1,720,969 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Subcutaneous abscess as a side-effect of cetuximab therapy
No full textCetuximab, a chimeric monoclonal antibody against epidermal growth factor receptor (EGFR), is used to treat colorectal cancer and head and neck squamous-cell carcinoma (SCC) [2]. Common adverse events associated with cetuximab treatment are paronychia, diarrhea, and nausea, but most frequently acneiform eruption (>90%, with 20% grade 3/4 severity) [1].
A 68-year-old man with tonsil SCC (cT4aN1Mo according to the TNM classification) underwent radio-chemotherapy with cetuximab and hyperfractionated radiotherapy. Cetuximab was infused intravenously according to the traditional protocol, which consists of a loading dose of 400/m2 (total dose 780 mg) over 2 h, followed by 250/m2 (total dose 485-585 mg) weekly for 7 weeks.
Dermatological examination showed grade 3 skin and mucous membrane toxicities (according to the National Cancer Institute–CTCAE criteria) [2] with confluent oral pseudomembranous ulcers, widespread folliculitis with erythema on the face and upper trunk, and bleeding induced by minor trauma.
At the end of the 7th cycle, a tight, erythematous, painful abscess, 9-10 cm in diameter, arose on the patient's right buttock (figure 1). There was no fever, the patient was not diabetic nor immunocompromised, and all laboratory parameters were within normal ranges. Oral clarithromycin 1 g daily and chlorphenamine maleate 8 mg daily for 5 days did not result in significant improvement. Surgical drainage of the abscess on the 6th day yielded a culture positive for Staphylococcus aureus.
The response to cetuximab treatment was initially good, with a marked reduction of the primary tumor and involved lymph nodes on the imaging studies. However, a year after chemotherapy, the patient required further surgery due to tumor spread to other lymph nodes and the sphenoid sinus.
The EGFR family of receptor tyrosine kinases is at the beginning of a complex signal cascade that modulates cell proliferation, differentiation, migration and survival. It is overexpressed in several epithelial neoplasms, including head and neck SCC, non-small-cell lung, colon, prostate, ovarian and kidney cancers. EGFR blockade by target monoclonal antibodies (such as cetuximab) represents a novel strategy for cancer treatment.
Skin reactions associated with cetuximab are acne-like rash, cutaneous xerosis, paronychia, telangiectasia, itch, xerophthalmia, eyelash trichomegaly and residual hyperpigmentation. Acneiform rash is the commonest adverse event, with a characteristic distribution in seborrheic areas (face, V-shaped neckline, upper trunk). The skin lesions sometimes consist of erythematous follicular papules that may evolve into pustules. The pathogenesis of acneiform rash is unclear. EGF family receptors play important roles in protecting the hair follicle from immunomediated damage and in permitting the transition of hair and vellus hairs from the growth (anagen) to the involution phase (catagen). Consequently, EGFR inhibition keeps vellus hairs in the catagen phase for a long time, resulting in follicle damage. Abscess formation in our patient was probably due to a combination of cetuximab-induced folliculitis and S. aureus superinfection.
There is no standard treatment for the rash induced by EGFR-inhibitors, and there are different views on antibiotic prophylaxis in patients receiving cetuximab [1]. Its effectiveness has not been proven because the cause of the acneiform eruption is initially inflammatory, but is then frequently followed by superinfection. Moreover, the contradictory results of the few relevant trials [3, 4] do not warrant routine use of this approach. A recent uncontrolled open label follow-up study [5] reported a significant improvement of cetuximab-induced acneiform eruptions by topical therapy with nadifloxacin cream and prednicarbate cream. In another study [6], grades equal to or higher than the second were successfully treated with oral tetracyclines. However, no controlled studies on the interference between systemic therapy and tumor response to EGFR inhibitors are currently under way.
In our patient antibiotic prophylaxis would probably have prevented abscess formation, improving his condition and enabling a better management
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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