258 research outputs found
T(Rho) and magnetization transfer and INvErsion recovery (TRAMINER)-prepared imaging: a novel contrast-enhanced flow-independent dark-blood technique for the evaluation of myocardial late gadolinium enhancement in patients with myocardial infarction
No full textPurpose: To evaluate a new dark-blood late gadolinium enhancement (LGE) technique called “T(Rho) And Magnetization transfer and INvErsion Recovery” (TRAMINER) for the ability to detect myocardial LGE versus standard “bright-blood” inversion recovery (SIR) imaging. Materials and Methods: This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant prospective study included 40 patients (62 ± 14 years [mean ± standard deviation (SD)], 29 males) with suspected myocardial infarction (MI) referred for the assessment of myocardial viability. The patients underwent a 1.5T cardiac magnetic resonance imaging (MRI) including postcontrast SIR and TRAMINER acquisitions. Normalized images were evaluated by two readers. Subjective (3-point Likert scale) and objective image qualities were compared using Mann–Whitney U-test and paired t-test, respectively. Interobserver agreement, LGE detection rate, and level of certainty were compared using Cohen's kappa, Wilcoxon-test, and Mann–Whitney U-test, respectively. Results are reported as mean ± SD or mean [95% confidence interval]. Results: Overall, image quality was rated similar between TRAMINER and SIR; however, TRAMINER performed better on a visual assessment of the ability to differentiate LGE from blood (Likert scale: 3.0 [3.0–3.0] vs. 2.0 [1.7–2.2], P < 0.0001). TRAMINER provided significantly higher signal intensity range (69.8 ± 10.2 vs. 9.6 ± 7.6, P < 0.0001) and a 4-fold higher signal intensity ratio (4.2 ± 1.9 vs. 1.1 ± 0.1, P < 0.0001) between LGE and blood signals. TRAMINER detected more patients (19/40 vs. 17/40) and segments (91/649 vs. 79/649) with LGE with higher level of certainty (2.9 [2.8–3.0] vs. 2.7 [2.5–2.8], P = 0.0185). Interobserver agreement was good to excellent for LGE detection. Conclusion: TRAMINER provides better contrast between LGE and blood and consequently may have increased ability to discriminate thin subendocardial and papillary muscle enhancement from the blood signal, which can have an indistinct appearance using SIR. Level of Evidence: 2. J. MAGN. RESON. IMAGING 2017;45:1429–1437
Novel sites of CCK2R expression: Characterisation and functional significance of gastrin receptor expression in gastrointestinal myofibroblasts and human melanoma cancer cells
No full textNesting Well-Defined Pt Nanoparticles within a Hierarchically Porous Polymer as a Heterogeneous Suzuki–Miyaura Catalyst
No full textA hierarchically porous polymer (HPP) consisting of micropores (similar to 1 nm) within a 3D continuous mesoporous wall (similar to 15 nm) was used to support well-defined Pt nanoparticles (2 nm in diameter) as a heterogeneous catalyst for the Suzuki-Miyaura cross-coupling reaction in the liquid phase. The ligand-capped nanoparticles were loaded into the polymer and treated with plasma to expose the active surface. The dual porosity was essential: the block polymer-templated mesopores provided the reactants facile access to the nanoparticle center, which was firmly immobilized by the microporous surface. Compared to inorganic mesoporous silica supports, which are intrinsically susceptible to basic hydrolysis, the Pt-HPP featured higher activity for all halide leaving groups, even in green solvents, as well as excellent recyclability. Only 5% decrease in activity was observed after 10 cycles. Pt-HPP was one of the most active heterogeneous catalysts for aryl chloride substrates compared to literature Pt or Pd examples.
Intra-individual comparison of epicardial adipose tissue characteristics on coronary CT angiography between photon-counting detector and energy-integrating detector CT systems
No full textPurpose: To explore the potential differences in epicardial adipose tissue (EAT) volume and attenuation measurements between photon-counting detector (PCD) and energy-integrating detector (EID)-CT systems. Methods: Fifty patients (mean age 69 +/- 8 years, 41 male [82 %]) were prospectively enrolled for a research coronary CT angiography (CCTA) on a PCD-CT within 30 days after clinical EID-based CCTA. EID-CT acquisitions were reconstructed using a Bv40 kernel at 0.6 mm slice thickness. The PCD-CT acquisition was reconstructed at a down-sampled resolution (0.6 mm, Bv40; [PCD-DS]) and at ultra-high resolutions (PCD-UHR) with a 0.2 mm slice thickness and Bv40, Bv48, and Bv64 kernels. EAT segmentation was performed semi-automatically at about 1 cm intervals and interpolated to cover the whole epicardium within a threshold of -190 to -30 HU. A subgroup analysis was performed based on quartile groups created from EID-CT data and PCD-UHRBv48 data. Differences were measured using repeated-measures ANOVA and the Friedman test. Correlations were tested using Pearson's and Spearman's rho, and agreement using Bland-Altman plots. Results: EAT volumes significantly differed between some reconstructions (e.g. EID-CT: 138 ml [IQR 100, 188]; PCD-DS: 147 ml [110, 206]; P<0.001). Overall, correlations between PCD-UHR and EID-CT EAT volumes were excellent, e.g. PCD-UHRBv48: r: 0.976 (95 % CI: 0.958, 0.987); P<0.001; with good agreement (mean bias: -9.5 ml; limits of agreement [LoA]: -40.6, 21.6). On the other hand, correlations regarding EAT attenuation was moderate, e.g. PCD-UHRBV48: r: 0.655 (95 % CI: 0.461, 0.790); P<0.001; mean bias: 6.5 HU; LoA: -2.0, 15.0. Conclusion: EAT attenuation and volume measurements demonstrated different absolute values between PCD-UHR, PCD-DS as well as EID-CT reconstructions, but showed similar tendencies on an intra-individual level. New protocols and threshold ranges need to be developed to allow comparison between PCD-CT and EID-CT data
Revaluating regional influences of ICT factors in Hungary
No full textAt the beginning of the 21st century ICT factors got growing importance in shaping regional differences in Hungary. Determining differences of ICT competitiveness became needful in analysing regional inequalities recently, however, according to some opinions there are ICT-like factors on the scene for longer time. Depending on theories and interpretations these factors are treated mainly as new although sometimes as traditional ones. In accordance with the generally accepted approaches ICT factors began to demonstrate their effects in the last decades. Other (wider) approaches on the contrary state that the most characteristic elements of ICT presented themselves earlier in determining regional differences that have been supplemented only with features of modern communication infrastructure. The paper focuses on measuring the spatial differentiating influence of ICT factors within Hungary. By the means of regression models it is presented what explanatory force can be connected to ICT factors in determining the level of regional competitiveness and development. In connection with the results the rank of regions could be revaluated in the socio-economic competition of the new century.
Calvin United Church of Christ Confirmation Class, 1920
No full textA photograph of the 1920 confirmation class of Calvin United Church of Christ with Reverend Louis Bogar.<jtf £?/#^0Z
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Bottom Row L-R - B. Remias, 3. Orosz, S. Kerekes, H. Juhaaz, H« Olah, T. Pozsgay,
E. Lacza, Rev. L. Bogar, E. Lehoczky, M. Arvay, I. ?eto, E. Varro, J# Kupecz
2 nd. Row L-R - E. Komaromy, J. Barta, M. Lipot, I. Erdelyi, Lc Sipos, J.Jakcsy,
R. Vargo, I. Szabo, EI Szabo, E# Krozer, E. Arvay, E. Ando," S. Kardos,
R. Boszpoly, 3rd Row L-R - J. Szekerea, J. Mihalko, S. Fodor, J. Papp, A. Boktor,
Wm. Csontos, J. Takacs, 3. Kostyo, 3. Szilagyi, B. Mesteller, 3. Kertesz,
4th Rwo L-R - P. Gulyas, 3. Virag, A. Rasy, J. Akos, 3. Bemeter, J. Papp, F0 Nagy,
J. Materni, J. Toth. 5th Row L-R - A. Papp, P. Varga, 3. Virag,"""""""""
J. Mihalko, John Remia
Adversarial stylometry in the wild : transferable lexical substitution attacks on author profiling
No full textAbstract: Written language contains stylistic cues that can be exploited to automatically infer a variety of potentially sensitive author information. Adversarial stylometry intends to attack such models by rewriting an author's text. Our research proposes several components to facilitate deployment of these adversarial attacks in the wild, where neither data nor target models are accessible. We introduce a transformerbased extension of a lexical replacement attack, and show it achieves high transferability when trained on a weakly labeled corpus-decreasing target model performance below chance. While not completely inconspicuous, our more successful attacks also prove notably less detectable by humans. Our framework therefore provides a promising direction for future privacy-preserving adversarial attacks
Evaluation of convective parameters derived from pressure level and native ERA5 data and different resolution WRF climate simulations over Central Europe
No full textThe mean climatological distribution of convective environmental parameters from the ERA5 reanalysis and WRF regional climate simulations is evaluated using radiosonde observations. The investigation area covers parts of Central and Eastern Europe. Severe weather proxies are calculated from daily 1200 UTC sounding measurements and collocated ERA5 and WRF pseudo-profiles in the 1985-2010 period. The pressure level and the native ERA5 reanalysis, and two WRF runs with grid spacings of 50 and 10 km are verified. ERA5 represents convective parameters remarkably well with correlation coefficients higher than 0.9 for multiple variables and mean errors close to zero for precipitable water and mid-tropospheric lapse rate. Monthly mean mixed-layer CAPE biases are reduced in the full hybrid-sigma ERA5 dataset by 20-30 J/kg compared to its pressure level version. The WRF model can reproduce the annual cycle of thunderstorm predictors but with considerably lower correlations and higher errors than ERA5. Surface elevation differences between the stations and the corresponding grid points in the 50-km WRF run lead to biases and false error compensations in the convective indices. The 10-km grid spacing is sufficient to avoid such discrepancies. The evaluation of convection-related parameters contributes to a better understanding of regional climate model behavior. For example, a strong suppression of convective activity might explain precipitation underestimation in summer. A decreasing correlation of WRF-derived wind shear away from the western domain boundaries indicates a deterioration of the large-scale circulation as the constraining effect of the driving reanalysis weakens
Funzioni e oggetti della catalogazione per autore e titolo. Un contributo alla teoria della catalogazione
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