1,721,158 research outputs found
Allogeneic Hematopoietic stem cell transplantation and natural killer cell alloreactivity,
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Haploidentical hematopoietic stem cell transplantation with a megadose T-cell-depleted graft: harnessing natural and adaptive immunity.
No full textFor patients with high-risk acute leukemia who do not have a matched donor or who urgently need
a transplant, transplantation from a full human leukocyte antigen (HLA) haplotype mismatched
family donor should be considered a viable option. Clinical trials have shown that a strategy for
haploidentical transplantation based on the infusion of high numbers of T-cell– depleted hematopoietic
progenitor cells and no post-transplant immunosuppression controls bi-directional T-cell
alloreactivity, ie, graft rejection and graft-versus-host disease (GvHD) in patients with leukemia.
Overall, event-free survival compares favorably with reports of transplants using sources of stem
cells other than the matched sibling. This transplant modality has highlighted the crucial role of
donor-versus-recipient natural killer cell (NK) alloreactivity in the control of leukemia relapse.
Current studies are focusing on rebuilding post-transplant immunity to improve clinical outcomes
Amneris Roselli & Roberto Velardi (a cura di), L’insegnamento delle technai nelle culture antiche. Atti del Convegno. Ercolano, 23-24 marzo 2009. Pise-Rome, Fabrizio Serra, 2011
No full textFederspiel Michel. Amneris Roselli & Roberto Velardi (a cura di), L’insegnamento delle technai nelle culture antiche. Atti del Convegno. Ercolano, 23-24 marzo 2009. Pise-Rome, Fabrizio Serra, 2011. In: L'antiquité classique, Tome 81, 2012. pp. 388-389
Amneris Roselli & Roberto Velardi (a cura di), L’insegnamento delle technai nelle culture antiche. Atti del Convegno. Ercolano, 23-24 marzo 2009. Pise-Rome, Fabrizio Serra, 2011
No full textFederspiel Michel. Amneris Roselli & Roberto Velardi (a cura di), L’insegnamento delle technai nelle culture antiche. Atti del Convegno. Ercolano, 23-24 marzo 2009. Pise-Rome, Fabrizio Serra, 2011. In: L'antiquité classique, Tome 81, 2012. pp. 388-389
Concetti e categorizzazione dei disturbi mentali. Come la psicologia cognitiva può aiutare la psichiatria
No full textL’ipotesi che guida il presente contributo è che uno dei modi per migliorare l’utilità clinica sia rendere il formato della nosologia quanto più simile possibile al modo in cui i clinici categorizzano i pazienti – cioè fanno diagnosi –, nell’ambito del rispetto dei vincoli di validità e coerenza interna. In psicologia sperimentale ci sono ricerche in corso sul modo di rappresentare concettualmente i disturbi mentali da parte dei clinici (cioè esperti) nella pratica e in contesti di laboratorio. In questo breve articolo ne illustrerò una parte, suggerendo un possibile utilizzo a miglioramento dell’utilità clinica della nosologia psichiatrica corrente
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
HYALURONIC ACID TRIGGERS EFFECTOR FUNCTIONS OF T-CELLS AND BINDS WITH THE CD44 OF ACTIVATED T-CELLS
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