2,344 research outputs found
Letter from Geraldine Ferraro to Italian Author, Alfredo Ferraro
No full textLetter from Geraldine Ferraro to Italian author, Alfredo Ferraro. Geraldine Ferraro thanks him for sending a copy of his book.https://ir.lawnet.fordham.edu/vice_presidential_campaign_correspondence_1984_international/1166/thumbnail.jp
An interview with Alfredo Falcone and Lisa Salvatore: RECOURSE and trifluridine/tipiracil in metastatic colorectal cancer
No full textProfessor Alfredo Falcone and Dr Lisa Salvatore speak to Roshaine Gunawardana, Managing Commissioning Editor: Professor Alfredo Falcone is the Director of the Department of Oncology and the Specialization School at the University Hospital of Pisa, Italy. He trained in Pisa and Genoa, Italy, and has held major positions in Italian oncology since 2000. He currently has more than 300 publications, including papers in peer-reviewed international and national journals, book chapters, and more than 600 abstracts of presentations to international and national conferences. The majority of his papers regard clinical and translational research, with a particular focus on metastatic colorectal cancer. Dr Lisa Salvatore is a medical oncologist in the Department of Translational Research and New Technologies in Medicine and Surgery at the University of Pisa. She has been an author on about 40 publications in major peer-reviewed publications and has made numerous presentations in national and international conferences. Her main interest is focused on clinical and translational research in metastatic colorectal cancer
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Alfredo Pareja y Díez Canseco Manuscripts
No full textAlfredo Pareja y Díez Canseco (1908-1993) was born in Guayaquil, Ecuador. Part of the Generación del 30 and the Grupo de Guayaquil as an author, Pareja was also a university professor, Superintendent of Secondary Education, member of Ecuador's National Assembly, head of mission in the United Nations Relief and Rehabilitation Administration, ambassador of Ecuador in France and to UNESCO, and Ecuador's Minister of Foreign Relations from 1979 to 1980. He wrote a number of novels and historical texts, including El Muelle (1933), Hombres sin tiempo (1941), La Manticora (1974) and Historia del Ecuador (1954). Among numerous honors, Pareja was awarded the Medalla Premio Nacional de Cultura Eugenio Espejo and the Gran Cruz de la Orden al Mérito del Ecuador, and Spain's Gran Cruz de Isabel la Católica. His manuscript collection includes digitized manuscripts of "El Muelle" (1932), "Las Pequeñas estaturas" (1966), and "Los Poderes omnimodos" (c.1964).Digitized manuscripts of works by Ecuadorian author and historian Alfredo Pareja y Díez Canseco include "El Muelle" (1932), "Las Pequeñas estaturas" (1966), and "Los Poderes omnimodos" (c.1964).UT Librarie
Alterations of motor cortical inhibition in patients with dystonia
No full textCortical inhibitory mechanisms were investigated with the technique of paired transcranial magnetic stimulation in 10 patients with dystonia of the right arm. six patients had focal, task-specific dystonia (writer's cramp) and three had segmental and one had generalized dystonia. Paired stimuli were delivered in a conditioning-test design during slight voluntary activation of the tar-get muscle, with subthreshold conditioning stimuli at short intervals (3-20 ms) and suprathreshold conditioning stimuli al long intervals (100-250 ms). The amount of inhibition at short interstimulus intervals did not differ significantly between patients and normal subjects. With long interstimulus intervals, patients showed more inhibition of the test response, which was significant at the 150-ms interval. The cortical silent period following a single suprathreshold magnetic stimulus was slightly shorter in patients. No significant difference was detected between the affected side and the unaffected side in patients with unilateral task-specific dystonia, neither in the duration of the silent period nor in the response to paired magnetic stimuli. These results indicate that the different types of motor cortical inhibition are produced by different inhibitory circuits. We propose that the alterations observed in patients with dystonia are the result of impaired feedback from the basal ganglia to motor cortical areas, with the ultimate effect of a flattening of the excitability curve of the cortical motoneuron pool during voluntary muscle activation
Influence of electrical, chemical and morphological properties of inorganic/organic interface on light emettingdevices performance
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Cystoscopic, histopathological, molecular and clinical characterization of Interstitial Cystitis/Bladder Pain Syndrome: the MUST Trial (Multicenter interstitial cystitis/bladder pain syndrome Trial)
No full textIntroduction.
The absence of universally accepted clinical diagnostic criteria for Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS), negatively affects the progress in understanding this disease in terms of risk factors, pathogenesis, prognosis and therapy. What’s now emerging is the possible role of urinary and serum biomarkers in the diagnostic process and in the treatment of IC/BPS.
They represent a non-invasive approach to assess the inflammatory status inside the bladder.
The primary aim of our study was to evaluate the grade of correlation between cystoscopic, histopathological, molecular, and clinical data among women with IC/BPS.
The secondary aim was to compare the same data between IC/BPS patients and a cohort of women undergoing under investigation exams for other reasons.
Materials and methods.
This is an observational multicenter prospective pilot study conducted by the Division of Female Pelvic Medicine and Reconstructive Surgery of Fondazione Policlinico Universitario A. Gemelli IRCCS and of Ospedale Isola Tiberina-Gemelli Isola, Rome, Italy in collaboration with Policlinico G. Martino, Messina, Italy. Preoperative workup consists of a comprehensive medical history, physical examination, urodynamic evaluation, collection of urinary and serum samples, bladder cystoscopy with hydrodistension and bladder biopsies. Analysis of accuracy of biomarkers was determined using area under the receiver operator characteristics curve (AUC). Statistical significance was set at p<.05 (95% confidence interval). Statistical analysis was performed using the SPSS Version 26.0 for Windows (SPSS Statistics UK, SPSS Inc, Chicago, IL, USA).
Results.
Between January 2022 and June 2024 60 patients were included in the study, 30 in the IC/BPS group and 30 in the control group. IC/BPS women had a significantly lower bladder capacity and an increased bladder sensibility in comparison with the controls. IC/BPS patients showed a greater premature filling sensation and reduced bladder capacity compared to the control group. Women with lower urodynamic first desire to void (FD) had a significative higher possibility to have IC/BPS (RR 7.161, p=0.007). The comparison between non-HL-IC/BPS group and the control group didn’t reveal significant differences in bladder biopsies. We identified 4 urinary metabolic analytes capable of segregating IC/BPS women from N IC/BPS women; each of these analytes had individual AUCs greater than 0.8. When combined into a single model, the AUC was 0.917, with high sensitivity and specificity. Contrarily serum markers didn’t appear to have diagnostic power in the diagnosis of IC/BPS.
Conclusion.
Data coming from this pilot study strongly suggest that urine, but not serum, is a potential resource for screening IC/BPS women in the clinical setting. Traditional cystoscopy with bladder biopsies under anesthesia doesn’t play a significant role in discriminating IC/BPS from other similar diseases considering also the absence of correlation between inflammatory status and severity of symptoms. Nevertheless, due to the preliminary nature of the study, these results will need thorough validation
Chebyshev Collocation Method and Multi-Domain Decomposition for the Incompressible Navier-Stokes Equations
No full texthttps://doi.org/10.1002/fld.165018080
Biopolitica di Alfredo Cospito
No full textIn this article, the author analyses the case of anarchist Alfredo Cospito, in hunger strike for protesting against his carceral condition
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