811 research outputs found
Musculocutaneous latissimus dorsi free transfer flap for total phalloplasty in children
No full textObjective: Total phalloplasty is rarely performed in children due to the mutilation involved and the dilemma concerning neophallic size in children. We present a musculocutaneous latissimus dorsi free transfer flap for total phalloplasty in children with difficult psychological problems. Materials and methods: Total phalloplasty was performed in eight boys aged between 10 and 15 years. Indications were small penis after failed epispadias repair (4), micropenis (3) and intersexuality (1). A musculocutaneous latissimus dorsi free flap was harvested with thoracodorsal artery, vein and nerve. The flap was transferred to the pubic region and anastomosed to the femoral artery, saphenous vein and ilioinguinal nerve. Two-staged urethroplasty was performed in five patients using buccal mucosa, while in the remaining three a Mitrofanoff channel had been created previously. An inflatable penile prosthesis was implanted in two cases after puberty. Results: Follow-up was from 6 to 53 months (mean: 29 months). Penile size varied from 13 to 16 cm in length and from 10 to 12 cm in circumference. No flap necrosis, either partial or total, was noted. The donor site healed acceptably in four cases while in the remaining four moderate scarring occurred. Function of the penile prostheses is satisfactory. Psychological status is significantly improved in all children. Conclusion: Phalloplasty in childhood is indicated to prevent profound psychological problems related to body dysmorphia. The musculocutaneous latissimus dorsi flap is a possible choice for phalloplasty in children that enables good neophallic size as in adults. We recommend this surgery to be performed before puberty to ensure optimal psychosexual pubertal development. © 2006 Journal of Pediatric Urology Company
Exploring the impact of nursing students’ program experiences on post-graduation career specialty choices
No full textThis poster won the Dean, Faculty of Health Sciences Award (2021).
Advisor: Dr. Shelley Canning, Faculty of Health Sciences
PENILE RESCULPTURING IN SURGERY OF M. PEYRONIE: RESTORATION OF PENILE LENGTH, GIRTH AND SHAPE WITH OR WITHOUT PENILE PROSTHESIS IMPLANTATION
No full textInnovation Success and Failure: The Moderating Role of Marketing Innovation
No full textInnovation is increasingly attracting attention by public authorities, firms and academics. Academic research has largely focused on the role of technological innovation in driving firm performance. Although there is emerging evidence that marketing innovation should regarded as important as technological innovation for enhancing companies’ competitiveness, few studies have taken it into account (Medrano and Olarte-Pascual 2016). The present study aims at addressing this gap by examining the moderating role of marketing innovation in the relationship between technological innovation and innovation success - the share of turnover related to technological innovation - and failure - the abandoning of an innovation. This study performs an analysis on a sample of German CIS firms related to the 2010-2012 period by means of a double hurdle model and a probit model with sample selection. Results show that introducing a marketing innovation does not play a significant role as far innovation success and failure are concerned. However, when the four types of marketing innovations are disentangled in the analysis, innovations in product packaging and design and in product promotion are found to moderate, respectively, positively and negatively the relationship between technological innovation and innovation success. Firms should then carefully evaluate which marketing innovation should be selected to leverage innovation success in the short run
Allergenicity and immunogenicity of the major mugwort pollen allergen Art v 1 chemically modified by acetylation
No full textTreating allergies with modified allergens is an approach to make the treatment safer and more efficient. Art v 1 is the most prominent allergen of mugwort pollen and a significant cause of hayfever around Europe. The aim of this study was to reduce the allergenicity of Art v 1 by acetylation, and to investigate the capacity of the modified protein to generate blocking antibodies. The reduction of allergenicity of Art v 1 following acetylation was monitored by immunoblot, ELISA inhibition using a pool of sera from mugwort pollen allergic patients, basophil activation assay and by skin prick testing of mugwort-allergic patients. Rabbits were immunized against Art v 1 and acetylated Art v 1 (acArt v 1) and the rabbit antisera were tested for their capacity to block human IgE binding in ELISA. Human T cell proliferation against Art v 1 and acArt v 1 was examined in peripheral blood mononuclear cells (PBMCs) of mugwort pollen allergic patients and cytokine release in PBMC cultures was monitored. Acetylation of Art v 1 gave a derivative of reduced allergenicity in the in vitro and ex vivo tests applied. The skin test reactivity to acArt v 1 was significantly reduced in 19 patients when compared with the reactivity to Art v 1. Rabbit antibodies to acArt v 1 and Art v 1 showed similar capacity to block human IgE binding to Art v 1 in inhibition ELISA. Both proteins were able to induce proliferation of PBMCs and CD3/CD4(+) cells of mugwort-allergic patients. Release of IL-5 was significantly reduced in cultures stimulated with acArt v 1. Art v 1 modified by acetylation had a significantly reduced allergenicity in vitro and in vivo, while its immunogenicity was retained. Modification of allergens by acetylation could be a new strategy for allergen-specific immunotherapy. Cite this as: I. Perovic, M. Milovanovic, D. Stanic, L. Burazer, D. Petrovic, N. Milcic-Matic, G. Gafvelin, M. van Hage, R. Jankov and T. Cirkovic Velickovic, Clinical and Experimental Allergy, 2009 (39) 435-446
Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors
No full textHIV-1 integrase (IN) is an essential enzyme for viral replication and represents an intriguing target for the development of new drugs. Although a large number of compounds have been reported to inhibit IN in biochemical assays, no drug active against this enzyme has been approved by the FDA so far. In this study, we report, for the first time, the use of the electron-ion interaction potential (EIIP) technique in combination with molecular modeling approaches for the identification of new IN inhibitors. An innovative virtual screening approach, based on the determination of both short- and long-range interactions between interacting molecules, was employed with the aim of identifying molecules able to inhibit the binding of IN to viral DNA. Moreover, results from a database screening on the commercial Asinex Gold Collection led to the selection of several compounds. One of them showed a significant inhibitory potency toward IN in the overall integration assay. Biological investigations also showed, in agreement with modeling studies, that these compounds prevent recognition of DNA by IN in a fluorescence fluctuation assay, probably by interacting with the DNA binding domain of IN
Consumo de alimentos fuente de quercetina y factores de riesgo en enfermedades cardiometabólicas.
No full textTrabajo de Investigación para la Licenciatura en Nutrición.Introducción: Estudios científicos demuestran que los fenoles, entre ellos la quercetina,
presentes en los alimentos naturales, protegen contra la aparición de las enfermedades
cardiometabólicas (ECM) por su función antioxidante.
Objetivo: Determinar la relación entre quercetina, fenoles y alimentos fuente con
factores de riesgo de ECM.
Metodología: Estudio descriptivo, correlacional y transversal. Participaron 123
personas, mayores de 35 años asistentes al Servicio de Cardiología del HNC. Fueron
administradas encuestas validadas para evaluar la ingesta de alimentos, actividad física
y hábito tabáquico, y se consideraron medidas antropométricas, tensión arterial y
determinaciones bioquímicas. Se utilizó el programa Interfood v.1.3 para estimar el
consumo de nutrientes y fitoquímicos y, para el análisis de datos, el Stata v.11. Se
aplicaron test T, Fisher, Chi Cuadrado y Spearman.
Resultados: El 80% de los participantes presentó exceso de peso, 90% riesgo
cardiovascular, 63% hipertensión y 27% diabetes.
Se observó diferencia estadísticamente significativa en el diagnóstico de índice de masa corporal, presión sistólica, presión diastólica, colesterol, HDL-c, VET y alcohol según sexo. El consumo de quercetina fue de 496,32 mg/día, fenoles 80,44 g/día, alimentos fuente de quercetina 508,84 g/día y frutas y verduras 970,01 g/día; no se observaron diferencias
estadísticamente significativas según sexo, (p>0,05). No se encontraron correlaciones
entre las variables alimentarias y factores de riesgo cardiometabólicos.
Conclusión: Si bien no se hallaron asociaciones entre el consumo de quercetina, fenoles
y sus alimentos fuente con factores de riesgo en ECM, es necesario continuar con
investigaciones sobre estos compuestos bioactivos
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Legal Strategies and Global Synergies: Expanding the Legacy of Brown v. Board for Educational Equity
No full textThis article examines the enduring legacy of Brown v. Board of Education within a global framework, emphasizing its profound role in advancing racial justice and educational equity. By juxtaposing the struggles of African Americans in the United States and the Roma in Europe, the article highlights the necessity of an integrated approach that combines legal advocacy, grassroots activism, and international cooperation. It explores the transnational migration of legal norms and strategies, uncovering the dynamics of adaptation and contestation across different socio-legal landscapes. Furthermore, the article addresses the challenges of transforming legal victories into substantive social change, demonstrating the complex relationships between legal systems, societal norms, and political dynamics. Recognizing the persistent educational disparities faced by marginalized communities worldwide, it advocates for a holistic approach that merges legal reform, policy innovation, and community mobilization to advance racial justice and educational equity globally. By advocating for a nuanced understanding of legal activism within a broader strategy for social transformation, the article highlights the essential role of a comprehensive approach in promoting racial justice and educational equity worldwide
Freud on Writing: Some Historicist Perspectives
No full textThe author looks at three readings of Freud by Derrida, Michel de Certeau, and Deleuze/Guattari, trying to answer the question: For Freud, how does writing produce meaning and what does this historicizing function imply about the psyche in general? The author inspects two of Freud’s analogies that are to explain and justify psychoanalysis: books avoiding political censorship and the mystic writing pad. These become doorways to the ensuing criticisms. The three commentaries trace sections of Freud’s thought as they relate to his fundamental concepts and to the work those concepts are supposed to do. Read together, the readings each supply support for the conclusion that Freud illegitimately treats the unconscious as the first cause, tied as he is to the metaphysics of presence. Freud’s psychoanalyst, in the name of nothingness, makes real his historicizing of the unconscious. Freud’s thought betrays his thought
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