1,721,193 research outputs found
What is up? Testing spectral heterogeneity versus NDVI relationship using quantile regression
No full textOncolytic Viruses in the Era of Omics, Computational Technologies, and Modeling: Thesis, Antithesis, and Synthesis
Full text linkOncolytic viruses (OVs) are the frontier therapy for refractory cancers, especially in integration with immunomodulation strategies. In cancer immunovirotherapy, the many available "omics" and systems biology technologies generate at a fast pace a challenging huge amount of data, where apparently clashing information mirrors the complexity of individual clinical situations and OV used. In this review, we present and discuss how currently big data analysis, on one hand and, on the other, simulation, modeling, and computational technologies, provide invaluable support to interpret and integrate "omic" information and drive novel synthetic biology and personalized OV engineering approaches for effective immunovirotherapy. Altogether, these tools, possibly aided in the future by artificial intelligence as well, will allow for the blending of the information into OV recombinants able to achieve tumor clearance in a patient-tailored way. Various endeavors to the envisioned "synthesis" of turning OVs into personalized theranostic agents are presented
What is up? Testing spectral heterogeneity versus NDVI relationship using quantile regression
No full textConservation between the RNA polymerase I, II, and III transcription initiation machineries
Full text linkRecent studies of the three eukaryotic transcription machineries revealed that all initiation complexes share a conserved core. This core consists of the RNA polymerase (I, II, or III), the TATA box-binding protein (TBP), and transcription factors TFIIB, TFIIE, and TFIIF (for Pol II) or proteins structurally and functionally related to parts of these factors (for Pol I and Pol III). The conserved core initiation complex stabilizes the open DNA promoter complex and directs initial RNA synthesis. The periphery of the core initiation complex is decorated by additional polymerase-specific factors that account for functional differences in promoter recognition and opening, and gene class-specific regulation. This review outlines the similarities and differences between these important molecular machines
Principali malattie Crittogamiche del Castagno
No full textUna tra le più gravi malattie parassitarie del Castagno a livello mondiale è il Cancro della corteccia. Questa fitopatia, d’origine asiatica, fu segnalata per la prima volta nel 1904 nello Stato di New York ed attribuita a Diaporthe parasitica (Murril,1906), successivamente chiamata Endothia parasitica (Anderson e Anderson, 1912) ed oggi Cryphonectria parasitica (Murr.) Barr. Sebbene l’incidenza del cancro sia altissima nei castagneti Italiani, la severità della malattia si mantiene molto bassa grazie alla diffusione dell’ipovirulenza esclusiva associata all’infezione di Hypovirus. Il mal dell’inchiostro è attualmente la malattia più pericolosa per il Castagno e la sua diffusione nei castagneti Europei è favorita dal graduale aumento delle temperature e dall’intensificarsi di eventi meteorici estremi. Gli agenti principali del mal dell’inchiostro sono due specie appartenenti al genere Phytophthora. In Italia per più di un secolo e fino al 1985 l’unica specie presente era la Phytophthora cambivora, poi in un castagneto della provincia di Latina è stata ritrovata anche la P. cinnamomi, potenzialmente molto più pericolosa perché in grado di attaccare oltre 800 specie vegetali (Cristinzio, 1986). Contro questa malattia presso la Facoltà di Agraria di Portici si sta mettendo a punto un metodo di controllo biologico, utilizzando sostanze purificate da un ceppo di Aspergillus flavus, isolato in un castagneto in provincia di Caserta, che ha mostrato attività antagonista contro le Phytophthora. In centro Italia (Lazio e Marche) l’Università della Tuscia sta sperimentando con successo l’applicazione di protocolli di lotta integrata al mal dell’inchiostro che includono la sistemazione idraulica dell’area infestata, interventi di endoterapia con fosfito di potassio e trattamenti localizzati con prodotti di sintesi e solfato di rame. Il castagno è suscettibile ad un numero di malattie minori: la Fersa del Castagno, malattia fogliare causata da fungo Mycosphaerella maculiformis (Pers.:Fr.) J.Schröt; l’oidio, da Microsphaera quercina f.c. Oidium quercinum; le necrosi corticali causate da Diplodina castaneae Prill & Delacr , Amphyporthe castanea (Tul.) e Melanconis modonia Tul.; il Marciume Radicale Fibroso causato da Armillaria mellea (Vahl:Fr.) P. Kumm. e A. gallica Marxmüller et Romagnesi. Tra gli agenti di carie del legno ricordiamo Fistulina hepatica, agente di carie bruna e i generi Stereum, Fomes, Polyporus e Schizophyllum Per quanto riguarda le malattie del frutto, il marciume nero, causato da Sclerotinia pseudotuberosa Rehm. (syn Ciboria batschiana (Zopf) Buchw., anamorph Rhacodiella castaneae Pyr.), è sicuramente la causa maggiore di perdita di produzione e qualità in post raccolta. La recente scoperta dell’attitudine del fungo a vivere come endofita in tessuti sani del castagno e la sua associazione con il balanino hanno contribuito a meglio comprendere l’epidemiologia della malattia su castagno. Altri miceti causano danni più o meno rilevanti sul frutto: Phomopsis endogena (Speg.), agente della mummificazione delle castagne, e vari altri agenti di muffe quali Penicillum spp., Mucor spp., Aspergillus spp., Amphiporthe castanea, e Trichothecium roseum
Diario di prigionia del sottotenente Martino Bardotti. Internato militare settembre 1943- dicembre 1944
No full textvol. n. 8 collana PAROLE DI GUERR
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Targeting of Regulators as a Promising Approach in the Search for Novel Antimicrobial Agents
Full text linkSince the discovery of penicillin in the first half of the last century, antibiotics have become the pillars of modern medicine for fighting bacterial infections. However, pathogens resistant to antibiotic treatment have increased in recent decades, and efforts to discover new antibiotics have decreased. As a result, it is becoming increasingly difficult to treat bacterial infections successfully, and we look forward to more significant efforts from both governments and the scientific community to research new antibacterial drugs. This perspective article highlights the high potential of bacterial transcriptional and posttranscriptional regulators as targets for developing new drugs. We highlight some recent advances in the search for new compounds that inhibit their biological activity and, as such, appear very promising for treating bacterial infections
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