1,806 research outputs found
Tree rings stable C isotopes as indicators of climatic change in the Mediterranean basin.
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RIC-HSCT for MF/SS
Get PDFAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Increased expression of CD40 ligand in activated CD4+ lymphocytes of systemic sclerosis patients
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Electrical properties of gold-polymer composite films
No full textElectrical conductivity measurements in the range 50-300 K have been carried out on gold-fluorocarbon-polymer composite films. Such measurements have been performed on samples with different percentages in volume of gold, before and after thermal annealing up to 450 K. The experimental temperature dependence of conductivity, in the range 50-300 K, follows the exponential law sigma=sigma (0) exp[-(T-0/T)(gamma)], where T-0 and gamma are constants. Best fit analyses carried out on experimental conductivity data, before and after thermal annealing, give values of gamma that can be related to the gold content of the film and to the size of grains embedded in the polymeric matrix. Such results suggest that grain redistribution can take place after thermal annealing and that the grains tend to coalesce. Dependence of conductivity on temperature during heating and cooling processes is also discussed. (C) 2001 American Institute of Physics
Imaging of carotid plaque angiogenesis
No full textDisplay Settings:AbstractFormat SummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListApplySend to:Choose DestinationFileClipboardCollectionsE-mailOrderMy Bibliography Format Summary (text)Abstract (text)MEDLINEXMLPMID ListCSV Create File 1 selected item: 19372660 Format SummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other Data E-mail Additional text E-mail "SPAM" filtering software notice Add to Clipboard Add to Collections Order articles Add to My Bibliography Cerebrovasc Dis. 2009;27 Suppl 2:48-54. Epub 2009 Apr 16. Imaging of carotid plaque angiogenesis. Vicenzini E, Giannoni MF, Benedetti-Valentini F, Lenzi GL. SourceDepartment of Neurological Sciences, Sapienza University of Rome, Rome, Italy. [email protected] Abstract Currently, characterization of the vulnerable plaque is a hot research topic as a more adequate strategy for preventing cerebrovascular events is being sought. Histological studies have recognized that plaque inflammation and the presence of adventitial vasa vasorum, intimal angiogenesis and plaque neovascularization are strong predictors of instability in atheromatous lesions of cerebrovascular and cardiovascular patients. The in vivo study of these features has been the focus of development of several new radiological imaging methods. Carotid ultrasound, with ultrasound contrast agents, is not only able to provide an enhanced assessment of the arterial lumen and plaque morphology with an improved resolution of the carotid intima-media thickness, but also to directly visualize adventitial vasa vasorum and plaque neovascularization. This technique and its future clinical implications are discussed in the present review. Copyright 2009 S. Karger AG, Basel. PMID: 19372660 [PubMed - indexed for MEDLINE
Preparation of mono-sized epoxy/MF microcapsulesin the appearance of polyvinyl alcohol as co-emulsifier
No full textFor epoxy microcapsules embedded in concrete as mechanic-triggered self-healing adhesive, globular shape with uniform size is the basic requirement to ensure the solid shell broken and the liquid core released at a designed stress. In this paper, monodispersed melamine\u96formaldehyde (MF) resin-walled epoxy E-51 microcapsules were successfully fabricated in an in situ polycondensation process, in which a certain amount of polyvinyl alcohol (PVA) solution was added as coemulsifier to control the microcapsules\u92 shape and size. Detail investigation shows, with the cooperation of PVA, the microcapsule morphologies and size distribution were ease to be adjusted by the parameters such as emulsifying agents, agitation rate, pH value and acidification time
Male infertility and copy number variants (CNVs) in the dog: a two-pronged approach using Computer Assisted Sperm Analysis (CASA) and Fluorescent In Situ Hybridization (FISH).
No full textBACKGROUND:
Infertility affects ~10-15% of couples trying to have children, in which the rate of male fertility problems is approximately at 30-50%. Copy number variations (CNVs) are DNA sequences greater than or equal to 1 kb in length sharing a high level of similarity, and present at a variable number of copies in the genome; in our study, we used the canine species as an animal model to detect CNVs responsible for male infertility. We aim to identify CNVs associated with male infertility in the dog genome with a two-pronged approach: we performed a sperm analysis using the CASA system and a cytogenetic-targeted analysis on genes involved in male gonad development and spermatogenesis with fluorescence in situ hybridization (FISH), using dog-specific clones. This analysis was carried out to evaluate possible correlations between CNVs on targeted genes and spermatogenesis impairments or infertility factors.
RESULTS:
We identified two genomic regions hybridized by BACs CH82-321J09 and CH82-509B23 showing duplication patterns in all samples except for an azoospermic dog. These two regions harbor two important genes for spermatogenesis: DNM2 and TEKT1. The genomic region encompassed by the BAC clone CH82-324I01 showed a single-copy pattern in all samples except for one dog, assessed with low-quality sperm, displaying a marked duplication pattern. This genomic region harbors SOX8, a key gene for testis development.
CONCLUSION:
We present the first study involving functional and genetic analyses in male infertility. We set up an extremely reliable analysis on dog sperm cells with a highly consistent statistical significance, and we succeeded in conducting FISH experiments on sperm cells using BAC clones as probes. We found copy number differences in infertile compared with fertile dogs for genomic regions encompassing TEKT1, DNM2, and SOX8, suggesting those genes could have a role if deleted or duplicated with respect to the reference copy number in fertility biology. This method is of particular interest in the dog due to the recognized role of this species as an animal model for the study of human genetic diseases and could be useful for other species of economic interest and for endangered animal species
Safe use of Grafts from HBcAb Positive Donors in Liver Transplantation -Analysis of Matching and Outcome
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