305,143 research outputs found
PIPERITENONE OSSIDO E FARMACI ANTIMICOTICI: INTERAZIONI E LORO IMPIEGO NELLA FARMACO RESISTENZA
No full textModificazioni morfologico strutturali e funzioni indotte da agenti antimicrobici in ceppi farmacoresistenti di Candida albicans.
No full textCandida albicans è un fungo che può esistere sia come
colonizzatore innocuo, ovvero commensale del tratto
gastrointestinale e genitale dell’uomo, sia come patogeno
opportunista quando l’ospite presenta una compromissione
del sistema immunitario. C. albicans può causare
l’invasione di tessuti ed organi dando luogo talvolta
ad infezioni intrattabili. L’aumento della sua presenza
nella popolazione e nel numero delle infezioni documentate
è dovuto all’uso sempre più indiscriminato di terapie
immunosoppressive ed antibiotiche ad ampio spettro.
Questo microrganismo esiste in tre forme cellulari fenotipicamente
distinte: lievito o blastospora, pseudoifa ed
ifa. La morfogenesi rappresenta un focus di ricerca in C.
albicans dal momento che la virulenza è associata con la
capacità di passare dallo stadio di lievito a quello ifale: le
cellule che non formano prontamente ife spesso hanno
virulenza ridotta [1].
Lo studio dei fattori di virulenza di C. albicans tiene
necessariamente conto dello stato immune dell’ospite:
quando lo stato immune non è compromesso la forma
virulenta non causa infezioni. Per tale motivo le infezioni
fungine opportunistiche rappresentano una importante
causa di morbidità e mortalità nei pazienti immunocompromess
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
Osteoarthritis of the foot: A review of the current state of knowledge
No full textFoot osteoarthritis (OA) is a very common disease that mainly affects older people deeply influencing their quality of life. The joint most frequently involved in the articular degenerative process is the first metatarsophalangeal joint. Its severe impairment may lead to a specific clinical pattern known as hallux rigidus that often requires surgical treatment. Currently conventional radiograms of feet associated with an accurate clinical examination should be performed in order to diagnose foot OA. However, new imaging modalities as ultrasonography and magnetic resonance imaging are emerging as valuable tools to assess foot OA. Therapeutic options for foot OA consist of conservative strategies, including life-style modification and pharmacological treatment, options that are usually adopted in early-stage disease and in invasive surgical procedures reserved to late-stage conditions. At the present time there is a lack of evidence in international literature specifically dealing with foot OA, so further investigation on this topic is required to clarify its pathogenesis, the diagnostic pathway and the best clinical management
Giocattoli pericolosi: un’indagine conoscitiva tra gli insegnanti della scuola materna nella provincia di Salerno
No full textRELAZIONI INTERNAZIONAL
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
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