1,354,100 research outputs found
Role of genetic polymorphisms of the dopaminergic system in Parkinson's disease patients with impulse control disorders
No full textAlzheimer`s Disease Neuroimaging Initiative. ApoE ε4 allele relateted alterations in hippocampal connectivity in early Alzheimer's disease support memory performance
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Patterns of cortical thickness associated with impulse control disorders in Parkinson's disease
Get PDFCognitive profiling of Parkinson disease patients with mild cognitive impairment and dementia
Get PDFVariations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A new interpretative paradigm for conformational protein diseases.
No full textConformational Protein Diseases (CPDs) comprise over forty clinically and pathologically diverse disorders in
which specific altered proteins accumulate in cells or tissues of the body. The most studied are Alzheimer's disease, Parkinson's
disease, Huntington's disease, amyotrophic lateral sclerosis, prion diseases, inclusion body myopathy, and the systemic
amyloidoses. They are characterised by three dimensional conformational alterations, which are often rich in -
structure. Proteins in this non-native conformation are highly stable, resistant to degradation, and have an enhanced tendency
to aggregate with like protein molecules. The misfolded proteins can impart their anomalous properties to soluble,
monomeric proteins with the same amino acid sequence by a process that has been likened to seeded crystallization. However,
these potentially pathogenic proteins also have important physiological actions, which have not completely characterized.
This opens up the question of what process transforms physiological actions into pathological actions and most intriguing,
is why potentially dangerous proteins have been maintained during evolution and are present from yeasts to humans.
In the present paper, we introduce the concept of mis-exaptation and of mis-tinkering since they may help in clarifying
some of the double edged sword aspects of these proteins. Against this background an original interpretative paradigm
for CPDs will be given in the frame of the previously proposed Red Queen Theory of Aging
Role of genetic polymorphisms of the dopaminergic system in Parkinson's disease patients with impulse control disorders
No full textDispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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