189,793 research outputs found

    Spatial pattern of nerve differentiation in Hydra is due to a pattern of nerve commitment

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    The pattern of nerve differentiation along the body column of Hydra was investigated. Nerve precursors in late S phase were labeled with [3H]thymidine and their distribution compared with that of newly differentiated nerves. The two distributions were found to be the same. Based on independent evidence that nerve commitment occurs in mid-to late S phase (G. Venugopal and C. David, 1981, Develop. Biol.83, 361–365) it was concluded that the pattern of nerve differentiation along the body column of Hydra is due to differences in nerve commitment in different body regions. Furthermore, the level of nerve commitment in head and foot tissue is sufficiently high to deplete stem cells in these regions as is observed

    Pheropsophus indicus Venugopal & Thomas 2019, sp. nov.

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    <i>Pheropsophus indicus</i> sp. nov. <p>(Fig. 4 B, 5 B)</p> <p> <b>Specimens examined (n=2)</b>: Holotype, labelled “ Male, India: Kerala: Palakkad (10.806420°N, 76.690174°E), Hand Picking (Wet Paddy field), 26.XI.2017, coll. M. Divya ”; Paratype, male, India: Karnataka, 2013, coll. A. Anichtchenko.</p> <p> <b>Description.</b> TLA: 15.8 mm; TW: 6.6 mm</p> <p> <b>Colour:</b> Black head, pronotum and elytra. Black spot on head wide, widest towards pronotum, broad ‘M’ shaped black spot on vertex of head with a narrow extension up to the clypeus; clypeus and labrum black; epistome, margin around the eyes, reddish yellow; maxillary and labial palpi, reddish brown; eyes grey; first four antennal segments light reddish yellow, segments 2–4 with reddish brown ring on the apical portion, segments 5–11 reddish brown; scutellum black; humeral spot pale reddish yellow; legs with coxa, trochanter, femur, tibiae and 1 st segment of tarsi, reddish yellow; rest of the tarsal segments reddish brown; claws dark brown; apex of femur with wide black spot; underside of head reddish yellow, gula well-marked with reddish brown gular suture; prothorax including the prosternum black; mesosternum black; metasternum anterior half reddish yellow and posterior half black; metepisternum black.</p> <p> <b>Head:</b> Stout, smooth, glabrous, shiny, neck wrinkled; eyes protruding, with one supraorbital setae in the mid region above eye; antennae long, reaching the middle of elytra.</p> <p> <b>Pronotum:</b> Wider than long, smooth, glabrous except for a group of minute seta lining the apical margin; basal and apical margins straight, corners of apical and basal margin rounded, anterior 3/4 th of the lateral margin convex, posterior 1/4 th straight; deep median furrow; lateral bead narrow.</p> <p> <b>Elytra:</b> Subparallel, widest in the middle; humerus pronounced, rounded, humeral spot large; narrow median transverse band extending between 3 rd and 8 th stria, with strongly serrated edges, rounded and pointed towards suture; apical band narrow, reddish yellow, extending along the apical portion of stria; striations narrow, intervals wide, flat, glabrous.</p> <p> <b>Male Genitalia</b>: Median lobe slender compared to <i>P.devagiriensis</i> <b>sp. nov.</b>; highly arcuate, apex pointed.</p> <p> <b>Measurements</b>: <b>Holotype Male</b>, TLA= 16.16 mm; TLB= 15.84 mm; TW= 6.64 mm; PL = 3.28 mm; PW = 3.44 mm; EL = 9.52 mm.</p> <p> <b>Type Material</b>: 1 ex. Holotype, male, India: Kerala: Palakkad (10.806420°N, 76.690174°E), Hand Picking (wet paddy field), 26.XI.2017, coll. M. Divya, deposited at ZSIC.</p> <p>Paratype, male, India: Karnataka, 2013, coll. A. Anichtchenko.</p> <p> <b>Geographical distribution.</b> INDIA: Kerala: Palakkad; Karnataka</p> <p> <b>Collecting Circumstances</b>: Handpicked from a paddy field of Palakkad (India: Kerala), a region belonging to the Palakkad gap.</p> <p> <b>Etymology</b>: Named after ‘India’.</p> <p> <b>Remarks.</b> <i>Pheropsophus indicus</i> <b>sp. nov.</b> is similar to <i>P. occipitalis</i>, but differs in having broad ‘M’ shaped black spot on head, entirely black pronotum with straight apical and basal margins, broad elytra and narrow elytral median transverse band.</p>Published as part of <i>Venugopal, Akhil S. & Thomas, Sabu K., 2019, Bombardier beetles of the genus Pheropsophus Solier 1833 (Carabidae: Brachininae: Brachinini) from Indian subcontinent, pp. 65-89 in Zootaxa 4608 (1)</i> on page 86, DOI: 10.11646/zootaxa.4608.1.3, <a href="http://zenodo.org/record/3993611">http://zenodo.org/record/3993611</a&gt

    Pheropsophus devagiriensis Venugopal & Thomas 2019, sp. nov.

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    <i>Pheropsophus devagiriensis</i> sp. nov. <p>(Fig. 4 A, 5 A)</p> <p> <b>Specimens examined (n=6):</b> Holotype, labelled “ Male, India: Tamil Nadu: Courtallam (8.930855°N, 77.268843°E), Hand Picking, from under stones, 14.X.2015, coll. S.V. Akhil ”; Paratypes, 5 exs., India: Tamil Nadu: Courtallam (8.930855°N, 77.268843°E), 14.X.2015, coll. S.V. Akhil.</p> <p> <b>Description.</b> TLA: 20.0 mm; TW: 8.1 mm</p> <p> <b>Colour:</b> Head completely yellow without spots; clypeus (lateral edge brownish black) and labrum yellow with anterior brownish yellow border; fronto-clypeal suture light reddish brown; antennal segments 1–4 yellowish brown and 5–11 dark reddish brown; pronotum black with two large yellow spots on both sides of a narrow but prominent black median furrow, the two spots not reaching the lateral edge, lateral border being black; anterior and posterior margins of pronotum black; elytra with yellow patches including two small, yellow, rounded humeral spots, wide median transverse bands interrupted at suture and extreme apex; apical yellow band of elytra very narrow, just a small, fine yellow line; scutellum black; legs with coxa, trochanter, femur and tibia pale reddish yellow, tarsal end of tibia reddish brown, first tarsi with middle portion yellow and rest reddish brown, tarsi 2–5 reddish brown; claws dark brown; underside of head completely yellow; lateral side of the thorax with pale reddish yellow spot in the form of “T”; <i>metasternum</i> reddish yellow posteriorly and reddish brown anteriorly; <i>metepisternum</i> reddish yellow; rest of the ventral region brownish black.</p> <p> <b>Head:</b> <i>Eyes</i> prominent and protruding; <i>labrum</i> convex anteriorly; <i>vertex</i> with long supra orbital setae. Third antennal segment longer than segments 1 and 2 combined. <i>Mandibles</i> wide but short, protruding beyond the labrum; mandibular scrobe unisetose. <i>Palpi</i> pubescent with terminal segment dilated. <i>Submentum</i> setose with 4–5 long and 10–12 short setae. <i>Gular</i> sutures diverging.</p> <p> <b>Pronotum:</b> Narrowed posteriorly; sides rounded in the anterior half and parallel behind; beaded dark lateral margin; anterior and posterior margin straight; disc finely punctate but glabrous except for very few brown setae along lateral edges; anterior and posterior margins each with a fringe of short dense setae</p> <p> <b>Elytra:</b> convex on sides; with almost erased humerus; base narrower than apex, broadest just before apex. All nine striations (counting from the suture) well marked. Elytra very sparsely punctate with 1–3 setae on each intervals and a row of short yet sparse setae near apex.</p> <p> <b>Abdomen:</b> finely pubescent.</p> <p> <b>Male Genitalia</b>: Aedeagus with median lobe stout, low degree of curvature (only slightly curved); apex round- ed, blunt.</p> <p> <b>Measurements</b>: <b>Holotype Male</b>, TLA= 20 mm; TLB= 17.7 mm; TW= 8.1 mm; PL = 3.6 mm; PW = 3.7 mm; EL = 10.2 mm. <b>Paratype Female</b>, TLA= 21 mm; TLB = 16.8 mm; TW= 7.2 mm; PL = 3.6 mm; PW = 3.5 mm; EL = 9.6 mm</p> <p> <b>Type material</b>: Holotype male: India: Tamil Nadu: Courtallam (8.930855°N, 77.268843°E), 14.X.2015, handpicked from under stones, coll. S.V. Akhil, deposited at ZSIC. Paratypes: 1 male, 4 females, Tamil Nadu, Courtallam (8.930855°N, 77.268843°E), 14.X.2015, from under stones</p> <p> <b>Geographical distribution.</b> India: Tamil Nadu: Courtallam (Moist south Western Ghats eco-region)</p> <p> <b>Collecting circumstances</b>: All the six specimens were handpicked from under stones near to a stream.</p> <p> <b>Etymology</b>: This species is named after the host research institution.</p> <p> <b>Remarks.</b> <i>Pherosophus devagiriensis</i> <b>sp. nov.</b> is very similar to <i>P. hilaris</i> but differs from it by head entirely yellow, pronotum with bright yellow spot not reaching the lateral margin, lateral margin black, pronontal median furrow deep, disc glabrous and shiny, elytral humeral spot very small, elytral yellow apical band narrow.</p>Published as part of <i>Venugopal, Akhil S. & Thomas, Sabu K., 2019, Bombardier beetles of the genus Pheropsophus Solier 1833 (Carabidae: Brachininae: Brachinini) from Indian subcontinent, pp. 65-89 in Zootaxa 4608 (1)</i> on pages 83-86, DOI: 10.11646/zootaxa.4608.1.3, <a href="http://zenodo.org/record/3993611">http://zenodo.org/record/3993611</a&gt

    Drag and inertia coefficients for horizontally submerged rectangular cylinders in waves and currents

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    The results of an experimental investigation carried out to measure combined wave and current loads on horizontally submerged square and rectangular cylinders are reported in this paper. The wave and current induced forces on a section of the cylinders with breadth-depth (aspect) ratios equal to 1, 0.5, and 0.75 are measured in a wave tank. The maximum value of Keulegan-Carpenter (KC) number obtained in waves alone is about 5 and Reynolds (Re) number ranged from 6.3976103 to 1.186105. The drag (CD) and inertia (CM) coefficients for each cylinder are evaluated using measured sectional wave forces and particle kinematics calculated from linear wave theory. The values of CD and CM obtained for waves alone have already been reported (Venugopal, V., Varyani, K. S., and Barltrop, N. D. P. Wave force coefficients for horizontally submerged rectangular cylinders. Ocean Engineering, 2006, 33, 11-12, 1669-1704) and the coefficients derived in combined waves and currents are presented here. The results indicate that both drag and inertia coefficients are strongly affected by the presenceof the current and show different trends for different cylinders. The values of the vertical component inertia coefficients (CMY) in waves and currents are generally smaller than the inertia coefficients obtained in waves alone, irrespective of the current's magnitude and direction. The results also illustrate the effect of a cylinder's aspect ratio on force coefficients. This study will be useful in the design of offshore structures whose columns and caissons are rectangular sections

    Outcome of a repair-oriented strategy for the aortic valve in children

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    BACKGROUND: We sought to evaluate the mid-term results of a repair-oriented strategy of the aortic valve in children. METHODS: Between February 2007 and November 2011, we performed 39 aortic valve repairs in children. Median age and weight at surgery were 5.5 years (3 days-18 years) and 16.7 kg (2.7-83.5), respectively. A total of 11 (28%) patients had one or more prior surgical or interventional cardiologic procedures. Median intensive care unit and hospital stay were two (1-96) and five (3-96) days, respectively. Median and cumulative follow-up were 12.7 months (15 days-64 months) and 48.9 patient-years, respectively. RESULTS: There were 3 (7.7%) early deaths all in patients undergoing additional complex cardiac procedures. Two (5.1%) patients required early surgical revision. Twenty-six (66%) patients had isolated or mixed aortic stenosis. The median gradient reduced from 62.4 (range 16-144) to 17.6 mm Hg (range 0-51.8), postoperatively (P = .02). At last follow-up, the median gradient remained largely unchanged at 21.1 mm Hg (0-49; P = .02). Twenty-six (66%) patients had isolated or mixed aortic valve regurgitation (mild in 8 [20%], moderate in 15 [38%], and severe in 6 ([15%] patients). The degree of aortic regurgitation improved in all patients with moderate or severe aortic regurgitation (P = .04). At last follow-up, two patients had moderate aortic regurgitation. Kaplan Meier freedom from reintervention in the survivors was 95% at three years. CONCLUSIONS: A repair-oriented strategy for the aortic valve in children has satisfactory early and mid-term results and remains a promising management option in children with aortic valve disease

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia

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    Letter to the editorC N Hahn, P J Brautigan, C-E Chong, A Janssan, P Venugopal, Y Lee, A E Tims, M S Horwitz, M Klingler-Hoffmann, and H S Scot

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Supplementation of (Trigonella foenum-graecum L.) Fenugreek Leaves Stimulates the Insulin Action in Streptozotocin- Induced Diabetic Rats

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    Trigonella foenum-graecum (Fenugreek) leaves exhibit antidiabetic and antioxidant properties. The present study was designed to elucidate the insulin stimulatory effect on supplementation of fenugreek leaves in streptozotocin-induced diabetes in rats. Supplementation of fenugreek leaves mixed with diet at doses of 0.5g and 1.0g/kg of body weight twice daily to diabetic rats for a period of 45days resulted in change in bodyweight, increase in weight of pancreas, enhances the insulin levels and a significant decrease in fasting blood glucose levels. Histopathological observations showed marked changes of the pancreas in treatment with the fenugreek leaves improved the functional state of the pancreatic β-cells and partially retained the damage caused by streptozotocin to the pancreatic islets. These findings of our study clearly indicate the insulin stimulatory effect of fenugreek leaves. The effect observed with the fenugreek leaves was better than that of glibenclamide (600 µg/kg bodyweight). ----------------------------------------------------------------------------------1Reader, Department of Biochemistry, Sathyabama University Dental College and Hospital, Chennai, Tamil Nadu, India2Director of Research, Ex-Dean of Science, Department of Biochemistry and Biotechnology, Annamalai University, Chidambaram*Corresponding author, Email: [email protected], Ph: +91-44- 24503064, Mob: +91-9244488676Cite This Article As:Annida Balakrishnan and Venugopal. P. Menon. 2010. Supplementation of (Trigonella foenum-graecum L.) Fenugreek Leaves Stimulates the Insulin Action in Streptozotocin- Induced Diabetic Rats. J. Ecobiotechnol. 2(3): 26-32
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