1,721,013 research outputs found
About “Jayaratne YS, Deutsch CK, Zwahlen RA. A 3-dimensional anthropometric analysis of the orolabial region in Chinese young adults” [Br J Oral Maxillofac Surg 2013;51:908–12]
No full textNovel enantioselective esterases from yeasts and bacteria
No full textThe major goal of our research is the developement of synthetically useful selective biotransformations using “new” microbial enzymes by combining natural and non-natural conditions. Enantioselective hydrolysis of chiral or prochiral esters can be used in different fields (i.e. pharma, agrofood, materials) for obtaining optically pure alcohols or carboxylic acids.
While a number of lipases is commercially available as free or immobilized enzymes, esterases are much less studied, although they show interesting features, such as:
• Esterases show chemo-, regio- and stereoselectivity alternative or complementary to the ones displayed by lipases.
• Esterases are much less used for the synthesis of optically pure products and their commercial availability is limited.
We have built-up a library of 75 microorganisms belonging to different genera having cell-associated esterases selected after screenings carried out on chiral esters of primary alcohols which are hydrolysed with low enantioselectivity by commercial lipases.
New cell-bound carboxylesterases from bacteria (i.e. Bacillus coagulans, Streptomyces sp.) and yeasts (i.e. Kluyveromyces marxianus, Pichia sp.) have been studied and partially characterised. They have been employed for different enantioselective hydrolysis of chiral esters (i.e. solketal and aminoacid esters), not easily and/or efficiently resolved with commercial enzymes. Different strategies of optimisation and developement of processes yelding multi-gram scale production will be also discussed
Dov'è il paesaggio veneto? Alcune riflessioni tra percezione degli abitanti e prospettive di governo del territorio, alla luce della Convenzione Europea del Paesaggio
No full textL'articolo propone una lettura del rapporto tra popolazione e territorio nel Veneto alla luce degli spunti proposti dalla Convenzione Europea del Paesaggi
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Landscapes
No full textThe landscapes section explores the subject from a territorial standpoint: the focus is not on the singularity of the assets, but on the system of relationships that holds together a number of resources spread over a large area of the territory. Grasping the connections that underlie the perceptible manifestations of the terrestria environment is certainly a necessary step in recognizing heritage within the scope of the territory. By discovering this system of relationships, one understands the sense of the past and the sense of the place that endow the heritage with an identity, making it available, among other things, for tourism, a conscious act of
appreciation and use of places
Rural Identity. Landscape, haritage, tourism in the mid-Adriatic areas
No full textLocation and ground anchoring are the characteristics which immediately refer to architecture, inventive activity which, more than any other, firmly settles constructions to precise places: without the possibility of being transferable, the recognition of intrinsic qualities is closely linked to the specificity of the context in which it is situated. Architectural heritage and territory are therefore tied together in a biunivocal relationship which extends beyond time and narrates the very sense of places, creating identity
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Enantioselective production of 3-hydroxy metabolites of tibolone by yeast reduction
No full textThe enantioselective reduction of tibolone into the corresponding 3α-hydroxy or 3β-hydroxy metabolite can be controlled by choosing suited strains of yeasts and biotransformation conditions. A restricted screening performed among 52 yeasts showed that the 3α-epimer was preferentially obtained with high epimeric purity with various strains (i.e. with Kluyveromyces lactis CBS 2359), while only Saccharomyces cerevisiae CBS 3093 gave the 3β-epimer as major product. The reduction of tibolone with K. lactis CBS 2359 and S. cerevisiae CBS 3093 was optimised. S. cerevisiae CBS 3093 furnished a 96:4 ratio of 3β/3α with complete molar conversion within 72 h when the initial concentration of substrate was below 2.5 g/L. K. lactis CBS 2359 gave a 99:1 ratio of 3α/3β with complete conversion in 64 h
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