vznikla před několika lety v italské Modeně a rozšířila se do několika evropských měst. Idea festivalu v sobě spojuje filosofickou konferenci a popularizační akce s přesahy do jiných oborů. Festival tak není určen k prezentaci nových vědeckých výsledků, ale spíše k hledání role filosofie ve společnosti a k prohloubení jejího vlivu na problémy dneška. Festival filosofie se tak vrací k původnímu významu tohoto slova jako oslavy. Téma festivalu „Člověk – příroda – technika“ bilancuje desetileté výročí výstavy Expo 2000, jež se tehdy konala v Hannoveru. V souvislosti s touto výstavou se dostalo do popředí také téma urbanity. To znamená, že kromě celé řady přednášek pohybujících se okolo tématu strategie trvalosti, proběhlo také několik přednášek na téma architektury. Hlavním řečníkem festivalu byl známý architekt a urbanista prof. Albert Speer, ml. V následujícím textu vám přinášíme rozhovor se spoluorganizátory festivalu Asunntou Verrone a Peterem Nicklem
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Combination of etoposide, idarubicin, cyclophosphamide, vincristine, prednisone and bleomycin (VICOP-B) in the treatment of advanced cutaneous T-cell lymphoma.
No full textBACKGROUND: Response of cutaneous T-cell lymphoma (CTCL) to systemic chemotherapy is unsatisfactory: despite an initially high response rate (RR), duration is always short-lived. OBJECTIVE: To investigate the capability of a third-generation regimen including idarubicin in improving RR and response duration in CTCL patients. METHODS: Twenty-five patients with advanced CTCL (stages IIB and IV) were treated with a 12-week polychemotherapeutic regimen (VICOP-B), which foresees the use of idarubicin in association with etoposide, cyclophosphamide, vincristine, prednisone and bleomycin. RESULTS: The overall objective RR was 80% (36% complete response). The mycosis fungoides (MF) RR was 84%, with a median duration of 8.7 months. The pleomorphic-lymphoma RR was higher (100%), but the corresponding response duration was shorter (median: 3 months). No responses were documented in SÚzary syndrome. CONCLUSION: VICOP-B regimen is effective and feasible as first-line chemotherapy in advanced MF, with or without extracutaneous involvement
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