124,685 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
The C-terminal domain of yeast Ero1p mediates membrane localization and is essential for function
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The C-terminal domain of yeast Ero1p mediates membrane localization and is essential for function
No full textAbstractIn eukaryotes, members of the Ero1 family control oxidative protein folding in the endoplasmic reticulum (ER). Yeast Ero1p is tightly associated with the ER membrane, despite cleavage of the leader peptide, the only hydrophobic sequence that could mediate lipid insertion. In contrast, human Ero1-Lα and a yeast mutant (Ero1pΔC) lacking the 127 C-terminal amino acids are soluble when expressed in yeast. Neither Ero1-Lα nor Ero1pΔC complements an ERO1 disrupted strain. Appending the yeast C-terminal tail to human Ero1-Lα restores membrane association and allows growth of ERO1 disrupted cells. Therefore, the tail of Ero1p mediates membrane association and is crucial for function
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
Study on the Pteridines Metabolism in Children Affected by Hyperphenylalaninaemia and Phenylketonuria
No full textAtypical phenylketonuria (PKU) is caused by tetrahydrobiopterin (BH4) deficiency. In Italy a systematic screening service for BH4 deficiency is not currently performed, therefore its real frequency is not known yet. We determined urinary excretion of biopterin (B) and neopterin (N) by HPLC in 74 phenylketonuric and hyperphenylalaninemic subjects, including all newborns with positive Guthrie's test for PKU since 1984. We found two patients with N and B urinary values above the classical PKU range. In these subjects we also performed a BH4 loading test that restored a normal plasma phenylalanine level in one case, while it had no effect in the other one. In both of them, the enzymatic activity of dihydropteridine reductase on dried blood spots was absent. We conclude that the determination of urinary pteridines together with the BH4 loading test are useful and informative tools in the screening of BH4 deficiencies, but that a conclusive diagnosis can only be achieved by the enzymatic assays
Dr. Edwin Wright Collection: Author Unknown
Get PDFNotes - The author relates several short stories about his neighbours including Alex McDonell, homesteading and life around Meanook and Athabasca (1 page
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Synthesis and Biological Evaluation of a New RGD-Camptothecin Conjugate Bearing a Cathepsin B-Sensitive Linker
No full textIntegrins are a large family of heterodimeric transmembrane glycoprotein receptors, composed by two non-covalently associated subunits (α and β). Integrins αVβ3 and αVβ5 have been found to be overexpressed on blood vessels in human tumors, but not on vessels in normal human tissues. For this reason, these integrins have become attractive targets for pharmacological studies mainly in the oncology area.
The Gennari and Piarulli group recently developed a peptidomimetic compound containing the RGD (Arg-Gly-Asp) sequence and a diketopiperazine (DKP) scaffold as powerful αvβ3 integrin ligand (compound 1).1,2 This ligand was linked to Camptothecin through the Phe-Leu-Gly peptide sequence: a well-known cathepsin B-sensitive linker.3
The RGD-Drug conjugate 2 was examined in vitro for its ability to compete with biotinylated vitronectin for binding to the purified αVβ3 and αVβ5 receptors (Figure 1a). This tests showed that 2 can bind the αVβ3 integrin with high affinity (low nanomolar IC50 values). Compound 2 was subjected to stability assays in the presence of cathepsin B and lysosome extract, revealing that the free Camptothecin is efficiently released under these conditions. The antiproliferative activity of compound 2 has been evaluated against CEM-D9 (αVβ3 +) and CEM (αVβ3 ) cell lines. A higher activity of the RGD-drug conjugate 2 is shown towards the high αVβ3-expressing cell line CEM-D9 (Figure 1b). We gratefully acknowledge MIUR for financial support (PRIN project 2010NRREPL: Synthesis and Biomedical Applications of Tumor-Targeting Peptidomimetics)
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