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Ferritin and Transferrin Receptor 1: cryo-EM structural studies and protein engineering
Get PDFThe principal aim of this thesis is the structural determination of the residues involved in the complex between the human Ferritin H-chain (HFt) and the human Transferrin Receptor 1 (hTfR1 or CD71) at near to atomic resolution.
HFt nanoparticles represent one of the most appropriate vectors for cellular delivery of molecules thanks to their internalization by CD71, a transmembrane receptor overexpressed in most cancer cell types. As such, literature is continuously enriched by successful biomedical applications of this interaction; nevertheless, the epitopes of their recognition are to date unknown. To this end, we exploited single-particle cryo-electron microscopy (cryo-EM): this technique is currently under intense technological development and can now be used as a convenient method to determine atomic structures of protein complexes. So, we took advantage of modern cryo-electron microscopes and GPU-equipped computer clusters for single particle analysis calculations. Through the CD71-targeted distribution of specific payloads, the cellular internalization property of HFt might be used for a plethora of purposes, ranging from anticancer therapy to image-enhancement for diagnostics: the side aims of this thesis deal with cryo-EM structural analysis of two different Ferritins chimeras whose constructs have been designed and optimized by our group
L'errore di diritto nella penalistica italiana tra Otto- e Novecento, in D. Fondaroli - G Fornasari - V. Militello (a cura di), Scritti penalistici italiani per Manfred Maiwald, Torino, 2025, 55-66
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Principi di diritto penale: parte generale. Nona edizione riveduta e aggiornata
No full textNona edizione della Parte generale dei Principi di diritto penale, di Antonio Pagliaro, riveduta e aggiornata da Vincenzo Militello, Manfredi Parodi Giusino e Alessandro SpenaNinth edition of Antonio Pagliaro' Principles of criminal law, General part, revised and updated by Vincenzo Militello, Manfredi Parodi Giusino e Alessandro Spen
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Crime mapping e controllo del territorio. Dai professionisti della protezione ai dilettanti della predazione
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