7,331 research outputs found
Botta v. Brunner - A Restraint upon Advocacy
No full textNo single decision in recent years has had wider repercussions nor greater impact upon trial advocacy than the decision in Botta v. Brunner. It is probable that within the next few years every state jurisdiction will review the philosophy of the Botta case, and come to a conclusion that will control the method of final argument, in each state, on all the intangible elements of damages
In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design
No full textMaurizio Botta was born in Manziana, near Rome (Italy), on May 1950. He built his background in chemistry at Sapienza University of Rome, and then, he received his Ph.D. in 1979 at the University of Brunswick (Canada) working at the total synthesis of complex natural products under the supervision of Prof. Karel Wiesner. From 1980 to 1987, he was a Researcher at the Sapienza University of Roma, and thanks to a NATO grant, he spent one year in 1985–1986 working as a postdoctoral associate in the group of Prof. Stephen Hanessian at the University of Montreal (Canada), where he was also invited as a visiting scientist many other times thereafter.(1) In 1987, he became an Associate Professor of medicinal chemistry at the University of Siena (Italy) and then a Full Professor in 2000. His scientific career was objectively successful, as he was author in more than 400 papers and books or book chapters, as well as inventor in more than 25 patents. He was a member of many scientific societies and editorial boards of journals mostly devoted to chemistry, medicinal chemistry and drug design. Particularly, he served as an Associate Editor for ACS Medicinal Chemistry Letters.
Besides his chemical background, in his research life Maurizio was intrigued by multiple fields adjacent to synthetic chemistry, such as biochemistry, biophysics, molecular biology, and computational modeling. This latter captured his attention and was implemented in his research activity as a crucial support to drug design since the beginning of the 1990s. It is worth noting that most of Botta’s publications report on the use of computational tools, mostly relying on (but not limited to) molecular mechanics (MM) approaches to rationalize existing biological data, or to drive the design and synthesis of bioactive compounds. His research initially focused on conformational analysis of small molecules with the double aim to seize the enormous possibilities offered by MM in modeling conformational flexibility detected by NMR spectroscopy, as well as to exploit the active analogue approach (AAA) developed by Prof. Garland Marshall to interpreting pharmacological properties of bioactive compounds.(2) Thanks to the fruitful collaboration with Prof. Kosta Steliou (University of Montreal), near the beginning of the 1990s, his group started to use the VAX version of Model software, implemented with the MMX force field that was especially suitable to modeling molecular systems with π-electron delocalization. In the same years, MacroModel was used to model with high accuracy the flexibility of an increased number of organic molecules thanks to different force fields, while the use of Sybyl was initially related to its graphic potential but would later pave the way to using the CoMFA 3D-QSAR methodology. Since then, the role of computational modeling studies became more and more relevant in the research of Maurizio’s group, up to the publication of papers mostly or exclusively conducted at the theoretical level. The crucial role of theoretical approaches in drug design was highlighted by the successful series of workshops, i.e., the European Workshop in Drug Design (EWDD), held every two years in the lovely location of Certosa di Pontignano in the countryside of Siena (Italy).
The aim of this paper is to honor the memory of Prof. Maurizio Botta and to briefly overview the major contributions he gave to the field of computer-aided drug design, chemical information, and modeling. Works that represented a milestone in his research strategy are briefly overviewed herein, grouped on the basis of the topic. Finally, a note to the EWDD series is provided
La questione monetaria e la Conferenza di Parigi / Vittorio Ellena Roma : Botta, 1884
No full textLa questione monetaria e la Conferenza di Parigi / Vittorio Ellena
Roma : Botta, 1884
39 p. ; 24 cm
Estr. da: Nuova antologia, v. 47., s. 2., fasc. 20, 15 ottobre 1884
Nuevas bibliográficas de la "Tragicomedia de Calisto y Melibea" (Zaragoza, Jorge Coci, 1507)
No full textDoubly adaptive zero-knowledge proofs
No full textIn [TCC 2009 and JoC 2011] Lindell and Zarosim defined adaptive-corruption zero knowledge giving to the environment the power to perform post-execution corruption only. Moreover, their zero-knowledge proof system does not enjoy adaptive-input selection since it crucially relies on fixing the inputs already at the onset of the protocol. In this paper, we propose a new definition of adaptive-corruption zero-knowledge proofs that more naturally fits the setting that benefits from adaptive-input selection. We allow the non-rewindable environment to corrupt the prover adaptively based on its visibility of the messages exchanged so far. Then we show a zero-knowledge proof system for NP that is doubly adaptive (i.e., it enjoys adaptive-corruption under our stronger notion and adaptive-input selection) matching the same assumptions and round complexity of classical zero-knowledge proofs
IL MESTIERE DI ARCHITETTO: IL PROGETTO NEL RAPPORTO CON LE CONDIZIONI DELLA PRODUZIONE : MARIO BOTTA, VITTORIO GREGOTTI E RENZO PIANO
No full textIl Libro e gli incontri pubblici di presentazione con Vittorio Gregotti, Mario Botta e Renzo Piano hanno come scopo quello di indagare i limiti e le problematiche del mestiere di Architetto collegate con i meccanismi della produzione e della committenza. Attraverso le esperienze progettuali e di cantiere dei tre progetti pubblicati in volume si analizzano le mediazioni necessarie tra memoria storica e know--how, tra professionista e cliente, tra idea progettuale e controllo sulla realizzazione dell'opera
Towards Data Redaction in Bitcoin
No full textA major issue for many applications of blockchain technology is the tension between immutability and compliance to regulations. For instance, the GDPR in the EU requires to guarantee, under some circumstances, the right to be forgotten. This could imply that at some point one might be forced to delete some data from a locally stored blockchain, therefore irreparably hurting the security and transparency of such decentralized platforms. Motivated by such data protection and consistency issues, in this work we design and implement a mechanism for securely deleting data from Bitcoin blockchain. We use zero-knowledge proofs to allow any node to delete some data from Bitcoin transactions, still preserving the public verifiability of the correctness of the spent and spendable coins. Moreover, we specifically use STARK proofs to exploit the transparency that they provide. Our solution, unlike previous approaches, avoids the complications of asking nodes to reach consensus on the content to delete. In particular, our design allows every node to delete some specific data without coordinating this decision with others. In our implementation, data removal can be performed (resp., verified) in minutes (resp., seconds) on a standard laptop rather than in days as required in previous designs based on consensus
Assessment of the Main Criticalities in the Automotive Battery Supply Chain: A Professionals’ Perspective
No full textThe environmental transition has become a crucial element in the European Commission agenda. In this context, a key role is play by the electrification of the mobility that is viewed as a feasible alternative respect to the traditional fossil fuel paradigm, due to significant energy benefits. However, the scarcity availability of raw materials for producing battery packs and their concentration in few specific areas of the world, is determining high level of uncertainties and vulnerability in the supply chains of European car manufacturers. In particular, they are heavily facing the challenges that this transition is posing, specifically considering the reorganization and the structure of the associated supply chain. Therefore, this paper aims at capturing the perspectives of automotive industry about the different stages of the battery supply chain in the electric vehicle market. To this end, a questionnaire survey has been administrated to a set of identified automotive professionals. The obtained results underline that procurement, production and recycling of batteries are the most critical steps. On the contrary, the transport and the storage of the batteries are seen less crucial. This research is intended to stimulate future studies on innovative supply chains able to better manage batteries, and it is aimed at supporting car producers on designing more accurately their supply chain and to support decision makers in more effectively develop policy in the field of the electric mobility transition
Mario Botta e la nuova chiesa parrocchiale di Sambuceto
No full textIl 3 febbraio 2007 Mario Botta ha presentato a Pescara, nella Facoltà di Architettura dell'Università "d'Annunzio", il progetto di fattibilità per la nuova chiesa parrocchiale di S. Rocco a Sambuceto. Il tema progettuale relativo agli edifici sacri ha occupato gran parte dell'ultima produzione di Mario Botta, che, come ribadito a Pescara, è arrivato al Sacro progettando chiese ma anche una sinagoga ed un moschea, trovando le ragioni più profonde dell’architettura tout court. In quell’occasione l’autore ha incontrato il maestro ticinese trattando alcuni grandi temi della sua carriera e dell’architettura internazionale non solo contemporanea. La pubblicazione ripercorre le tappe più salienti del rapporto tra Botta e la progettazione di nuove chiese, per stringere la focale sull’episodio di Sambuceto, che ha interessato anche un difficile confronto con la precedente chiesa progettata e realizzata da Paride Pozzi, uno dei protagonisti dell’architettura del Novecento abruzzese. Chiude il volume l’intervista vera e propria, condotta dall’autore e consistente su cinque domande tematiche concernenti il rapporto tra l’architetto e la religione, l’eredità nel territorio dei grani lombardi dei secoli scorsi, la tipologia dello spazio sacro e le possibilità, oggi, della didattica di architettura.
On February 3, 2007 Mario Botta presented the feasibility study for the new parish church of St. Rocco, Sambuceto in the Faculty of Architecture at the University of "D'Annunzio", Pescara. The design theme related to the sacred buildings has occupied much of Mario Botta’s latest production whom, as reconfirmed in Pescara, arrived at Sacred buildings designing churches, but also a synagogue and a mosque, rapidly finding the underlying philosophy of architecture. On that occasion the author met the maestro Ticino and dealt with some of greatest subjects of his career, not only contemporary international architecture. The publication traces the phases of the relationship between Botta and the design of new churches, to increase the focus on Sambuceto which involved a difficult comparison between the previous church designed and built by Paride Pozzi, one of the key protagonists of twentieth century architecture in Abruzzo. The book ends with the interview itself, conducted by the author consisting of five questions and issues concerning the relationship between the architect and religion, the legacy of the region of Lombard grain in past centuries, types of sacred space and the opportunities today, in architectural teaching
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