1,724,102 research outputs found
Intraoperative sentinel node detection by an innovative imaging probe.
No full textIntraoperative sentinel node detection by an innovative imaging probe.
Campisi C, Soluri A, Stella S, Valenti G, Scopinaro F.
SourceInstitute of Biomedical Technologies, National Research Council, Rome. [email protected]
Abstract
Intraoperative tumor detection has been used in many applications, and today the sentinel node technique is a widely employed surgical procedure in breast cancer. Different detector systems are employed but several problems have been reported in clinical practice, in particular the difficulty to accurately detect the sentinel node within the axillary soft tissue. The problem is even greater for abdominal and thoracic tumors. We propose an innovative Imaging Probe (IP) able to visualize on a monitor the primary tumor and secondary lesions if appropriately radiolabeled. The IP can be optimally applied for minimally invasive surgery in breast cancer treatment, and a preliminary experience related to 15 patients and 20 sentinel nodes is reported here. We compared the results obtained with the IP to those obtained with an Anger camera and a traditional scintillation detector, and found them to be very promising. In particular the surgeon's work is greatly facilitated by direct visual guidance instead of a generic acoustic signal.
PMID:12369557[PubMed - indexed for MEDLINE
Adrenopausa: una sindrome clinica da squilibrata secrezione di deidroepiandrosterone e cortisolo
No full text
Urban-scale macroscopic fundamental diagram: An application to the real case study of Rome
No full textThe paper investigates a recent and attractive concept in traffic modeling: the urban-scale Macroscopic Fundamental Diagram (MFD), which is able to link space-mean flow, density and speed in an urban area. Specifically, it explores the possibility to derive the diagram for the complex city context of Rome, Italy, in order to give some guidelines for using MFD in traffic management and control applications. To this aim, the study uses real data, specifically loop detectors and floating car data related to May 2013. Results adopting real data confirm what was obtained in previous studies, such as low scatter in the data points generating the MFD and the hysteresis phenomenon linked with the heterogeneity of traffic patterns and congestion. Some criticalities have been also underlined when deriving the MFD from real data. They are mainly due to the spatial and temporal coverage of the information. Finally, a simulation approach based on the dynamic traffic assignment has been tested as mimicking the presence of loop detectors over the entire road network. The urban-scale MFD resulting from the simulation has been adopted as the leading model to forecast the evolution of traffic inside a monitored area and, consequently, define the traffic management actions to be taken. © 2017, Aracne Ed. All rights reserved
Subcritical Turing patterns in hyperbolic models with cross–diffusion
No full textThis paper focuses on the role of hyperbolicity on pattern formation in the subcritical regime for a class of hyperbolic models with cross-diffusion. A weakly nonlinear analysis up to the fifth order is employed to describe the time evolution of the pattern amplitude close to the instability threshold. The effects of the inertial times on the pattern formation as well as on the transient subcritical regime are investigated, both analitically and numerically, in the case of the hyperbolic Schnakenberg model
Misurare la soddisfazione lavorativa: costruzione di uno strumento di indagine multidimensionale
Full text linkBackground: Although numerous studies have been done on the topic of job satisfaction, as regards the Italian research, the construction of specific psychometric instruments is lacking. Objectives: The present paper is aimed to develop a scale to measure job satisfaction referring to our cultural context. Methods: Participants were 222 workers (36.5% males, 635% females) with an average age of 3839 years (SD = 10.91). The formulated items were selected from a large item pool on the basis of the evaluation by a group of expert judges, and the item analysis procedure. In order to establish test validity, the following instruments were also administered: Occupational Stress Indicator, Satisfaction With Life Scale, Rosenberg Self-Esteem Scale, Multidimensional Scale of Perceived Social Support, and Beck Depression Inventory. Results: Both exploratory and confirmatory factor analyses highlighted a 6-factor structure. Those factors were responsible for 51.30% of the total variance. Reliability analyses indicated satisfying internal consistency (ranging from a =.73 to a =.86). Construct validity was supported by results obtained calculating correlations with the theoretically associated variables. Conclusions: Our findings suggest promising psychometric properties for the presented measure. The instrument could be used in specific programs developed to promote well-being conditions in work settings
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Effects of cimetidine on the secretion of some pituitary hormones
No full textCimetidine infused intravenously into 6 healthy volunteers did not induce significant changes in plasma levels of prolactin (hPRL), thyreotropin (hTSH), gonadotropin (hLH and hFSH) and growth hormone (hGH). Conversely it caused a significant increase in prolactin response to TRH without modifying the hTSH response to thyreotropin-releasing hormone (TRH) and gonadotropin response to gonadotropin-releasing hormone (GnRH). Data obtained in these experiments, together with data reported in the literature, suggest that the amplified prolactin response to TRH observed during cimetidine infusion, is likely to be connected with a blockade of H2-receptors rather than to unspecific actions of cimetidine
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