3,405 research outputs found
Rilievo e ricostruzione virtuale della Chiesa di S. Antonio a Poggioreale Vecchia – Trapani
No full textLe attività relative alla Chiesa di S. Antonio a Poggioreale Vecchia, si inseriscono in un più ampio progetto che la Regione Sicilia ha da tempo avviato a cura del Centro Regionale per la Progettazione e il Restauro (C.R.P.R.) e che prevede la redazione di una Carta Regionale del Rischio.
La rilevanza del sito di Poggioreale vecchia risiede da un lato nella particolare situazione in cui si è venuto a trovare l'abitato a seguito del sisma che nel 1968 ha devastato l'area del Belice e che nello specifico ha determinato l’abbandono dell'edificato storico e lo spostamento del nuovo insediamento urbano in un'area ritenuta più sicura; dall’altro nell'attuale condizione di abitato demanializzato e ormai archeologizzato.
All’interno del progetto generale, la presente ricerca si pone come obiettivo la conoscenza dettagliata di un singolo elemento, la Chiesa di S. Antonio, come entità “prototipo” di una realtà urbana estremamente significativa, al fine di poter successivamente definire criteri e obiettivi di un recupero ambientale e di una riqualificazione urbana correlati alla mitigazione dei vari fattori di rischio.
Sono stati eseguiti: rilievi mediante scansione Laser 3D (Leica HDS 3000) e stazione totale, con realizzazione di elaborati bidimensionali con rappresentazione della pianta a curve di livello e i relativi prospetti e sezioni; studio dell’ordine architettonico del pronao (base e capitello) con analisi delle sezioni e realizzazione delle superfici; realizzazione di modello completo 3D texturizzato della Chiesa, completo di database gestionale per il controllo ed ottimizzazione dello stesso, con particolare attenzione alle trasformazioni dalla nuvola di punti alle superfici Mesh e NURBS, per rappresentazione interattiva via internet grazie alla tecnica del 3D Browsing
La Biblioteca diocesana di Lugano. Primi passi di una storia tutta da scoprire
No full textLuca Montagner apre la sezione Contributi della Rivista con un saggio sulla storia della Biblioteca diocesana di Lugano, entrata in tempi recenti nel Sistema bibliotecario ticinese ed erede della vecchia Biblioteca del Seminario, il cui fondo più antico risale al Seminario ambrosiano di Pollegio, istituito nel 1622
La ricomposizione del paesaggio collinare. La stazione a monte della vecchia funivia Bologna - San Luca.
No full textQuesta tesi tratta il tema dell'intervento sull'esistente, non tanto in termini di recupero quanto di ricomposizione, dimostrando come tale approccio sia più indicato in ben determinate situazioni. La ricomposizione del dismesso comporta innumerevoli vantaggi per quanto riguarda il consumo di suolo ma anche la possibilità di intervenire in modo più vario e deciso, sempre nel massimo rispetto del contesto.
L'obiettivo di questo progetto è di dimostrare come la ricomposizione, nel particolare caso della stazione a monte della vecchia funivia Bologna - San Luca, possa portare all'ulteriore valorizzazione di un contesto già "ricco" paesaggisticamente e culturalmente. Questo avviene passando attraverso lo studio e la ricerca di un morfema compositivo in totale coerenza col paesaggio. Lo studio degli spazi percorre un iter preciso, che parte dallo studio del Raumplan di Adolf Loos passando per la sue evoluzioni e rivisitazioni critiche (in particolare la "traiettoria" di Rem Koolhaas) dando corpo all'innovativo concetto di Urban Room (Mossessian Architecture) al fine di creare un'ambiente di stimoli e condivisione per la comunità
An assessment of the impact of possible CAP reform scenarios on Romanian agriculture
No full textUsing a simplified model, with key-variable the prices of two different possible scenarios of CAP reform after 2013 (moderate and radical), this paper present a comparison between the price effects of implementation of each reform scenario at 2015 horizon on Romanian agriculture. This short analysis shows that, under the presented hypotheses, the net welfare effect, due to the price changes, for the selected products, is positive in both reform scenarios, yet greater in the case of the radical reform. Integrated in the large context of Romanian development, it seems that the influence of CAP reform upon agriculture and rural areas will be most likely a gradual one: an interpenetration between the two scenarios is foreseeable, starting with the moderate reform that will dominate the period around 2013, the reform measures acquiring a more radical character afterwards.CAP reform, Romania, welfare effects, Agricultural and Food Policy,
Effects of curing on the hydro-mechanical behaviour of cement-bentonite mixtures for cut-off walls
No full textCement-bentonite cut-off walls are commonly employed in geoenvironmental applications to limit ground water flow and pollutant transport. The wide diffusion of this artificial material in the current practice is not only due to its low permeability, but also to its simplicity of use. In this paper, experimental evidences about the role of curing on the hydro-mechanical behaviour of cement-bentonite mixtures are presented. Different curing times and curing conditions (representative for either water saturated or hydrocarbon polluted soils) have been considered, and their effects on both hydraulic conductivity and mechanical response in oedometer and triaxial conditions have been assessed. A unified hydro-mechanical framework, accounting for the changes of material fabric occurring with curing time and environment, is formulated. The hydraulic conductivity is very well predicted by a Kozeny-Carman like equation, whereas the mechanical behaviour is finely reproduced via an enhanced elastic–plastic constitutive model.</p
Rich, Sturmian, and trapezoidal words
No full textIn this paper we explore various interconnections between rich words, Sturmian words, and trapezoidal words. Rich words, first introduced by the second and third authors together with J. Justin and S. Widmer, constitute a new class of finite and infinite words characterized by having the maximal number of palindromic factors. Every finite Sturmian word is rich, but not conversely. Trapezoidal words were first introduced by the first author in studying the behavior of the subword complexity of finite Sturmian words. Unfortunately this property does not characterize finite Sturmian words. In this note we show that the only trapezoidal palindromes are Sturmian. More generally we show that Sturmian palindromes can be characterized either in terms of their subword complexity (the trapezoidal property) or in terms of their palindromic complexity. We also obtain a similar characterization of rich palindromes in terms of a relation between palindromic complexity and subword complexity
Mechanical Behavior and Constitutive Modeling of Cement–Bentonite Mixtures for Cutoff Walls
No full textCement–bentonite mixtures are commonly used to build cutoff walls, which limit water flow and underground transport of pollutants. These artificial materials are employed due to their very low permeability and adequate shear strength and ductility. In this paper, experimental results about the microstructure and mechanical behavior of three different cement–bentonite mixtures are presented. Specimens of these mixtures were subjected to oedometer and consolidated-undrained triaxial tests. These results were then used as a basis for the definition of a suitable constitutive framework. A quite good reproduction of the experimental results up to the peak strength was obtained
using the classical Modified Cam Clay model, which could then be used satisfactorily when conventional analyses aimed at assessing the stability of cutoff walls are required. The reproduction of the strength degradation and the strains occurring in the postpeak stage requires, however, a more advanced constitutive model. To this extent, the Modified Cam Clay framework was enhanced by introducing some features commonly employed to reproduce the mechanical behavior of granular materials. This model may be useful for the real-scale analysis of more critical cases when local failure mechanisms are likely to occur and may influence the functionality of the wall
Activin Receptor-Like Kinase 1: a novel anti-angiogenesis target from TGF-β family.
No full textAnti-angiogenic therapy represents a very promising approach in cancer treatment, as most tumors needs to be supplied by a functional vascular network in order to grow beyond the local boundaries and metastatize. The accessibility of vessels to drug delivery and the broad spectrum of cancers treatable with the same compound have arisen interest in research of suitable molecules, with several, especially targeting the VEGF pathway, entered in clinical trials and approved by Food and Drug Administration. Despite good results, the major hurdle resides in the limited duration of an effective clinical response before tumors start to grow again. Thus, researchers are looking for different alternative targets for a combined and parallel multi-targeting of angiogenic signaling circuits. Activin Receptor-like kinase 1 (ALK1) is a TGF-β type I receptor with high affinity for the BMP9 member of Bone Morphogenic Proteins superfamily: it is expressed mainly, even if not exclusively, on endothelial cells and seems to be involved in the regulatory phase of angiogenesis. Despite a not completely elucidated mechanism, the targeting of this pathway, both by a soluble ALK1-Fc receptor developed by Acceleron Pharma and by a fully human monoclonal antibody developed by Pfizer, has achieved encouraging results. After having briefly summarized the state of the art of anti-angiogenic therapy, we will first review existing evidence about the molecular mechanisms of ALK1 signaling and we will then analyse in detail the pre-clinical and clinical data available about these two drugs
Antibody-drug conjugates: targeted weapons against cancer
No full textAntibody drug conjugates (ADCs) are formed by a targeting antibody conjugated to a chemotherapeutic molecule through a linker. Recent data demonstrate that they represent a valuable advancement for the clinics and, despite their recent appearance, they are already undergoing an innovation wave aimed at targeting all their three building blocks. Thus, new antibody formats are being engineered, site-specific linkers are being designed and highly toxic molecules, like RNA polymerase inhibitors, start to be used for conjugation. These molecules were previously considered extremely toxic and could not be used as chemotherapeutic drugs. In this review, we will go through an overview of current cancer treatments and their limitations, and the logic which has led to the generation of ADCs. Their mechanism of action will be outlined and the most recent novelties in linker design and optimization will be discussed, along with present and near future of the current ADC pipeline
- …
