1,720,965 research outputs found
Aspetti neuroendocrini della terapia termale. Esperienze in corso di terapia inalatoria con acqua salso-bromo-iodica di Salsomaggiore Terme
No full textEffetti della crenoterapia con acqua salsobromoiodica di Salsomaggiore sull’asse ipotalamo-ipofisi-ovaio in donne normali in periodo climaterico
No full textEffetti della crenoterapia con acqua salsobromoiodica di Salsomaggiore sull’asse ipotalamo-ipofisi-ovaio in donne normali in periodo climaterico
No full textThe therapy of gynaecological diseases with salty mineral water: a branch of the "Naiade Project"
No full textEffects of a gynaecological thermal treatment on the hypothalamic-pituitary ovarian axis in premenopausal women.
No full textValutazione degli ormoni regolatori del metabolismo osseo durante balneoterapia con acqua salsobromoiodica di Salsomaggiore in donne in menopausa
No full text: Evaluation of bone metabolism regulating hormones during treatment with salty bromo iodic baths in menopausal women.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Respicell(TM): An innovative dissolution apparatus for inhaled products
Full text linkTo overcome some of the shortfalls of the types of dissolution testing currently used for pulmonary products, a new custom-built dissolution apparatus has been developed. For inhalation products, the main in vitro characterisation required by pharmacopoeias is the deposition of the active pharmaceutical ingredient in an impactor to estimate the dose delivered to the target site, i.e., the lung. Hence, the collection of the respirable dose (<5 μm) also appears to be an essential requirement for the study of the dissolution rate of particles, because it results as being a relevant parameter for the pharmacological action of the powder. In this sense, dissolution studies could become a complementary test to the routine testing of inhaled formulation delivered dose and aerodynamic performance, providing a set of data significant for product quality, efficacy and/or equivalence. In order to achieve the above-mentioned objectives, an innovative dissolution apparatus (RespiCellTM) suitable for the dissolution of the respirable fraction of API deposited on the filter of a fast screening impactor (FSI) (but also of the entire formulation if desirable) was designed at the University of Parma and tested. The purpose of the present work was to use the RespiCell dissolution apparatus to compare and discriminate the dissolution behaviour after aerosolisation of various APIs characterised by different physico-chemical properties (hydrophilic/lipophilic) and formulation strategies (excipients, mixing technology)
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