115 research outputs found
The administration of PD-1 and PD-L1 inhibitors in pediatric hematology: a literature review
No full textThe discovery of immune checkpoints (IC) has become a landmark event in immuno-oncolog y, improving the understanding of the mechanisms of tumor cells evading immune sur veillance. Based on this, a group of drugs such as immune checkpoint inhibitors (ICIs) were developed, the ef fect of which is due to the rupture of the immunological synapse and recognition by tumor T cells. Currently, ICIs are successfully used in the treatment of a number of malignant neoplasms, improving the indicators of diseasefree and overall sur vival. However, determining the role of these drugs in the treatment of children with tumors of the blood system is the subject of active research. This article presents a review of the literature on topical aspects of the administration of PD-1 and PD-L1 inhibitors in pediatric hematolog y. Their mechanisms of action, ef fectiveness and potential complications of therapy are presented
Research of the Power Plant Operational Modes
No full textIn this article the algorithm of the power plant operational modes research is offered. According to this algorithm the program for the modes analysis and connection power transformers choice is developed. The program can be used as educational means for studying of the power plant electric part, at the same time basic data are provided. Also the program can be used for the analysis of the working power plants modes. Checks of the entered data completeness and a choice correctness of the operational modes are provided in the program; in all cases of a deviation from the correct decisions to the user the relevant information is given
A META-ANALYSIS OF THE PUBLIC-PRIVATE PARTNERSHIP LITERATURE REVIEWS: EXPLORING THE IDENTITY OF THE FIELD
No full textThe growing literature in PPP has made the field multi-disciplinary, over-differentiated, and unconsolidated. Taking a meta-analysis lens, this study investigates an unexplored identity of the field. It consolidates 61 review articles in PPP, analyses them across numerous review categories, and provides implications and suggestions for future studies. The review categories include the purpose of study, methods used, dataset details, journal and author details, primary disciplinary focus, awareness of previous review studies, and evolution of the PPP review literature. The findings reveal that the literature progressed through four evolution phases: from initiation, formation, growth, to expansion. Future review works should involve more empirical studies and examine the practical relevance of the PPP research. Promising areas are PPP governance, complexity, post-transfer phases, sustainability-related issues, and real estate development through PPP. The PPP researchers in construction engineering and management, property management, public management, and transportation will benefit from understanding the field’s identity, how it is currently being formed, promising areas, and where the literature is evolving
Early warning systems for financial crises in the conditions of modern Russian economy: specificity and application. Master thesis
No full textThe compiled database covers 60 years of recent financial history of 47 economies and is first to include the 2018 crisis in Turkey and the 2020 sovereign debt crisis in Argentina. It covers such variables as debt/gdp levels for different sectors of the economy (state, households, nonfinancial and financial sector), credit/gdp gap, residential property price statistics,
The paper is focused on early warning indicators of financial crises applicable to Russia. Using the stepwise regression approach the author identifies early warning indicators for banking and currency crises in advanced and emerging market economies. The proposed prediction model for banking crisis in Russia and emerging market economies includes credit gap and real residential property price index growth. The author explores the possibility of inclusion of residential property price index into the informational base for the countercyclical capital buffer estimation by the Bank of Russia. An analysis of currency crises indicates that private debt-to-service ratio contains useful information for prediction of currency crisis in Russia and emerging market economies.
Compiled data is based on statistics published by Bank for International Settlements, Institute for International Finance and Joint External Debt Hub
L-asparaginase: New about Well-Known Drug
No full textThe history of asparaginase clinical use is inextricably linked to the improvement of treatment programs for acute lymphoblastic leukaemia (ALL). Asparaginase, obtained from E. coli, has become the crucial part in the protocols for the treatment of ALL in children and adults since the 1960s-1970s due to its antitumor effect on lymphoid leukemia cells. Despite the evolution of therapeutic approaches in ALL management, changes in used chemotherapeutic agents, their administration regimens and doses, the asparaginase remains one of the leading therapeutic agents in ALL patients. With time ideas about the asparaginase mechanisms have expanded, new data have been accumulated on adverse effects (allergic reactions, thrombotic complications, pancreatitis, hepatic dysfunction, etc.). The asparaginase obtained from Erwinia chrysanthemi and PEGylated forms of the drug were used to reduce the frequency of any of such adverse effects. This literature review provides current concepts on the mechanism of L-asparaginase dosage forms action, describes side effects associated with the use of this medication. We also present our own clinical case of L-asparaginase (obtained from Erwinia chrysanthemi) administration in ALL patient with allergic reaction to PEG-L-asparaginase
Developing Learning Trajectory For Enhancing Students’ Relational Thinking
No full textAlgebra is part of Mathematics learning in Indonesian curriculum. It takes one half of the teaching hours in senior high school, and one third in junior high school. However, the learning trajectory of Algebra needs to be improved because teachers teach computational thinking by applying paper-and-pencil strategy combining with the concepts-operations-example-drilling approach. Mathematics textbooks do not give enough guidance for teachers to conduct good activities in the classroom to promote algebraic thinking especially in the primary schools.
To reach Indonesian Mathematics teaching goals, teachers should develop learning trajectories based on pedagogical and theoretical backgrounds. Teachers need to have knowledge of student’s developmental progressions and understanding of mathematics concepts and students’ thinking. Research shows that teachers’ knowledge of student’s mathematical development is related to their students’ achievement. In fostering a greater emphasis on algebraic thinking, teachers and textbooks need to work more closely together to develop a clearer learning trajectory. Having this algebraic thinking, students developed not only their own character of learning and thinking but also their attitude, attention and discipline.
Key Words: Learning Trajectory, Relational Thinkin
Integrating technical performances within design exploration: The case of an innovative Trombe wall
No full textThe Double Face 2.0 research project aims at developing a novel type of an adaptive translucent Trombe wall. The novelty of the proposed system is based on the integration of new lightweight and translucent materials, used both forlatent heat storage and insulation, advanced computational design processes, used to identify the relationship between variations in geometry and their effect in terms of overall performance, as well as proposed fabrication methods basedon Fused Deposition Modelling. Various concepts and geometric configurations are explored and improved via a computational design workflow. The exploration is deeply rooted in performance simulations manufacturing constraints and measurements of prototypes. The paper presents the workflow of the overall on-going research project, with specific emphasis on the incorporation of a omputational assessment and optimization process. Moreover, it presents the preliminary set of measurements and simulations for thermal performances, their results and related conclusions.Design InformaticsBuilding Physic
PENGARUH PERILAKU MASYARAKAT TERHADAP PENGELOLAAN SAMPAH DI DESA KEBUNDADAP TIMUR KECAMATAN SARONGGI KABUPATEN SUMENEP
No full textCritical population expansion and changes in individual utilization design indirectly increase the volume, type, and characteristics of waste, much more differently. Home life also generates waste. Information from the BPS in 2022, the population in the village of Kebundadap Timur is 3060 people. Many people there are still not ready to manage their waste properly. Residents like to throw their garbage into the river or by burning it around the house. Thus, the problem of family waste is also experienced by the people of East Kebundadap village. The purpose of this study was to determine the effect of community behavior on waste management in East Kebundadap village. This study uses a quantitative approach with associative research methods. The population in this study was the people of Kebundadap Timur Village, amounting to 3060 people with a sampling technique using purposive sampling with an error rate of 10% which resulted in 97 members as respondents in this study. The instrument used by distributing questionnaires to respondents. Analysis of the data used is simple linear regression analysis. Based on the results of the research and discussion that has been described by the author about the influence of community behavior on waste management in the village of Kebundadap Timur, it can be said that the influence of community behavior on waste management in the Village of Kebundadap Timur is a positive influence and means that community behavior is able to improve management This is evidenced by the results of analysis using multiple linear regression, namely the regression equation of Y = 8.084 + 0.756X, based on the R value of 0.663 which means it has a strong relationship between variables and variables, based on the results of the F test and T test which also concludes that community behavior variables have a significant effect on waste management in East Kebundadap Village.Ekspansi populasi yang kritis dan perubahan desain pemanfaatan individu secara tidak langsung meningkatkan volume, jenis, dan karakteristik sampah, jauh lebih berbeda. Kehidupan rumahan juga menghasilkan sampah. Informasi dari BPS tahun 2022, jumlah penduduk di desa Kebundadap Timur sebanyak 3060 orang. Banyak orang disana masih belum siap untuk mengelola sampah dengan benar. Penduduk suka membuang sampah mereka ke sungai atau dengan membakarnya di sekitar rumah. Dengan demikian, persoalan tentang sampah keluarga juga dialami masyarakat desa Kebundadap Timur. Tujuan Penelitian ini adalah mengetahui pengaruh perilaku masyarakat terhadap pengelolaan sampah di desa Kebundadap Timur. Penelitian ini menggunakan pendekatan kuantitatif dengan metode penelitian asosiatif. Populasi pada penelitian ini adalah masyarakat Desa Kebundadap Timur yang berjumlah 3060 orang dengan teknik pengambilan sampel menggunakan purposive sampling dengan tingkat eror 10% yang menghasilkan 97 anggota sebagai responden dalam penelitian ini. Instrumen yang digunakan dengan penyebaran kuesioner kepada responden. Analisis data yang digunakan adalah analisis regresi linear sederhana. Berdasarkan dari hasil penelitian dan pembahasan yang telah diuraikan oleh penulis tentang pengaruh perilaku masyarakat terhadap pengelolaan sampah di desa kebundadap timur, maka dapat disimpulkan bahwa pengaruh perilaku masyarakat terhadap pengelolaan sampah yang ada di Desa Kebundadap Timur yaitu berpengaruh positif dan signifikan artinya bahwa perilaku masyarakat mampu meningkatkan pengelolaan sampah hal ini dibuktikan melalui hasil analisis menggunakan regresi linier berganda yaitu menghasilkan persamaan regresi sebesar Y = 8.084 + 0.756X, berdasarkan nilai R sebesar 0.663 yang artinya memiliki tingkat hubungan kuat antar variabel bebas dan variabel terikat, berdasarkan hasil uji F dan ujia T yang juga memberikan kesimpulan bahwa variabel perilaku masyarakat berpengaruh signifikan terhadap pengelolaan sampah di Desa Kebundadap Timur
Clinical and Immunomorphological Characteristics of Lymphomatoid Papulosis Type E (Literature Review and Case Report)
No full textLymphomatoid papulosis (LP) is a rare variant of benign lymphoproliferative disease with skin involvement. Based on clinical, morphological, and immunobiological characteristics, WHO hematopoietic and lymphoid tissue tumor classification (2016) differentiates between several LP types: А, В, С, D, Е, and with 6p25.3 rearrangement. The present article reviews the literature on clinical course, pathomorphological, immunological, and biomolecular characteristics of LP in adults and children. For the first time in the domestic literature, it provides a case report of LP, type E, in a 2-year-old child. Differential diagnosis and optimal disease management of LP are also described in detail
Research Productivity in Emerging Economies: Empirical Evidence from Kazakhstan
No full textThe growth of the Higher Education and Science (HES) sector is positively associated with its research productivity and has a high potential in emerging countries. To explore such research productivity, this study offers a comprehensive analysis of the scientific literature from Kazakhstan. Our methods included descriptive analysis, network analysis, and author-based productivity analysis (by Lotka’s law) of 23,371 articles from Scopus, published during 1991–2020, and across 25 subject areas. The results of the descriptive analysis showed a substantial increase in the number of and citations to the literature since 2011 in almost all subject areas. However, the network analysis found that research in natural sciences was more developed in topical relationships and international collaborations than research in arts and humanities, social, and medical sciences. The Lotka’s law application revealed that the overall scientific literature in Kazakhstan did not reach its necessary stage of maturity. Additionally, some subject areas demonstrated greater contribution to the overall knowledge base, while others were less productive or lagging in their development. Our findings, useful for researchers and policymakers in emerging countries, can be exemplary in understanding the results of policy reforms aimed to improve the HES sector in emerging countries
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