68 research outputs found
¡La UNA es una universidad que enseña y que también aprende!
Get PDFFil: Vera de Molinas, Zully C. Universidad Nacional de Asunción; Paraguay.Ante la situación planteada por la crisis sanitaria COVID-19, cada unidad académica analizó,
estudió y dispuso, establecer un periodo de transición para adoptar la modalidad virtual de los
contenidos académicos que logre dar continuidad a las clases en algunos casos y, en otros dar inicio
al año lectivo, estableciendo clases virtuales a todas las carreras. Algunas de gran exigencia práctica
decidieron retomar cuando se den las condiciones sanitarias. En este contexto, temporalmente las
facultades empezaron a migrar su contenido presencial o transición semipresencial a distancia,
totalmente al modelo virtual. Para lograr viable y operativo este objetivo, se inició un programa
especial de capacitación de todos los docentes mediante un curso virtual obligatorio, de manera de
lograr el proceso de adiestramiento de las plataformas de enseñanzas, su uso y dinámica tecnológica.
Actualmente, cincuenta por ciento de las facultades reiniciaron desde mayo sus actividades con un
modelo de educación a distancia, otras unidades académicas iniciarán a partir del mes julio. Cada facultad, según las características de sus carreras y perfiles de egreso, determinaron el plazo, proceso
y la plataforma a usar.publishedVersionFil: Vera de Molinas, Zully C. Universidad Nacional de Asunción; Paraguay
Evaluation of the Health Impact of the National Diabetes Program in Paraguay
Get PDFThe clinical evolution of a diabetic patient is linked to its compliance with nonpharmacological measures such as diet, physical activity, acquiring habits, medical controls and also with its pharmacological treatment. In different Latin American countries such as the Republic of Paraguay, there are National Programs to provide free support and treatment to the diabetic population that mostly have vulnerable social conditions. However, the impact of these government policies is not routinely evaluated. In order to establish the achievements of a state diabetes program, the present study was carried out. Methodology: This is a descriptive, cross-sectional study with an analytical stage. Results: low adherence to non-pharmacological measures such as diet and physical activity was detected. A high percentage of patients were overweight (38%) or obese (46.5%). 75% of the population enrolled in this study did not comply with the program recommendations regarding the time and frequency of physical activities, nor they complied with the minimum 6 daily meals required. Only 37% of the patients had normal levels of glycated hemoglobin and 51.3% of them had pharmacological treatment adherence. Low compliance was observed in relation to regular medical examinations (which were under free coverage by the program) that are transposed in 22% of retinal studies and 60% in 24-hour urine analysis for the early detection of complications such as retinopathy and nephropathy. Conclusion: Despite the economic and logistical efforts carried out by State programs in order to care of people with diabetes mellitus, data showed a low adherence of patients to the proposed pharmacological and non-pharmacological measures. A personalized follow-up strategy is necessary to improve treatment adherence and to obtain better therapeutic results.Fil: Rodríguez, Patricia Vera. Universidad Nacional de Asunción; ParaguayFil: Zully, Vera. Universidad Nacional de Asunción; ParaguayFil: Olga, Maciel. Universidad Nacional de Asunción; ParaguayFil: Marin, Lupe. Universidad Nacional de La Plata; ArgentinaFil: Maidana, Gladys Mabel. Universidad Nacional de La Plata; ArgentinaFil: Marin, Gina. Universidad Nacional de La Plata; ArgentinaFil: Marin, Gustavo Horacio. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentin
Advancing fast relaxation imaging to determine protein stability and folding kinetics on poly(n-isopropyl acrylamide) films
Get PDFSeveral studies have reported the use of the thermo-responsive polymer PNIPAM to capture and release cells or proteins for medical purposes; however, this assumes that PNIPAM does not perturb the stability of biomolecules. Previous analytical and spectroscopic techniques have not been able to confirm this assumption due to limitations in detection of proteins on surfaces. Additionally, protein absorption above the lower critical solution temperature of PNIPAM (32℃) is dependent on the grafting density and molecular weight of the end grafted PNIPAM. The work presented here applies a novel technique to demonstrate how protein adsorption on PNIPAM affects protein thermodynamic stability and kinetics. Fast Relaxation Imaging (FReI) was applied to quantify the folding stability and dynamics of proteins in contact with PNIPAM at varying grafting conditions categorized as brush, weakly overlapping, and mushroom regime. FReI detects protein unfolding in situ by imaging changes in fluorescence resonance energy transfer (FRET) after fast temperature perturbations. The protein used in experiments is phosphoglycerate kinase (ePGK1), which undergoes cooperative unfolding. Contrary to previously accepted notions, the melting temperature and kinetic parameters of ePGK1-FRET reveal that the weakly overlapping and mushroom regimes do in fact perturb the thermodynamic stability and kinetics of ePGK1. Similar to the protein adsorption trend, the perturbations exhibit a bell-shape dependence on the PNIPAM regimes. Additionally, this work shows that FReI can be used to confirm how biomaterials perturb proteins on polymer surfaces.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-12-01The student, Zully Mora Sierra, accepted the attached license on 2020-12-10 at 22:41.The student, Zully Mora Sierra, submitted this Thesis for approval on 2020-12-10 at 22:54.This Thesis was approved for publication on 2020-12-11 at 14:07.DSpace SAF Submission Ingestion Package generated from Vireo submission #16120 on 2021-03-04 at 16:20:59Made available in DSpace on 2021-03-05T21:42:55Z (GMT). No. of bitstreams: 2
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Previous issue date: 2020-12-11Embargo set by: Seth Robbins for item 117248
Lift date: 2023-03-05T21:43:00Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemAuthor requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Onl
Factors Associated with the Lack of Adherence to Drug Therapy in Diabetic Patients
Get PDFAccording to the World Health Organization, there are more than 347 million people living with diabetes, being one of theleading causes of death in our days. Diabetes mellitus is a chronic metabolic disorder characterized by an increase in glycemiavalues above normal, which is accompanied by late complications derived from progressive damage in kidney, retina, vessels,heart, and nervous system. The best way to avoid these complications is adherence to treatment. However, the lack of treatmentcontinuity is very frequent. This paper demonstrated that in 76% of the cases, patients with diabetes do not accomplish theprescribed treatment. The main causes of this situation are related to the patient?s habits (since diabetes has no symptoms,the patients skip doses) and to the health system (due to the lack of free drug provision, patients do not have access to thetreatment). From this data, health country authorities initiated a program to aware patients of the importance to accomplish thetreatment and provided free drug for those patientsFil: Rivas, Alba. Universidad Nacional de Asunción; ParaguayFil: Vera, Zully. Universidad Nacional de Asunción; ParaguayFil: Marin, Gustavo Horacio. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Lugo, Gladys B.. Universidad Nacional de Asunción; ParaguayFil: Domenech, María Gloria. Universidad Nacional de Asunción; ParaguayFil: Samaniego, Lourdes. Universidad Nacional de Asunción; ParaguayFil: Mastroianni, Patricia. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Maidana, Gladys Mabel. Universidad Nacional de Asunción; Paragua
Cost-Effectiveness of drug compliance in type 2 diabetes mellitus patients
Get PDFType 2 diabetes mellitus affects 15% of the population around the world, causing health complications and increasing the treatment’s costs. Being a chronic outpatient treatment disease, patient compliance is higher importance to achieve therapeutic success. The present study measure the cost effectiveness of the compliance of this disease. An observational, cross-sectional, pharmaco-economic study was performed. A National program to stimulate treatment adherence was taken as intervention stage. Compliance was measure by Morisky-Green test and details of the events in each patient's health (medication, consultations, hospitalization and concomitant treatments) were used to determinate the direct costs for Ministry of Public Health. Effectiveness was measured by percentage of glycated hemoglobin (HbA1c). The sample obtained was 55 patients, which were grouped into 31 compliant and 24 non-compliant. The costeffectiveness of compliance was 466 US / non-compliant effective patient. The cost-effectiveness of hypoglycemic drug therapy compliance is significantly lower (almost 4 times) than non-compliance. Type 2 Diabetes Mellitus patients that have no therapy adherence are not able to maintain protective levels of HbA1c. In addition, for the Ministry of Public Health, the lack of adherence requires more budget to accomplished the health goals.Fil: Maciel, Olga. Universidad Nacional de Asunción; ParaguayFil: Vera, Zully. Universidad Nacional de Asunción; ParaguayFil: Marin, Gustavo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas; ArgentinaFil: Maidana, Mabel. Universidad Nacional de Asunción; ParaguayFil: Samaniego, Lourdes. Universidad Nacional de Asunción; ParaguayFil: Lugo, Gladys. Universidad Nacional de Asunción; ParaguayFil: Mastroianni, Patricia. Universidade Estadual Paulista Julio de Mesquita Filho; Brasi
Prevalence of arterial hypertension and its risk factors in young adults of Paraguay
Get PDFEarly detection of arterial hypertension is critical for preventing the occurrence of cardiovascular diseases. A cross-sectional, observational, descriptive study was performed in order to determine the prevalence of arterial hypertension and cardiovascular risk factors among young university students in Paraguay. WHO hypertension parameters were used to classify the hypertension status. The research demonstrated that 18.6% of the students were classified in the prehypertension and 2.2% of the population had already a hypertension stage I status. 25.8% of the students had exceed the normal body mass index and 67.4% had a family history of hypertension. The values of blood pressure and family history were very unusual among youth population and in relation to similar population around the world.Fil: Lugo, Gladys B.. Universidad Nacional de Asunción; ParaguayFil: Vera de Molinas, Zully. Universidad Nacional de Asunción; ParaguayFil: Marin, Gustavo Horacio. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Samaniego, Lourdes Raquel. Universidad Nacional de Asunción; ParaguayFil: Toledo, Jonny. Universidad Nacional de Asunción; ParaguayFil: Lial, Nilsa. Universidad Nacional de Asunción; ParaguayFil: Acosta, Patricia. Universidad Nacional de Asunción; ParaguayFil: Mastroianni, Patricia. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Maidana de Larroza, Gladys M.. Universidad Nacional de Asunción; Paragua
Relación entre el control de la hemoglobina glicosilada y la frecuencia de amputación en pacientes diabéticos tipo 2 atendidos en los hospitales IESS y León Becerra - Milagro, Guayas – Ecuador 2013 – 2016
Get PDFPublicación a texto completo no autorizada por el autorDemuestra la relación entre el control de la hemoglobina glicosilada y la frecuencia de amputación en pacientes diabéticos Tipo 2 controlados con HbA1C del Hospital del IESS y del Hospital Dr. León Becerra del cantón Milagro, Guyas, Ecuador. Desarrolla una investigación cualitativa, no experimental, correlacional y transversal. La población está conformada por 290 pacientes diabéticos. Encuentra la prevalencia de esta patología en el sexo femenino en un rango de edad comprendida entre los 65 a 70 años, lo que representa el 42% de la muestra estudiada. De la misma forma, el 62% de los individuos frecuentan controles glucémicos cada tres meses, mientras que las regiones anatómicas con mayor frecuencia de amputación se dan en los dedos con un 53%. Ante aquello, el examen de la hemoglobina glicosilada permite tener el nivel promedio de glucosa durante los últimos tres meses. Establece que el pie diabético involucra los pilares neuropático, isquémico e infeccioso para determinar la decisión de amputación, de ahí que, la prueba HbA1c asegura en los pacientes diabéticos Tipo 2 la correlación del riesgo de la presencia macro y micro-vasculares sobre los exámenes tradicionales.Tesi
Factores de riesgo asociados a mortalidad por gangrena de Fournier en pacientes de cirugía Hospital II-2 Santa Rosa Piura 2006-2016
Get PDFOBJETIVO: Estudiar cuáles son los factores de riesgo asociados a mortalidad por gangrena de fournier en pacientes del departamento de cirugía del hospital II-2 santa rosa piura 2006-2016.
MATERIAL Y METODOS: Se realizó un estudio aplicado, observacional, analítico y transversal de tipo retrospectivo de análisis de datos primarios, mediante el empleo historias clínicas de pacientes diagnosticados con gangrena de fournier en el departamento de cirugía del hospital II-2 santa rosa 2006-2016.
RESULTADOS: Se encontró un total de 29 casos reportados de gangrena de fournier entre los años 2006 – 2016, de los cuales un 93.70% corresponde al sexo masculino y la edad promedio fue de 57.79 años. El tiempo de evolución y abordaje de la enfermedad fue en promedio de 2 meses. El total de casos de pacientes fallecidos a causa de esta patología fue de un 10.34%, en el aspecto terapéutico se utilizó antibiótico meropenem como monoterapia, además de solo una limpieza quirúrgica. Se encontró que solamente el nivel de sodio en el perfil de electrolitos está asociado a fallecimiento.
CONCLUSIONES: El tipo de antibióticoterapia, el número de limpieza quirúrgica y el sodio en el perfil de electrolitos están asociados a mortalidad teniendo una significancia P<0.001.OBJECTIVE: To study the risk factors associated with fournier gangrene
mortality in patients of the surgery department of hospital II-2 Santa Rosa Piura
2006-2016.
MATERIAL AND METHODS: An applied retrospective, observational,
analytical and cross-sectional study of primary data analysis was performed,
using clinical histories of patients diagnosed with fournier gangrene in the
department of surgery of hospital II-2 Santa Rosa 2006- 2016.
RESULTS: A total of 29 reported cases of fournier gangrene were found
between 2006 - 2016, of which 93.70% correspond to the male sex and the
average age was 57.79 years. The time of evolution and approach of the
disease was on average of 2 months. The total of cases of deceased patients
due to this pathology was 10.34%, in the therapeutic aspect meropenem
antibiotic was used as monotherapy, in addition to only a surgical cleaning. It
was found that only the level of sodium in the electrolyte profile is associated
with death.
CONCLUSIONS: The type of antibiotic therapy, the surgical cleaning number
and the sodium in the electrolyte profile are associated with mortality having a
significance of P <0.001.Tesi
Evaluation of compliance with good prescription practices in the children's maternal hospital in capiatá, paraguay
Get PDFThe evaluation of “Good Prescription Practices” is essential to know what are the most frequent mistakes that health’s professionals develop at prescribing a drug to their patients and quantify it these errors are associated to serious adverse reactions. Errors in medical prescriptions are a health problem that can result in patient's health damage. Each Health institution must know these errors in order to perform actions to minimize them. The objective of this work is to quantify prescription errors in the Maternal-Children hospital in Capiatá, Paraguay in order to detect the points that require improvements. Methods: It is a crosssectional study that analyse pharmacological prescriptions, and type and quantity of medical errors. Variables studied were calligraphy, legible or illegible of letter; presence or lack of signature & stamp of the doctor; presence or lack of date; paper prescription with/without letterhead or institution stamp; concentration of the pharmaceutical form; omission of the pharmaceutical form; prescription by trade name; amendments in recipes. Results: 7836 prescriptions were analysed with a total of 15429 prescribed medications. It was detected 18.25% of an illegible prescription; 0.06% lack of doctor's signature or stamp; 12% omit the date; 1% were recipes without letterhead or seal of the institution; 18.4% drug concentration not registered; 14.5% do not clarify the pharmaceutical form or quantity to be dispensed; 34.6% had error or omission in the unit of measure; 0.9% carry out the prescription with a trade name and 0.16% submit an amendment to the recipe. Conclusion: the present study reveals that Good Prescriptions Practices are poorly performed in Paraguay’s Maternal & Children Hospital. As consequence, prescription errors are frequent, mostly of them severe; and potentially patient’s health is in risk. From this knowledge, the errors are now detected and can be corrected.Fil: Flecha Galeano, Liz Paola. Universidad Nacional de Asunción; ParaguayFil: Zully, Vera. Universidad Nacional de Asunción; ParaguayFil: Marin, Gustavo Horacio. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Lugo, Gladys Beatriz. Universidad Nacional de Asunción; ParaguayFil: Samaniego, Lourdes. Universidad Nacional de Asunción; ParaguayFil: Maidana, Gladys Mabel. Universidad Nacional de Asunción; Paragua
Evaluation of the partial or total substitution of PVC and Phthalates by atoxic raw materials in the production of a conventional rubber eraser at laboratory scale
No full textCurrently the rubber erasers of the company I.D.E.A.S are made from PVC and plasticizers, these two products have harmful effects for the environment and human health, however, the performance of the product is good and the costs are low. In European markets, they implemented regulations that eliminate products that contain PVC in their composition. When wanting to reach this market, it is necessary to replace these components with others that don't have implications for the environment or represent a risk to health but keep up the same quality as PVC erasers.Actualmente los borradores de la empresa I.D.E.A.S se elaboran a partir de PVC y plastificantes, estos dos productos presentan efectos nocivos para el medio ambiente y la salud humana, sin embargo, el desempeño del producto es bueno y los costos son bajos.En los mercados europeos implementaron normativas que eliminan los productos que contengan PVC en su composición. Al querer llegar a este mercado se hace necesario reemplazar estos componentes por otros que no tengan implicaciones con el medio ambiente ni representen un riesgo a la salud pero conservando la misma calidad que tienen los borradores del PVC.I.D.E.A.
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